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Proteomic and gene expression patterns of keratoconus.

Abstract：

:Keratoconus is a progressive corneal thinning disease associated with significant tissue remodeling activities and activation of a variety of signaling networks. However, it is not understood how differential gene and protein expression direct function in keratoconus corneas to drive the underlying pathology, ectasia. Research in the field has focused on discovering differentially expressed genes and proteins and quantifying their levels and activities in keratoconus patient samples. In this study, both microarray analysis of total ribonucleic acid (RNA) and whole proteome analyses are carried out using corneal epithelium and tears from keratoconus patients and compared to healthy controls. A number of structural proteins, signaling molecules, cytokines, proteases, and enzymes have been found to be deregulated in keratoconus corneas. Together, the data provide clues to the complex process of corneal degradation which suggest novel ways to clinically diagnose and manage the disease. This review will focus on discussing these recent advances in the knowledge of keratoconus biology from a gene expression and function point-of-view.

journal_name

Indian J Ophthalmol

journal_title

Indian journal of ophthalmology

authors

Ghosh A,Zhou L,Ghosh A,Shetty R,Beuerman R

doi

10.4103/0301-4738.116056

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

389-91

issue

8

eissn

0301-4738

issn

1998-3689

pii

IndianJOphthalmol_2013_61_8_389_116056

journal_volume

61

pub_type

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