Belgian multicentre study on the in vitro activity of cefepime against gram-negative bacilli.

Abstract:

:The in vitro activity of cefepime has been compared with that of cefotaxime, ceftazidime, aztreonam, and piperacillin against 1826 Enterobacteriaceae including 537 inducible Enterobacteriaceae (Enterobacter spp., Serratia spp., Citrobacter spp,. Morganella morganii) and 572 non-fermenters, including 401 Pseudomonas aeruginosa and 111 Acinebacter spp. isolated from hospitalized patients in 28 Belgian hospitals. Overall, cefepime was found substantially more active than the third-generation cephalosporins, aztreonam and piperacillin against Enterobacteriaceae species producing inducible type I cephalosporinases. Notably, cefepime remained active against 96% of Enterobacteriaceae resistant to cefotaxime, ceftazidime or aztreonam while it displayed a similar activity against E. coli and the other Enterobacteriaceae. Against non-fermenters, cefepime was found less active than ceftazidime but more than cefotaxime or aztreonam.

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

Verbist L,Glupczynski Y

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

28-35

issue

1

eissn

1784-3286

issn

2295-3337

journal_volume

51

pub_type

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