Abstract：
PURPOSE:To determine the association of demographics, leprosy and ocular characteristics with altered levels of lactoferrin in the tears of normal subjects and leprosy patients, and to detect the presence of antibodies to lactoferrin in these tear samples. METHOD:We collected light-stimulated tears from 298 leprosy patients and an equal number of normal subjects using the glass capillary method. Free lactoferrin levels were estimated using ELISA and the presence of antibodies to lactoferrin was detected using the immuno-blotting method. Significant associations were looked for between tear lactoferrin levels and demographic characteristics, leprosy characteristics such as type of disease, duration of disease, reactions, deformity and bacterial load, and ocular complications, using chi-square and regression analysis. RESULTS:Tear lactoferrin levels with a mean (SD) of 2.55 (2.83)mg/ml in the control group were significantly different (P<0.000) from leprosy patients with a smean (SD) of 5.66 (7.21)mg/ml. Age showed an inverse correlation with tear lactoferrin levels in controls. Increased bacterial load, grade 2 leg deformity and Type 2 reactions were significantly associated (P<0.05) with increased tear lactoferrin levels. Type 2 reactions remained significantly associated (P=0.01) on multiple regression analysis. Tear lactoferrin levels were not associated with gender, serum lactoferrin levels, Type 1 reactions, face patches, treatment status, orbicularis oculi weakness, lagophthalmos, ectropion, entropion, corneal opacity, cataract and iridocyclitis. CONCLUSION:Age is inversely related to tear lactoferrin levels in normal subjects. Free lactoferrin levels in tears are significantly higher in leprosy patients compared with normal controls. Type 2 reactions in leprosy are significantly associated with elevated tear lactoferrin levels.
journal_name
Indian J Ophthalmoljournal_title
Indian journal of ophthalmologyauthors
Daniel E,Duriasamy M,Ebenezer GJ,Shobhana,Job CKkeywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
51-6issue
1eissn
0301-4738issn
1998-3689journal_volume
52pub_type
杂志文章abstract：:A 63-year-old female patient complained of dimness in the central field of vision in the left eye after viewing an annular partial eclipse without adequate eye protection on 22 July 2009. Fundoscopy showed a wrinkled macular surface. Fundus autofluorescence study revealed well-demarcated hyperautofluorescence at the f...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.103799
更新日期：2012-11-01 00:00:00
abstract：: ...
journal_title：Indian journal of ophthalmology
pub_type： 评论,信件
doi：10.4103/ijo.IJO_1124_18
更新日期：2019-01-01 00:00:00
abstract：:Traumatic subconjunctival dislocation of the posterior chamber intraocular lens (PCIOL) is a rare and emergency condition. Here, we report an interesting variation of rare case of inferior subconjuctival dislocation of PCIOL in a 75-year-old female patient following blunt trauma to her right eye with cow's head. All t...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_359_16
更新日期：2017-06-01 00:00:00
abstract：:For the purpose of this symposium, the term "keratitis" implies suppurative nonviral and viral keratitis. Corneal ulcers have been described in ancient literature. But even today, despite the availability of a wide range of newer antimicrobials and new diagnostic techniques, infective keratitis continues to pose a dia...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.40358
更新日期：2008-05-01 00:00:00
abstract：Purpose:To analyze the outcome of cataract surgery in patients with ocular tuberculosis (OTB). Methods:Medical records of patients with OTB who underwent cataract surgery between 2005 and 2018 were retrospectively reviewed. The primary outcome measure was corrected distant visual acuity (CDVA), and a good outcome was ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_428_20
更新日期：2020-09-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_736_18
更新日期：2019-01-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.121133
更新日期：2013-12-01 00:00:00
abstract：:Keratoconus is a progressive corneal thinning disease associated with significant tissue remodeling activities and activation of a variety of signaling networks. However, it is not understood how differential gene and protein expression direct function in keratoconus corneas to drive the underlying pathology, ectasia....
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/0301-4738.116056
更新日期：2013-08-01 00:00:00
abstract：:To compare the astigmatism induced by a superior, supero-temporal and temporal incision in manual small incision cataract surgery. Induced astigmatism was analysed by Cartesian coordinates based analysis, using Holladay's system. Mean astigmatism induced by surgery was 1.28 Dx2.9 degrees for superior incision, 0.20 Dx...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.16684
更新日期：2005-09-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.170984
更新日期：2015-09-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：:We report successful surgical management of a circumscribed choroidal hemangioma with exudative retinal detachment refractory to transpupillary thermotherapy (TTT). A 33-year-old man with symptomatic serous macular detachment in the left eye (Snellen acuity: 20/200) secondary to a paramacular choroidal hemangioma was ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.33044
更新日期：2007-07-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.116481
更新日期：2014-02-01 00:00:00
abstract：: ...
journal_title：Indian journal of ophthalmology
pub_type： 社论
doi：10.4103/ijo.IJO_1894_18
更新日期：2018-12-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.4103/ijo.IJO_585_16
更新日期：2017-12-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/ijo.IJO_910_17
更新日期：2018-07-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/ijo.IJO_648_17
更新日期：2017-09-01 00:00:00
abstract：:A 60-year-old female came to our hospital with defective vision due to persistent diabetic macular edema and was treated with intravitreal ozurdex implant in the right eye. Three days later, the patient presented with diminution of vision, ocular pain, congestion, and hypopyon with no fundus view. B-scan ultrasonograp...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_810_16
更新日期：2017-07-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.178143
更新日期：2016-01-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.132107
更新日期：2014-04-01 00:00:00
abstract：Purpose:To evaluate the effect of COVID-19 pandemic and national lockdown on patient care at a tertiary-care ophthalmology institute. Methods:Records of all the patients who presented from March 25th to May 3rd, 2020 were scanned to evaluate the details regarding the presenting complaints, diagnosis, advised treatment...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_1673_20
更新日期：2020-08-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.149137
更新日期：2014-12-01 00:00:00
abstract：:Prepapillary arterial loops are congenital vascular anomalies that have been noted to cause arterial occlusions. We report a case of superior branch macular artery occlusion in an eye with two independent prepapillary arterial loops, following a Valsalva-like mechanism. ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.16178
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:The thesis is an integral part of postgraduate medical education in India. Publication of the results of the thesis in an indexed journal is desirable; it validates the research and makes results available to researchers worldwide. AIMS:To determine publication rates in indexed journals, of works derived fr...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.60070
更新日期：2010-03-01 00:00:00
abstract：:Ocular bee stings are known to cause corneal melts, corneal infiltrates, cataracts, and secondary glaucoma. Our patient presented with scleritis, corneal infiltrates, and endophthalmitis after a ocular bee sting. Topical treatment led to resolution of anterior segment inflammation, but the scleritis and vitreous infla...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_889_17
更新日期：2018-03-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type：
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更新日期：2020-09-01 00:00:00
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journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.82003
更新日期：2011-07-01 00:00:00
