A national cohort of HIV-infected patients in Belgium: design and main characteristics.

Abstract:

:In Belgium, individual laboratory and treatment data of all HIV-infected patients seen in the 9 AIDS Reference Centres and 7 AIDS Reference Laboratories are collected prospectively since 2006. We present here an analysis of patients recorded in the cohort database between 1st of January 2006 and 31st of December 2008. During that period, 11982 patients were under medical follow-up in Belgium. Sixty-one percent of the patients were male and the median age was 39.8 at the time of first recorded viral load. Among the patients whose nationality or probable mode of transmission was recorded, nearly half (48.0%) were Belgian and 38.3% originated from Sub-Saharan Africa; heterosexual contacts were reported in the majority of cases (56.0%) followed by homosexual contacts (35.3%). A total of 145 deaths were reported. Around three quarters of the patients were on ART. The median CD4 cell count rose from 470 cells/mm3 in 2006 to 501 cells/mm3 in 2008. This cohort enabled us to obtain comprehensive information on the numbers and characteristics of HIV-infected patients currently being followed up in Belgium, and on trends in antiretroviral therapy and biological results. This will serve for planning purposes, evaluation of access to care and as a source of information for further studies.

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

Van Beckhoven D,Buvé A,Ruelle J,Seyler L,Sasse A,Belgian HIV Cohort Study Group.

doi

10.2143/ACB.67.5.2062686

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

333-7

issue

5

eissn

1784-3286

issn

2295-3337

journal_volume

67

pub_type

杂志文章
  • [Hypothalamic hypopituitarism with hyperphagia and subacute dementia due to neurosarcoidosis: case report and literature review].

    abstract::The frequency of neurologic involvement in sarcoidosis is about 5%. When the clinical picture presents with only neurological manifestations, as it did in our patient, the diagnosis at presentation is often difficult. Involvement of other tissues must therefore be actively searched. We describe a case of neurosarcoido...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1992.11718250

    authors: Vanhoof J,Wilms G,Bouillon R

    更新日期:1992-01-01 00:00:00

  • A microvascular myocardial infarction in a 16-year-old girl with antiphospholipid syndrome: a case report.

    abstract::Objective and importance: The antiphospholipid syndrome can manifest itself by silent (or not) myocardial infarction. Clinical presentation: We report the case of a 16-year-old girl who presented a myocardial infarction for whom a coronary-computer tomography did not reveal any coronary abnormalities or obstruction. S...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2018.1516182

    authors: Riga JP,Leone A,Lambot F,Cappeliez O,Friart A

    更新日期:2019-10-01 00:00:00

  • Disseminated Mycobacterium genavense infection in a patient with immunosuppressive therapy and lymphoproliferative malignancy.

    abstract::We present the case of a 51-year-old woman who presented a right supraclavicular mass corresponding to lymphadenitis with atypical mycobacterium (Mycobacterium genavense). Later, she developed subcutaneous purulent small nodules containing the same germ. The presence of this mycobacterium was in the context of recurre...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/0001551213Z.00000000016

    authors: Numbi N,Demeure F,Van Bleyenbergh P,De Visscher N

    更新日期:2014-04-01 00:00:00

  • Isolation of Prototheca zopfii from a finger. Case report and review of the literature.

    abstract::Prototheca zopfii, an alga-like organism, was isolated from subungual material in a patient with onycholysis. This organism seldom causes human infections. Clinical and laboratory aspects are described. The literature is reviewed. ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1991.11718171

    authors: Magerman K,Gordts B,Hindryckx P,Van Landuyt HW

    更新日期:1991-01-01 00:00:00

  • Prevalence of Bordetella holmesii and Bordetella bronchiseptica in respiratory tract samples from Belgian patients with pertussis-like symptoms by sensitive culture method and mass spectrometry.

    abstract::Insertion sequences IS481 and IS1001 are targets for molecular detection of respectively Bordetella pertussis and Bordetella parapertussis. There is a raising concern about specificity of these targets due to sequence similarity with Bordetella holmesii and Bordetella bronchiseptica. The likelihood of false (para)pert...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.3341

    authors: Van den Bossche D,De Bel A,De Smet D,Heylen O,Vekens E,Vandoorslaer K,Soetens O,Piérard D

    更新日期:2013-09-01 00:00:00

  • Analysis of foodborne disease in Belgium in 1997.

    abstract::Foodborne disease represents a major problem for public health in industrialized countries, albeit with a low lethality. Foodborne diseases are defined as a group of viral, bacterial or parasitic gastrointestinal infections transmitted by means of food. Proper food-hygiene practices and surveillance of individual dise...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2000.11754316

    authors: Van Loock F,Ducoffre G,Dumont JM,Libotte-Chasseur ML,Imberechts H,Gouffaux M,Houins-Roulet J,Lamsens G,De Schrijver K,Bin N,Moreau A,De Zutter L,Daube G

    更新日期:2000-11-01 00:00:00

  • Chain of rings: a radiographic sign of papillary thyroid cancer.

    abstract::Papillary thyroid cancer is the most common form of thyroid malignancy in children and adult with frequent metastases to the cervical lymph nodes. We present a case of metastatic papillary thyroid cancer with remarkable imaging findings of consecutive metastatic calcified lymph nodes resembling a chain of rings. While...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/2295333714Y.0000000084

    authors: Juan YH,Hsuan HF,Ng KK,Ng SH,Yu CW,Liu H,Lin YC

    更新日期:2015-04-01 00:00:00

  • Microvesicular steatosis of the liver.

    abstract::The term "microvesicular steatosis of the liver" refers to a variant form of hepatic fat accumulation whose histologic features contrast with the much more common macrovesicular steatosis. Microvesicular steatosis of the liver was originally described in association with conditions who share a number of biochemical an...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1990.11718105

    authors: Hautekeete ML,Degott C,Benhamou JP

    更新日期:1990-01-01 00:00:00

  • Epidemiology of type 1 and type 2 diabetes. The added value of diabetes registries for conducting clinical studies: the Belgian paradigm.

    abstract::Diabetes registries have documented that the lifetime risk of diabetes amounts to at least 10% in the western world. Moreover the prevalence of type 2 diabetes is increasing worldwide especially in developing countries. Furthermore there is a secular trend toward earlier clinical manifestation of both type 1 and type ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2004.001

    authors: Gorus FK,Weets I,Couck P,Pipeleers DG,Belgian Diabetes Registry.

    更新日期:2004-01-01 00:00:00

  • Hypothermia and Hodgkin's disease: case report and review of the literature.

    abstract::We reported the case of a patient with stage IV Hodgkin's disease (involving the nodes and Liver) presenting with paraneoplastic fever and who subsequently developed hypothermia during chemotherapy administration. We also reviewed the 12 other cases of hypothermia in Hodgkin's disease reported in the literature and di...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2006.042

    authors: Meert AP,Berghmans T,Sculier JP

    更新日期:2006-09-01 00:00:00

  • Management of refractory systemic rheumatic diseases.

    abstract::The management of refractory systemic rheumatic diseases remains a challenging issue. New immunosuppressive drugs have been developed which might improve long-term outcome, with a reasonably toxicity profile. Moreover, better understanding of the mechanisms underlying some of the systemic rheumatic disease has raised ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2003.58.5.009

    authors: Houssiau FA

    更新日期:2003-09-01 00:00:00

  • Definition of clinical threshold for CMV real-time PCR after comparison with PP65 antigenaemia and clinical data.

    abstract:BACKGROUND:pp65 antigenaemia and real-time PCR are two methods that are used to diagnose CMV infection in its early stages and, thereby, to facilitate initiation of pre-emptive therapy. OBJECTIVES:Firstly, to compare PCR with antigenaemia and clinical outcome in order to define a clinical threshold for starting pre-em...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2009.083

    authors: Mullier F,Kabamba-Mukadi B,Bodéus M,Goubau P

    更新日期:2009-11-01 00:00:00

  • Tuberculous mediastinal lymphadenopathy.

    abstract::We report about 2 cases of isolated mediastinal tuberculous lymphadenitis presenting without parenchymal infiltrates. Although rare, this mode of presentation reminds the clinician that tuberculosis has to be included in the differential diagnosis of mediastinal masses even in the absence of parenchymal lesion. Both c...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1998.11754153

    authors: Hainaut P,Monthe A,Lesage V,Weynand B

    更新日期:1998-04-01 00:00:00

  • Cardiovascular toxicity of cancer treatment.

    abstract::Drugs with potential cardiac toxicity are prominent in cancer treatment, not only the old chemotherapeutic agents, but also the newer targeted drugs and biologic agents. As the long-term survival of patients with malignancies has improved and cancer turned into a chronic disease, physicians must take into account the ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.66.4.2062566

    authors: Combes M,Rottey S,De Backer T

    更新日期:2011-07-01 00:00:00

  • Determinants of adherence in a cohort of Belgian HIV patients: a pilot study.

    abstract::Since the era of highly active antiretroviral therapy (HAART), HIV is considered a chronic disease. Adherence to HAART is crucial for effectiveness. Non-adherence negatively impacts patient outcome and the larger economy. However, data on adherence among the Belgian HIV cohort are scarce. Therefore, the purpose of thi...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/0001551214Z.00000000035

    authors: Degroote S,Vogelaers D,Vermeir P,Mariman A,De Rick A,Van Der Gucht B,Pelgrom J,Van Wanzeele F,Verhofstede C,Vancauwenberghe J,Vandijck D

    更新日期:2014-04-01 00:00:00

  • In vitro and in vivo evaluation of two factor VIII concentrates virally inactivated by solvent-detergent or by pasteurization.

    abstract::The present study compares two new factor VIII preparations currently used in the treatment of haemophilia. A Factor VIII was partially purified from plasma obtained from unpaid voluntary Belgian donors in the blood transfusion centers of Lille and Amsterdam and virus-inactivated by exposure to solvent-detergent (FVII...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1991.11718180

    authors: Peerlinck K,Arnout J,Tamise M,Vanherle A,Fondu P,Vermylen J

    更新日期:1991-01-01 00:00:00

  • Abdominal compartment syndrome and acute pancreatitis.

    abstract::Significant visceral edema associated with massive fluid resuscitation, paralytic ileus and formation of pancreatic ascites in patients with severe acute pancreatitis (SAP) can lead to abdominal compartment syndrome (ACS) that can contribute to the early development of multiple organ dysfunction syndrome (MODS), espec...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:

    authors: Leppäniemi A,Johansson K,De Waele JJ

    更新日期:2007-01-01 00:00:00

  • Relapsing infiltrates after pneumocystis pneumonia in stem cell transplant patients: think about BOOP!

    abstract::Bronchiolitis Obliterans Organizing Pneumonia (BOOP) can complicate allogeneic haematopoietic stem cell transplantation. It is associated with prior graft-versus-host disease (GVHD) and the case fatality is 21%. In 22%, diagnosis is preceded by tapering the corticosteroids given as a treatment for GVHD. We report a fa...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2010.042

    authors: Deeren D,Lammertijn L,Van Dorpe J

    更新日期:2010-05-01 00:00:00

  • Update on the management of acute severe pancreatitis.

    abstract::Acute severe pancreatitis is an aggressive disease with a mortality rate of up to 30 percent. In recent years therapy has shifted away from early surgery to intensive medical care. This article focuses on several issues of the management of acute severe pancreatitis emphasising evidence from recent clinical trials and...

    journal_title:Acta clinica Belgica

    pub_type: 社论,评审

    doi:10.1179/acb.2001.023

    authors: Ponette J,Wilmer A

    更新日期:2001-05-01 00:00:00

  • The use of hypnosedative drugs in a university hospital setting.

    abstract:OBJECTIVE:The use of hypnosedatives (HSs) in the hospital and at home before admission was registered. Also, the incidence of HSs newly started in the hospital and the incidence of withdrawal in chronic users while in hospital was recorded. METHODS:The study population consisted of 517 consecutively admitted patients ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2003.58.4.003

    authors: Warie H,Petrovic M,Somers A,Mariman A,Robays H,Pevernagie D

    更新日期:2003-07-01 00:00:00

  • Severity of liver echogenicity is correlated to serum c-peptide levels in type 2 diabetic patients.

    abstract:AIM:To investigate the correlation between liver echogenicity and serum C-peptide levels in type 2 diabetic patients treated with oral hypoglycaemic agents. PATIENTS AND METHODS:The study included 231 type 2 diabetic patients (114 men) with a mean age of 64.3 +/- 6.9 years and a mean diabetes duration of 8.5 +/- 3.2 y...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2006.002

    authors: Papanas N,Symeonidis G,Mavridis G,Papazoglou D,Giannakis I,Papatheodorou K,Pastore F,Lakasas G,Maltezos E

    更新日期:2006-01-01 00:00:00

  • Classification of medicines according to their influence on driving ability.

    abstract::Within the scope of an information campaign of the Belgian Institute for Road Safety an attempt was made to classify 179 medicinal drugs from 9 therapeutic groups, listed in the Belgian "Commented Repertory of Drugs--1997", according to their effect on driving performance. The categorisation was based on literature da...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:

    authors: Maes V,Grenez O,Charlier C,Smet H,Verstraete A,Wennig R

    更新日期:1999-01-01 00:00:00

  • A rare cause of severe recurrent abdominal pain.

    abstract::Recurrent abdominal pain may be enigmatic to solve. We report three cases, presenting after a protracted history of severe recurrent bouts of epigastric pain, impeding daily activities. In all cases, serology for strongyloidiasis stercoralis proved positive. In one case, stool examination was positive for larvae. Trea...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.68.1.2062725

    authors: Isen C,Ivens C,Callens SF,Meeuwissen J,Vonck A,Koch A,Vogelaers D

    更新日期:2013-01-01 00:00:00

  • [Wegener's granulomatosis: clinical, radiological and diagnostic characteristics. Apropos of a case].

    abstract::The authors report an observation of Wegener's granulomatosis with pulmonary, bronchial, renal, cutaneous and sinusal involvement. Five years ago, the patient was referred to us because of bilateral diffuse pulmonary infiltrates of unknown origin. A corticotherapy was introduced at that time and a complete clearance o...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1995.11718464

    authors: Polus M,Hamels J,Dorzee J,Henkinbrant A,Carlier B,d'Odemont JP

    更新日期:1995-01-01 00:00:00

  • Fatal multiple coronary involvements in a young woman with systemic lupus erythematosus.

    abstract::We report a rare case of fulminant congestive heart failure with fatal outcome in a 21-year-old girl with systemic lupus erythematosus (SLE). A young woman was admitted in the intensive care unit for pericardial tamponade associated with disseminated coagulopathy and refractory shock secondary to multiple coronary ane...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/2295333714Y.0000000063

    authors: Ha Vu N,Duttmann R,De Bels D,Devriendt J,Reper P

    更新日期:2014-12-01 00:00:00

  • Subacute endocarditis due to Erysipelothrix rhusiopathiae.

    abstract::Erysipelothrix rhusiopathiae is a rare cause of endocarditis. Most cases were observed in people working with animals. We report a case in a 45-year old man without any exposure to animals. He was admitted to our hospital because of dyspnoea. Blood cultures were drawn following fever on day 8 of hospitalisation. Erysi...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2003.58.6.006

    authors: Spiritus T,Surmont I

    更新日期:2003-11-01 00:00:00

  • Time course of iron metabolism in critically ill patients.

    abstract:BACKGROUND:Altered iron metabolism plays a central role in the development of anaemia in critically ill patients but the time course of iron status in septic and non-septic critically ill patients has not been well defined. METHODS:Prospective study in a 34-bed medico-surgical ICU. The complete blood count, iron, ferr...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.68.1.2062715

    authors: Piagnerelli M,Cotton F,Herpain A,Rapotec A,Chatti R,Gulbis B,Vincent JL

    更新日期:2013-01-01 00:00:00

  • Diabetes and the endothelium.

    abstract::Abnormal endothelial function plays a pivota role in the pathogenesis of diabetic complications. Due to lack of autoregulation of glucose transport in the presence of high extracellular glucose concentrations, intracellular hyperglycaemia induces a series of metabolic changes that ultimately lead to the genesis of bot...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2007.017

    authors: Hermans MP

    更新日期:2007-03-01 00:00:00

  • Plasma D-dimer concentrations in different clinical conditions.

    abstract::D-dimers (DD), specific degradation products of crosslinked fibrin, are markers for activation of plasma coagulation and/or fibrinolysis. DD results below the cut-off level are proven to be useful to rule out the probable diagnosis of deep venous thrombosis (DVT) and/or pulmonary embolism (PE). Our objective was to de...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2002.060

    authors: Ver Elst K,Jochmans K,De Pauw A,De Waele M

    更新日期:2002-11-01 00:00:00

  • Intrapancreatic accessory spleen mimicking pancreatic NET: can unnecessary surgery be avoided?

    abstract::Pancreatic nodules are frequently found incidentally and often pose a diagnostic and therapeutic challenge when surgery is considered. We present the case of a 66-year-old cirrhotic patient with a pancreatic nodule with signal intensity and contrast enhancement pattern suggestive for a non-functional neuroendocrine le...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2020.1762351

    authors: Vandekerckhove E,Ameloot E,Hoorens A,De Man K,Berrevoet F,Geboes K

    更新日期:2020-05-12 00:00:00