Abstract：
BACKGROUND:Recent reports indicated that the slope of the foveal depression influences the macular pigment (MP) spatial profile. MP has been shown to confer possible protection against age-related macular degeneration (ARMD) because of its antioxidant properties. AIMS:To study the configuration of foveal slope and the foveal thickness in fellow eyes of subjects with unilateral neovascular ARMD. SETTINGS AND DESIGN:Case-control series. MATERIALS AND METHODS:The study population consisted of 30 cases aged >50, who had unilateral choroidal neovascular membrane (CNVM) or disciform scar in the fellow eye and 29 controls aged >50, who had no sign of ARMD in the either eye. Using spectral-domain optical coherence tomography, foveal thickness at different locations including the central subfield foveal thickness (CSFT) was noted. The foveal slopes were calculated in the six radial scans (between 0.25° and 1° retinal eccentricity) as well as the 3D scan. RESULTS:Cases had a significantly higher CSFT when compared to controls (215.1 ± 36.19 μ vs. 193.0 ± 17.38 μ, P = 0.004). On the 3D scan, the cases had shallower superior (cases 1.32 ± 0.32 vs. controls 1.45 ± 0.13, P = 0.04) and temporal slopes (cases 1.27 ± 0.21 vs. controls 1.39 ± 0.12, P = 0.01) in comparison to the controls. CONCLUSIONS:We noted a shallower superior and temporal foveal slope and a higher CSFT in the fellow eyes of subjects with a unilateral neovascular ARMD. Prospective studies observing the development of CNVM in subjects with altered foveal slope might provide more information on this optical coherence tomography finding.
journal_name
Indian J Ophthalmoljournal_title
Indian journal of ophthalmologyauthors
Raman R,Lahane S,Gupta A,Sandeep D,Sharma Tdoi
10.4103/0301-4738.119437subject
Has Abstractpub_date
2013-09-01 00:00:00pages
507-10issue
9eissn
0301-4738issn
1998-3689pii
IndianJOphthalmol_2013_61_9_507_119437journal_volume
61pub_type
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