Abstract:
BACKGROUND:Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease. METHODS:TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17). RESULTS:Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01). CONCLUSION:The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.
journal_name
Indian J Ophthalmoljournal_title
Indian journal of ophthalmologyauthors
Srivastava P,Saxena S,Khanna VK,Kumar D,Nath R,Seth PKkeywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
307-9issue
4eissn
0301-4738issn
1998-3689journal_volume
48pub_type
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journal_title:Indian journal of ophthalmology
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journal_title:Indian journal of ophthalmology
pub_type: 杂志文章,评审
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pub_type: 评论,信件
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journal_title:Indian journal of ophthalmology
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