Calciphylaxis: a rare complication in alcoholic liver disease.

Abstract:

:Calciphylaxis, or calcific uremic arteriolopathy (CUA) is a rare but well described entity in patients with endstage renal disease (ESRD) and/or hyperparathyroidism. CUA is characterized by systemic acute calcification of the small and intermediate dermal vasculature that can lead to epidermal ischemia, ulceration, and necrosis. Cutaneous lesions of calciphylaxis characteristically begin as tender, violaceous, livedoid discolorations. The mechanisms of disease remain poorly understood although abnormal bone and mineral metabolism and hyperparathyroidism can contribute to CUA. Therapeutic strategies are of unproven benefit and mortality remains high. Calciphylaxis has also been extremely rarely reported in patients without ESRD and/or hyperparathyroidism. We report an unusual case of calciphylaxis in a patient with alcoholic liver cirrhosis and normal renal function, without any alteration in the phosphocalcic and parathyroid hormone (PTH) metabolisms.

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

Sermijn E,Strobbe T,Vandekerckhove L,Libbrecht L,Colle I,Schoonjans R,Vogelaers D

doi

10.2143/ACB.2863

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

116-9

issue

2

eissn

1784-3286

issn

2295-3337

journal_volume

68

pub_type

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