Abstract:
:We present a patient with therapy resistant multicentric reticulohistiocytosis (MRH). MRH is a rare granulomatous, multisystem disease characterised most frequently by disfiguring papulonodular skin lesions and sometimes a destructive polyarthritis, though any organ can be involved. Abnormal histiocytic reactions to an undetermined stimulus (possibly an associated mycobacterial infection, auto immune process or neoplastic process) have been proposed as an underlying mechanism. The diagnosis is confirmed by histopathology of the cutaneous nodules and/or synovial membrane by the presence of CD68-positive histiocytes and multinucleated giant cells with an eosinophilic 'ground-glass' cytoplasm. Recent studies have identified TNFalpha and other inflammatory cytokines to be highly expressed in the synovium and synovial fluid of affected joints in patients with MRH. Based on these findings, we treated our patient with infliximab in combination with methotrexate with marked improvement of morning stiffness, tender and swollen joint count, visual analogue scale and health assessment questionnaire after his third infusion. However, the nodules did not markedly resolve. When treating patients with MRH with TNFa neutralizing drugs, one has to keep the possible association with malignancy in 15-30% of cases in mind and these products should be used with caution.
journal_name
Acta Clin Belgjournal_title
Acta clinica Belgicaauthors
De Knop KJ,Aerts NE,Ebo DG,Van Offel JF,Stevens WJ,De Clerck LSdoi
10.2143/ACB.66.1.2062520subject
Has Abstractpub_date
2011-01-01 00:00:00pages
66-9issue
1eissn
1784-3286issn
2295-3337journal_volume
66pub_type
杂志文章abstract::Insertion sequences IS481 and IS1001 are targets for molecular detection of respectively Bordetella pertussis and Bordetella parapertussis. There is a raising concern about specificity of these targets due to sequence similarity with Bordetella holmesii and Bordetella bronchiseptica. The likelihood of false (para)pert...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.2143/ACB.3341
更新日期:2013-09-01 00:00:00
abstract::The patient in this report was diagnosed simultaneously with primary biliary cirrhosis (PBC), spondyloarthritis, and generalized morphea and was started on infliximab therapy. In addition to an improvement in clinical symptoms with this therapy, an improvement was also observed in laboratory parameters such as cholest...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2017.1290567
更新日期:2017-10-01 00:00:00
abstract::After notification of a case of fulminant hepatitis B virus (HBV) infection in a 83-year-old female resident of a nursing home to the Flemish Health Inspectorate, a seroepidemiological study and a retrospective cohort study were conducted among the 94 residents and 47 nursing staff to assess the extent of HBV transmis...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2005.012
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:pp65 antigenaemia and real-time PCR are two methods that are used to diagnose CMV infection in its early stages and, thereby, to facilitate initiation of pre-emptive therapy. OBJECTIVES:Firstly, to compare PCR with antigenaemia and clinical outcome in order to define a clinical threshold for starting pre-em...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2009.083
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:Recently, SOHO and CATIE's studies in the field of schizophrenic disorders asserted that molecules apparently showing the most side-effects are not only the most effective but also lead to the least changes in treatments. Can we generalise this assertion to other domains of pharmacological treatments, such a...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2008.043
更新日期:2008-07-01 00:00:00
abstract::Almost all epidemiologic studies have shown that the age-adjusted incidence of osteoporotic hip fracture has been increasing during the last decades. Although the age-related bone loss is considered to be a crucial determinant of the incidence of hip fracture, spontaneous fractures appear to be uncommon: about 90% of ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1993.11718306
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:We previously validated uHear™ to screen for hearing loss in older patients with cancer without a known hearing loss, as part of a comprehensive geriatric assessment (CGA). In view of low specificity, we tested a new modified uHear™ scoring system as described by Handzel. METHODS:Patients, aged ≥70 years, we...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2017.1392070
更新日期:2018-04-01 00:00:00
abstract::Elevated intra-abdominal pressure (IAP) exerts effects not only on intra-abdominal organs, but also on organs distant to the abdominal compartment. Abdomino-thoracic interaction during intra-abdominal hypertension (IAH) or abdominal compartment syndrome (ACS) interferes with pulmonary, cardiovascular and cerebral func...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::Within the scope of an information campaign of the Belgian Institute for Road Safety an attempt was made to classify 179 medicinal drugs from 9 therapeutic groups, listed in the Belgian "Commented Repertory of Drugs--1997", according to their effect on driving performance. The categorisation was based on literature da...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Tramadol is a weak opioid with effects on adrenergic and serotonergic neurotransmission that is used to treat cancer pain and chronic non malignant pain. This drug was initiated in association with paroxetine and dosulepine hydrochloride in a tetraparetic patient with chronic pain. Fifty-six days after initiation of t...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1996.11718509
更新日期:1996-01-01 00:00:00
abstract::We retrospectively studied 29 cases of S.pyogenes bacteremia, treated from September 1985 through September 1993, in order to define the clinical pattern, predisposing factors and the outcome of S.pyogenes bacteremia in our region. The number of infections, the clinical picture and mortality rate of S.pyogenes bactere...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1995.11718427
更新日期:1995-01-01 00:00:00
abstract::Exhaustion of antigen-specific T-cells in order to escape immune destruction is frequently seen in chronic viral infection and different types of cancer. Blockade of overexpressed negative co-stimulatory pathways, a process known as immune checkpoint modulation, is a promising novel therapy that could improve the trea...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2020.1741897
更新日期:2020-03-17 00:00:00
abstract::Up to a little while ago there was no uniform definition for acute kidney injury (AKI). Recently, the Acute Dialysis Quality Initiative proposed the RIFLE consensus classification for AKI. This classification was adapted and modified by the Acute Kidney Injury Network into the AKI staging system. This classification d...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2007.071
更新日期:2007-01-01 00:00:00
abstract::In Belgium, individual laboratory and treatment data of all HIV-infected patients seen in the 9 AIDS Reference Centres and 7 AIDS Reference Laboratories are collected prospectively since 2006. We present here an analysis of patients recorded in the cohort database between 1st of January 2006 and 31st of December 2008....
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.2143/ACB.67.5.2062686
更新日期:2012-09-01 00:00:00
abstract:AIM:To investigate the correlation between liver echogenicity and serum C-peptide levels in type 2 diabetic patients treated with oral hypoglycaemic agents. PATIENTS AND METHODS:The study included 231 type 2 diabetic patients (114 men) with a mean age of 64.3 +/- 6.9 years and a mean diabetes duration of 8.5 +/- 3.2 y...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2006.002
更新日期:2006-01-01 00:00:00
abstract::We present the case of a 51-year-old woman who presented a right supraclavicular mass corresponding to lymphadenitis with atypical mycobacterium (Mycobacterium genavense). Later, she developed subcutaneous purulent small nodules containing the same germ. The presence of this mycobacterium was in the context of recurre...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/0001551213Z.00000000016
更新日期:2014-04-01 00:00:00
abstract::Background Trichinellosis is a parasitic infection caused by nematodes of the genus Trichinella, and its principal mode of transmission is the consumption of raw or undercooked contaminated meat. Cardiac involvement in trichinellosis is unusual, yet it represents the most frequent cause of death. Here, we report a cas...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2020.1790867
更新日期:2020-07-04 00:00:00
abstract::Erysipelothrix rhusiopathiae is a rare cause of endocarditis. Most cases were observed in people working with animals. We report a case in a 45-year old man without any exposure to animals. He was admitted to our hospital because of dyspnoea. Blood cultures were drawn following fever on day 8 of hospitalisation. Erysi...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2003.58.6.006
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:Intra-abdominal pressure (IAP) has traditionally been measured in the supine position, however, measuring the pressure in lateral semi-recumbent position has not been studied. DESIGN:A single centre prospective 1-day study. PATIENTS:10 patients admitted for more then 24 hours who were mechanically ventilate...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2009.037
更新日期:2009-05-01 00:00:00
abstract::Pregnancy is a cardiovascular and metabolic challenge to the human female body. This review summarizes current knowledge on the regulation of blood pressure and plasma volume in normal and hypertensive pregnant women. During pregnancy, systemic vascular resistance and blood pressure decrease, whereas cardiac output an...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2010.050
更新日期:2010-07-01 00:00:00
abstract::The National Institute for Insurance of Disease and Disablement (RIZIV/INAMI) in Belgium reimburses the costs of long term oxygen therapy (LTOT) by concentrators since 1984 and by liquid oxygen since 1988 for specific categories of patients supervised by approved medical centers. Since then we prescribed these therapi...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1995.11718439
更新日期:1995-01-01 00:00:00
abstract::The kidney could be the cause of essential hypertension which can also cause renal disease. High blood pressure is also very common in chronic kidney disease, and is moreover a well-known risk factor for a faster progression of kidney failure. Hypertension and kidneys are thus closely linked. Hypertension must be aggr...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2007.002
更新日期:2007-01-01 00:00:00
abstract::We report the case of a 32-year-old patient with Wegener's granulomatosis (WG) associated with a (biopsy - proven) renal inflammatory pseudotumour (IPT) of the left kidney treated by a partial nephrectomy, glucocorticoids and immunosuppressive drugs, in whom a relapse of renal IPT was found 6 years after the diagnosis...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2010.65.6.011
更新日期:2010-11-01 00:00:00
abstract::The present study compares two new factor VIII preparations currently used in the treatment of haemophilia. A Factor VIII was partially purified from plasma obtained from unpaid voluntary Belgian donors in the blood transfusion centers of Lille and Amsterdam and virus-inactivated by exposure to solvent-detergent (FVII...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1991.11718180
更新日期:1991-01-01 00:00:00
abstract::Infection with hepatitis B virus has become a vaccine-preventable disease. The recombinant hepatitis B vaccines available today are safe and immunogenic. In order for these vaccines to eradicate HBV a universal vaccination of neonates and/or children needs to be implemented. Major obstacles on the road to global hepat...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2001.032
更新日期:2001-07-01 00:00:00
abstract::Objectives: Water and electrolytes disturbances often occur in renal transplant recipients. The objective is to describe the pathophysiology and the treatment of the most prevalent abnormalities. Methods: We screened PubMed for the following words in various combination: kidney transplantation and (disturbances or abn...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2018.1549193
更新日期:2019-02-01 00:00:00
abstract::We present a case of cutaneous mucormycosis in a patient with several important risk factors precipitating disease, namely underlying acute myeloid leukaemia and poorly controlled secondary diabetes. Inoculation was most likely caused by repeated minor trauma (insulin injection) at the site of infection. Treatment con...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1080/17843286.2016.1266802
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Sarcoidosis is a multisystem inflammatory disorder of unknown etiology. It is characterized by the presence of noncaseating granulomas and an inflammatory process in which T lymphocytes, especially type-1 helper T (Th1) cells, macrophages and different cytokines are involved. Different studies ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2016.1152671
更新日期:2016-12-01 00:00:00
abstract::In comparing four currently available immunochemical methods for immunoglobulin quantification, i.e. radial immunodiffusion (RID), rate nephelometry (RN), laser nephelometry (LN) and turbidimetry (T), highly divergent results were obtained for monoclonal immunoglobulins. Comparison with data obtained by densitometric ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/22953337.1981.11718807
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:Although emergency department (ED) return visits are a significant problem universally, it has not been previously studied in our ED. The aim of this study was to determine the extent of the problem in our ED, to identify the relevant clinical predictor variables and to detect diagnostic errors. METHODS:A r...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2009.069
更新日期:2009-09-01 00:00:00