Abstract:
:The availability of antiretroviral therapy (ART) has significantly improved the quality of life of persons with HIV infection. However, new problems have arisen as a consequence of this treatment. An immune reconstitution inflammatory syndrome (IRIS) in which patients experience a paradoxical worsening of their clinical condition may occur during recovery of the immunity. Thus far, there is no laboratory test available to diagnose IRIS. The diagnosis therefore remains clinical and by exclusion. In this paper, we describe the autopsy findings of three HIV-infected patients who died at the Antwerp University hospital directly or indirectly related to IRIS. One patient died following a disseminated cryptococcocal and Mycobacterium avium complex (MAC) infection. Two other patients died with a disseminated aspergillosis infection after receiving corticosteroids to decrease IRIS induced inflammatory signs. These three patients show the difficulties faced by clinicians in diagnosing IRIS and the importance of performing autopsies in persons with HIV infection who die despite receiving ART.
journal_name
Acta Clin Belgjournal_title
Acta clinica Belgicaauthors
Huis in 't Veld D,Lukande R,Lammens M,Conesa-Botella A,Vlieghe E,Van Marck E,Pauwels P,Colebunders Rdoi
10.2143/ACB.3281subject
Has Abstractpub_date
2013-07-01 00:00:00pages
294-7issue
4eissn
1784-3286issn
2295-3337journal_volume
68pub_type
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journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1996.11718509
更新日期:1996-01-01 00:00:00
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journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/0001551214Z.00000000035
更新日期:2014-04-01 00:00:00
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journal_title:Acta clinica Belgica
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:
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journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1080/17843286.1995.11718464
更新日期:1995-01-01 00:00:00
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journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2007.027
更新日期:2007-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Acta clinica Belgica
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1179/acb.2009.051
更新日期:2009-07-01 00:00:00
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更新日期:2002-01-01 00:00:00
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journal_title:Acta clinica Belgica
pub_type: 杂志文章
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doi:10.1179/acb.2005.034
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pub_type: 社论
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journal_title:Acta clinica Belgica
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journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/2295333714Y.0000000114
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