Doxycycline and hepatotoxicity.

Abstract:

:The hepatotoxicity of tetracyclines is well known. If microvesicular steatosis due to a high dose of tetracycline has virtually disappeared, it can also be observed with other drugs belonging to the tetracycline family. To our knowledge, hepatotoxicity induced by doxycycline has never been reported. In our patient, the abrupt onset of hepatic failure, five days after the start of doxycycline and the rapid normalization after the drug was stopped, leads to suspect a causal relationship between doxycycline and liver insufficiency. We must however be careful before concluding, because our patient received also acetylsalicylic acid and paracetamol, two other potential hepatotoxic drugs.

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

Lienart F,Morissens M,Jacobs P,Ducobu J

doi

10.1080/17843286.1992.11718230

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

205-8

issue

3

eissn

1784-3286

issn

2295-3337

journal_volume

47

pub_type

杂志文章
  • Comparison between classical polyarteritis nodosa and single organ vasculitis of medium-sized vessels: a retrospective study of 25 patients and review of the literature.

    abstract:BACKGROUND:Polyarteritis nodosa (PAN) is a rare form of systemic vasculitis, characterized by necrotizing inflammation of medium-sized vessels. In clinical practice, the distinction is made between a limited, mostly cutaneous, form and a generalized form. The Chapel Hill Consensus Conference of 2012 on the classificati...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/2295333714Y.0000000114

    authors: Kint N,De Haes P,Blockmans D

    更新日期:2016-02-01 00:00:00

  • QTc ınterval is prolonged in Wilson's disease with neurologic ınvolvement.

    abstract::Background Neurologic and liver involvement in Wilson's disease (WD) is well-documented, however, few reports demonstrated cardiac involvement. Tpe and Tpe/QT are new measures of ventricular repolarization which were recently suggested as predictor of arrythmogenesis. We aimed to evaluate ventricular depolarization an...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2018.1443001

    authors: Ozturk S,Gurbuz AS,Efe SC,Iliaz R,Banzragch M,Demir K

    更新日期:2018-10-01 00:00:00

  • Meningitis caused by Campylobacter jejuni: a case presentation and literature review.

    abstract::Objectives: Campylobacter jejuni is one of the most common causative agents of gastroenteritis; however C. jejuni meningitis is rarely described. Therefore, little is known about its epidemiology, clinical presentation, diagnostic methods, treatment, and outcomes.Methods: In this paper, we report a case of an adult pa...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2020.1721133

    authors: Kusulja M,Santini M,Margetić K,Guzvinec M,Šoprek S,Butić I,Tambić Andrašević A

    更新日期:2020-01-28 00:00:00

  • Rapid diagnosis of viral respiratory infections. Comparison between immunofluorescence on clinical samples and immunofluorescence on centrifuged cell cultures.

    abstract::We compared the technique of immunofluorescence on clinical samples (IFCS) and immunofluorescence on centrifuged cell cultures (IFCC) for the detection of respiratory viruses, using monoclonal antibodies. Four hundred fourty five nasopharyngeal aspirates were tested prospectively for RSV, influenza- (A and B), parainf...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1991.11718134

    authors: Pattyn SR,Provinciael D,Lambrechts R,Ceuppens P

    更新日期:1991-01-01 00:00:00

  • Metformin and lactic acidosis in patients with type 2 diabetes--from pride and prejudice to sense and sensibility.

    abstract:AIM:To present the cases of lactic acidosis encountered in our department among metformin-treated type 2 diabetic patients and to investigate the role of contraindications to metformin use. METHODS:A survey of medical records of metformin-treated type 2 diabetic patients hospitalised for various medical conditions dur...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2009.008

    authors: Papanas N,Monastiriotis C,Christakidis D,Maltezos E

    更新日期:2009-01-01 00:00:00

  • Prevention and treatment of thromboembolic events in medical patients and new anticoagulants.

    abstract::VTE presents a significant clinical and economic burden on healthcare. Previous strategies (chemical and mechanical) were not full-proof when used in isolation. The advent of more recent treatments such as factor Xa inhibitors and direct thrombin inhibitors may help to provide more conclusive preventative management o...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2009.093

    authors: Balaratnam S

    更新日期:2009-11-01 00:00:00

  • Management of acute ischaemic stroke.

    abstract::Over the past few years there have been enormous changes in the management of stroke patients. General practitioners, ambulance personnel/paramedics and the general public need to be well informed that stroke is a medical emergency. Prevention of secondary brain damage by normalising vital parameters and combating fev...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1999.11754250

    authors: De Keyser J,Sulter G,Langedijk M,Elting JW,van der Naalt J

    更新日期:1999-10-01 00:00:00

  • Repetitive analyses of P-glycoprotein in chronic myeloid leukaemia.

    abstract::P-glycoprotein, a pump located in the plasma cell membrane, extrudes several clinically important drugs from the cell, and hence causes multidrug resistance. Reversing clinical drug resistance is possible by using agents that inhibit the activity of P-glycoprotein. We describe the results of sequential flow cytometric...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2000.11754299

    authors: De Moerloose B,Muylaert A,Gemmel F,Janssens A,Poppe B,Dhooge C,Benoit Y,Van Hove W,Philippé J

    更新日期:2000-07-01 00:00:00

  • Successful fibrinolytic treatment of prosthetic heart valve thrombosis using streptokinase.

    abstract:OBJECTIVES:This study aims to evaluate the clinical outcome of fibrinolytic treatment of prosthetic valve thrombosis (PVT) with 'streptokinase' as a first line treatment for these cases. METHODS:The study group was 20 consecutive patients (10 females) diagnosed with PVT. The protocol for streptokinase administration w...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/2295333714Y.0000000107

    authors: Sakr SA,Abdel-Shakour H,Ramadan MM

    更新日期:2015-06-01 00:00:00

  • Disseminated histoplasmosis: case report and review of the literature.

    abstract::Case report We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest radiography revealed a 'miliary pattern'. Bone marrow aspiration pointed out yeast inclusions within macrophages. Giv...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.2017.1376454

    authors: Evrard S,Caprasse P,Gavage P,Vasbien M,Radermacher J,Hayette MP,Sacheli R,Van Esbroeck M,Cnops L,Firre E,Médart L,Moerman F,Minon JM

    更新日期:2018-10-01 00:00:00

  • Infective endocarditis.

    abstract::The diagnosis of infective endocarditis remains difficult. The complication rate is very high. Serious complications may occur and the overall mortality is still 20-25%. The sooner the treatment is started, the better the final result. Antibiotic therapy is essential but cardiac surgery is frequently necessary. Early ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2008.085

    authors: Herregods MC,Hill E,Herijgers P,De Munter P,Vanderschueren S,Van Wijngaerden E,Peetermans WE

    更新日期:2008-11-01 00:00:00

  • The immune reconstitution inflammatory syndrome: a cause of death in persons on antiretroviral therapy?

    abstract::The availability of antiretroviral therapy (ART) has significantly improved the quality of life of persons with HIV infection. However, new problems have arisen as a consequence of this treatment. An immune reconstitution inflammatory syndrome (IRIS) in which patients experience a paradoxical worsening of their clinic...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.3281

    authors: Huis in 't Veld D,Lukande R,Lammens M,Conesa-Botella A,Vlieghe E,Van Marck E,Pauwels P,Colebunders R

    更新日期:2013-07-01 00:00:00

  • Antineutrophil cytoplasmic antibodies (ANCA) and small vessel vasculitis.

    abstract::We report on one patient with Wegener's granulomatosis (WG) and two patients with microscopic polyangiitis (MPA). The patient with WG had signs of a respiratory infection and showed a c-ANCA pattern with proteinase 3 (PR3) specificity. The patients with MPA presented with pulmonary haemorrhage and signs of renal damag...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2003.58.3.008

    authors: Mareen P,Van De Walle S,Bernaert P,Vanhouteghem H,Dierick J

    更新日期:2003-05-01 00:00:00

  • Hospital-acquired infections in Belgian acute-care hospitals: financial burden of disease and potential cost savings.

    abstract:INTRODUCTION:Hospital Acquired Infections (HAIs) are considered to be one of the most serious patient safety issues in healthcare today. It has been shown that HAIs contribute significantly not only to morbidity and mortality, but also to excessive costs for the health care system and for hospitalized patients. Since p...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.3258

    authors: Trybou J,Spaepen E,Vermeulen B,Porrez L,Annemans L

    更新日期:2013-05-01 00:00:00

  • Prevention of hepatitis B infections: vaccination and its limitations.

    abstract::Infection with hepatitis B virus has become a vaccine-preventable disease. The recombinant hepatitis B vaccines available today are safe and immunogenic. In order for these vaccines to eradicate HBV a universal vaccination of neonates and/or children needs to be implemented. Major obstacles on the road to global hepat...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2001.032

    authors: Leroux-Roels G,Cao T,De Knibber A,Meuleman P,Roobrouck A,Farhoudi A,Vanlandschoot P,Desombere I

    更新日期:2001-07-01 00:00:00

  • Long-term effects of gastric bypass surgery on psychosocial well-being and eating behavior: not all that glitters is gold.

    abstract:OBJECTIVES:The aim of this pilot study was to evaluate long-term effects of Roux-en-Y gastric bypass (RYGB) on physical and psychosocial health as well as eating behavior of obese patients. METHODS:We compared 23 patients 7 years after RYGB to 23 body mass index (BMI), sex, and age matched obese control patients by me...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2016.1174393

    authors: Vangoitsenhoven R,Frederiks P,Gijbels B,Lannoo M,Van der Borght W,Van den Eynde A,Mertens A,Mathieu C,Van der Schueren B

    更新日期:2016-12-01 00:00:00

  • Repair for partial and complete atrioventricular septal defect: single centre experience and long-term results.

    abstract:BACKGROUND:The number of adult patients with surgical repaired congenital heart defects increases continuously. We were interested to compare late outcome after partial and complete atrioventricular defect repair (pAVSD and cAVSD, respectively) and to determine the most important reason for re-intervention. METHODS:Al...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:

    authors: Soufflet V,Daenen W,Van Deyk K,Troost E,Budts W

    更新日期:2005-09-01 00:00:00

  • Consensus conference definitions and recommendations on intra-abdominal hypertension (iah) and the abdominal compartment syndrome (acs) - the long road to the final publications, how did we get there?

    abstract:OBJECTIVE:There has been an exponentially increasing interest in intraabdominal hypertension (IAH) and the abdominal compartment syndrome (ACS) over the last decade, and different definitions have been suggested. Nevertheless, there has been an impetus from experts in the field to modify these definitions to reflect ou...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2007.62.s1.007

    authors: Malbrain ML,De Laet I,Cheatham M

    更新日期:2007-01-01 00:00:00

  • Management of refractory systemic rheumatic diseases.

    abstract::The management of refractory systemic rheumatic diseases remains a challenging issue. New immunosuppressive drugs have been developed which might improve long-term outcome, with a reasonably toxicity profile. Moreover, better understanding of the mechanisms underlying some of the systemic rheumatic disease has raised ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2003.58.5.009

    authors: Houssiau FA

    更新日期:2003-09-01 00:00:00

  • Behçet's disease; A rare refractory patient with vena cava superior syndrome treated with infliximab: a case report and review of the literature.

    abstract::Objectives: Behçet's disease (BD) is a multi-systemic inflammatory disorder which can affect all types and sizes of vessels.The usage of TNF-α antagonists is increasing in different involvements of BD that is inadequately controlled by standard immunosuppressive regimens. Methods: Here we reported a rare BD case that ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.2018.1522020

    authors: Uyaroglu OA,Erden A,Kilic L,Peynircioğlu B,Karadag O,Kalyoncu U

    更新日期:2019-10-01 00:00:00

  • A lady with NASH and choreoathetosis.

    abstract::We describe a case of acquired hepatocerebral degeneration (AHD) presenting with confusion and worsening memory problems since her discharge from the gastroenterology units. Cases of AHD are rare and are frequently confused with hepatic encephalopathy and Wilson's disease. There are no proven pharmacological therapies...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/2295333715Y.0000000027

    authors: Ghys C,Kong MF,Glibert G,Lasser L,Karmali R

    更新日期:2015-10-01 00:00:00

  • Comparisons between psychotropic drugs: must the risk of side effects dictate our practices?

    abstract:OBJECTIVES:Recently, SOHO and CATIE's studies in the field of schizophrenic disorders asserted that molecules apparently showing the most side-effects are not only the most effective but also lead to the least changes in treatments. Can we generalise this assertion to other domains of pharmacological treatments, such a...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2008.043

    authors: Zdanowicz N,Jacques D,Reynaert C

    更新日期:2008-07-01 00:00:00

  • Intrapancreatic accessory spleen mimicking pancreatic NET: can unnecessary surgery be avoided?

    abstract::Pancreatic nodules are frequently found incidentally and often pose a diagnostic and therapeutic challenge when surgery is considered. We present the case of a 66-year-old cirrhotic patient with a pancreatic nodule with signal intensity and contrast enhancement pattern suggestive for a non-functional neuroendocrine le...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2020.1762351

    authors: Vandekerckhove E,Ameloot E,Hoorens A,De Man K,Berrevoet F,Geboes K

    更新日期:2020-05-12 00:00:00

  • The use of hypnosedative drugs in a university hospital setting.

    abstract:OBJECTIVE:The use of hypnosedatives (HSs) in the hospital and at home before admission was registered. Also, the incidence of HSs newly started in the hospital and the incidence of withdrawal in chronic users while in hospital was recorded. METHODS:The study population consisted of 517 consecutively admitted patients ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2003.58.4.003

    authors: Warie H,Petrovic M,Somers A,Mariman A,Robays H,Pevernagie D

    更新日期:2003-07-01 00:00:00

  • The haemophagocytic syndrome.

    abstract::The haemophagocytic syndrome or haemophagocytic lymphohistiocytosis (HLH) is a syndrome encompassing a heterogeneous group of disorders characterized by a persistent activation of benign macrophages, leading to uncontrolled secretion of cytokines and phagocytosis of blood cells. The syndrome can be primary due to muta...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.2143/ACB.66.6.2062613

    authors: Dierickx D,Cortoos A,Vanderschueren S

    更新日期:2011-11-01 00:00:00

  • [Study of a group of diabetic patients enrolled in the INAMI convention "Self-monitoring of blood glucose"].

    abstract::We have studied the clinical characteristics of 126 insulin-treated diabetic patients, mainly type I subjects, who regularly performed during 18 months home glucose monitoring. The numbers of strips used each month was of 60 +/- 33 (mean +/- lSD). During the study period, HbA1C levels decreased from 8.6 +/- 2.1 to 7.0...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1993.11718324

    authors: Buysschaert M,Lambert L,Donckier J,Jamart J

    更新日期:1993-01-01 00:00:00

  • Recovery of pulmonary and skin lesions of sarcoidosis after thymectomy.

    abstract:OBJECTIVE AND IMPORTANCE:Sarcoidosis is a multisystem inflammatory disorder of unknown etiology. It is characterized by the presence of noncaseating granulomas and an inflammatory process in which T lymphocytes, especially type-1 helper T (Th1) cells, macrophages and different cytokines are involved. Different studies ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2016.1152671

    authors: Esendagli D,Koksal D,Emri S

    更新日期:2016-12-01 00:00:00

  • Epidemiology of type 1 and type 2 diabetes. The added value of diabetes registries for conducting clinical studies: the Belgian paradigm.

    abstract::Diabetes registries have documented that the lifetime risk of diabetes amounts to at least 10% in the western world. Moreover the prevalence of type 2 diabetes is increasing worldwide especially in developing countries. Furthermore there is a secular trend toward earlier clinical manifestation of both type 1 and type ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2004.001

    authors: Gorus FK,Weets I,Couck P,Pipeleers DG,Belgian Diabetes Registry.

    更新日期:2004-01-01 00:00:00

  • Noosa, 2 years later... a critical analysis of recent literature.

    abstract:INTRODUCTION:Since the second World Congress on the Abdominal Compartment Syndrome (WCACS) in Noosa 2 years ago, interest and publications on intra-abdominal hypertension (IAH) and ACS have increased exponentially. This paper aimed to critically review recent publications and put this new data into the context of alrea...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:

    authors: Wauters J,Wilmer A

    更新日期:2007-01-01 00:00:00

  • Cause D'Erreur Dans La Lecture Des Antibiogrammes : Présence, Non Déclarée, D'Un Antiseptique Sur Les Disques.

    abstract::There is a need for legal control of sensitivity discs. False results are obtained by the use of discs containing an antibiotic and an unlabelled antimicrobial drug. Results of sensitivity tests (performed by the disc agar diffusion method) using Levocyclin8 discs furnished by the manufacturers were highly improbable....

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1976.11717057

    authors: Yourassowsky E,Dony J,De Roeck A,De Keere V,Schoutens E,Vanderlinden MP,Palsterman V

    更新日期:1976-01-01 00:00:00