Even if it looks like COVID-19, think again: the importance of differential diagnosis during a pandemic.

Abstract:

:Introduction:Antisynthetase syndrome (ASSD) is a rare auto-immune condition that can present as interstitial lung disease (ILD) and progress into Acute Respiratory Distress Syndrome (ARDS). Importance:The purpose of this clinical case is to highlight the importance of considering less prevalent causes of ARDS amid the COVID-19 pandemic. Case report:We present a 56-year-old Belgian female of African descent without past medical history who demonstrated typical signs of COVID-19 at the start of the pandemic. Based on the disease course as well as CT-scan findings, a diagnosis of COVID-19 was made. She progressed to ARDS for which she got intubated and was started on venovenous membrane oxygenation (VV-ECMO). Despite initial negative screening for antinuclear antibodies, further analysis revealed anti-Jo-antibodies. Diagnosis of ASSD was eventually retained and immunosuppressive therapy was started. However, pulmonary fibrosis had evolved too far and therapy was halted shortly after.

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

Van Cauwelaert S,Stylemans D,D'Haenens A,Slabbynck H,Nieuwendijk R

doi

10.1080/17843286.2021.1872312

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

1-5

eissn

1784-3286

issn

2295-3337

pub_type

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