HbSC hemoglobinopathy suspected by chest x-ray and red blood cell morphology.

Abstract:

:Thorax scan was performed for elucidation of a pulmonary problem in a Nigerian immigrant. The aspect of the vertebrae suggested sickle cell disease, of course without specification of the genotype. Routine hematological tests seemed compatible with an HbSC disease, showing typical laboratory features, namely a significant proportion of hyperchromic RBC, corresponding to secondary, non hereditary spherocytosis, presence of numerous target cells and occasional HbC crystals on Pappenheim stained blood films. The diagnosis of HbSC disease was confirmed by HPLC, iso-electric focusing and citrate agar electrophoresis of hemoglobin and by reverse phase HPLC of globin-chains. This case illustrates the importance of screening for hemoglobin anomalies as it is performed in a multiethnic country such as the Grand Duchy of Luxembourg

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

Thoma J,Kutter D,Casel S,Rosoux P,Braas C,Ries F,Groff P,Kalmes G,Golinska B

doi

10.1179/acb.2005.057

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

377-82

issue

6

eissn

1784-3286

issn

2295-3337

journal_volume

60

pub_type

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