Repetitive analyses of P-glycoprotein in chronic myeloid leukaemia.

Abstract:

:P-glycoprotein, a pump located in the plasma cell membrane, extrudes several clinically important drugs from the cell, and hence causes multidrug resistance. Reversing clinical drug resistance is possible by using agents that inhibit the activity of P-glycoprotein. We describe the results of sequential flow cytometric determinations of P-glycoprotein expression and activity in two patients suffering from acute lymphoblastic transformation of chronic myeloid leukaemia. Neither P-glycoprotein expression, nor its activity could be detected in the initial sample of the first patient. In the second patient, no P-glycoprotein expression was found at diagnosis. However, after chemotherapy containing P-glycoprotein substrates, a significant expression was found in both patients and the functional flow cytometric test was positive. In order to achieve an accurate selection of patients that might benefit from the clinical use of P-gp inhibitors, repeated analyses are indicated in each patient suffering from acute leukaemia, during the course of the illness.

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

De Moerloose B,Muylaert A,Gemmel F,Janssens A,Poppe B,Dhooge C,Benoit Y,Van Hove W,Philippé J

doi

10.1080/17843286.2000.11754299

keywords:

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

215-21

issue

4

eissn

1784-3286

issn

2295-3337

journal_volume

55

pub_type

杂志文章
  • The abdominal compartment syndrome in patients with burn injury.

    abstract:INTRODUCTION:Intra-abdominal hypertension (IAH) and subsequent abdominal compartment syndrome (ACS) in burned patients is common. This sequence of events typically occurs in patients with larger burns receiving high volume fluid resuscitation. METHODS:A review of the literature was performed. The National Library of M...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2007.62.s1.017

    authors: Tuggle D,Skinner S,Garza J,Vandijck D,Blot S

    更新日期:2007-01-01 00:00:00

  • Ascaris lumbricoides: challenges in diagnosis, treatment and prevention strategies in a European refugee camp.

    abstract:OBJECTIVES: The roundworm Ascaris lumbricoides is one of the most prevalent parasites belonging to the class of the soil-transmitted helminths. Infections are most common in developing countries with a tropical climate where sanitation and hygiene are poor. However, prevalence of ascariasis in industrialized countries ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2018.1436956

    authors: Claus PE,Ceuppens AS,Cool M,Alliet G

    更新日期:2018-12-01 00:00:00

  • Short-term return visits of 'general internal medicine' patients to the emergency department: extent and risk factors.

    abstract:OBJECTIVES:Although emergency department (ED) return visits are a significant problem universally, it has not been previously studied in our ED. The aim of this study was to determine the extent of the problem in our ED, to identify the relevant clinical predictor variables and to detect diagnostic errors. METHODS:A r...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2009.069

    authors: Vanbrabant P,Knockaert D

    更新日期:2009-09-01 00:00:00

  • Posterior reversible encephalopathy syndrome: a rare neurological manifestation in Von Hippel-Lindau disease.

    abstract::We report on a 34-year-old woman, who was recently diagnosed with Von Hippel-Lindau disease (VHL), genetically confirmed. At this moment, she presented with an acute history of arterial hypertension, headache, cortical blindness and epilepsy. On the basis of clinical and magnetic resonance imaging (MRI) criteria the d...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2010.060

    authors: Vanacker P,Vanacker A,Leys A,Thijs V

    更新日期:2010-07-01 00:00:00

  • Even if it looks like COVID-19, think again: the importance of differential diagnosis during a pandemic.

    abstract::Introduction:Antisynthetase syndrome (ASSD) is a rare auto-immune condition that can present as interstitial lung disease (ILD) and progress into Acute Respiratory Distress Syndrome (ARDS). Importance:The purpose of this clinical case is to highlight the importance of considering less prevalent causes of ARDS amid the...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2021.1872312

    authors: Van Cauwelaert S,Stylemans D,D'Haenens A,Slabbynck H,Nieuwendijk R

    更新日期:2021-01-15 00:00:00

  • Traitement Des Infections Bronchopulmonaires Aigues Par Le Laurylsulfate De Tetracycline Intra-Musculaire.

    abstract::25 hospitalized patients, suffering from acute bronchopulmonary affections, received every 24 hours, one I.M. injection of 750 mg of tetracycline laurylsulfate (equivalent to 500 mg of tetracycline HCl). Positive clinical results were obtained in all cases. All isolated micro-organisms, sensitive in vitro to tetracycl...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1972.11716815

    authors: Sternon J,de Hemptinne J,Sergysels R,Butzler JP,Yourassowsky E

    更新日期:1972-01-01 00:00:00

  • Relapse of a renal inflammatory pseudotumour associated with Wegener's granulomatosis.

    abstract::We report the case of a 32-year-old patient with Wegener's granulomatosis (WG) associated with a (biopsy - proven) renal inflammatory pseudotumour (IPT) of the left kidney treated by a partial nephrectomy, glucocorticoids and immunosuppressive drugs, in whom a relapse of renal IPT was found 6 years after the diagnosis...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2010.65.6.011

    authors: Vandergheynst F,Dumarey N,Cogan E

    更新日期:2010-11-01 00:00:00

  • The use of uHear™ to screen for hearing loss in older patients with cancer as part of a comprehensive geriatric assessment.

    abstract:OBJECTIVE:We previously validated uHear™ to screen for hearing loss in older patients with cancer without a known hearing loss, as part of a comprehensive geriatric assessment (CGA). In view of low specificity, we tested a new modified uHear™ scoring system as described by Handzel. METHODS:Patients, aged ≥70 years, we...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2017.1392070

    authors: Lycke M,Debruyne PR,Lefebvre T,Martens E,Ketelaars L,Pottel H,Van Eygen K,Derijcke S,Werbrouck P,Vergauwe P,Stellamans K,Clarysse P,Dhooge I,Schofield P,Boterberg T

    更新日期:2018-04-01 00:00:00

  • Antineutrophil cytoplasmic antibodies (ANCA) and small vessel vasculitis.

    abstract::We report on one patient with Wegener's granulomatosis (WG) and two patients with microscopic polyangiitis (MPA). The patient with WG had signs of a respiratory infection and showed a c-ANCA pattern with proteinase 3 (PR3) specificity. The patients with MPA presented with pulmonary haemorrhage and signs of renal damag...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2003.58.3.008

    authors: Mareen P,Van De Walle S,Bernaert P,Vanhouteghem H,Dierick J

    更新日期:2003-05-01 00:00:00

  • Invasive pulmonary aspergillosis due to a multi-azole resistant Aspergillus fumigatus.

    abstract::A patient with invasive pulmonary aspergillosis due to an azole-resistant Aspergillus fumigatus is described. Despite treatment change from voriconazole to amphotericin B as soon as the resistance data were available, the patient died. Azole resistance is an emerging problem, which significantly complicates the manage...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.67.1.2062627

    authors: Jeurissen A,Cooreman S,Van Kerckhoven W,Van Leemput J,Vanhove P,Lagrou K,Heytens L

    更新日期:2012-01-01 00:00:00

  • Molecular profiling in lung cancer associated with cystic airspaces.

    abstract::'Lung cancer associated with cystic airspaces' is a rare radiological entity that is more frequently encountered on imaging studies and is gaining more attention since the widespread use of CT for lung cancer screening. Numerous aspects of this entity remain unraveled, including molecular profiling. The goal of this o...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2019.1680134

    authors: Snoeckx A,Reyntiens P,Pauwels P,Van Schil PE,Parizel PM,Van Meerbeeck JP

    更新日期:2019-10-15 00:00:00

  • Atypical presentation of acute coronary syndrome (ACS): a case report.

    abstract:CASE:A 45-year-old man presented at the emergency department (ED) with stomach pain since eight days. The patient was not worried about his symptoms and requested only pain relief. The emergency physician requested a consult of the gastroenterologist. Clinical examination was unremarkable. However, 12-lead ECG and isch...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2018.1460019

    authors: Van Damme A,Vanderheeren P,De Backer T,Desimpel F

    更新日期:2018-12-01 00:00:00

  • The immune reconstitution inflammatory syndrome: a cause of death in persons on antiretroviral therapy?

    abstract::The availability of antiretroviral therapy (ART) has significantly improved the quality of life of persons with HIV infection. However, new problems have arisen as a consequence of this treatment. An immune reconstitution inflammatory syndrome (IRIS) in which patients experience a paradoxical worsening of their clinic...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.3281

    authors: Huis in 't Veld D,Lukande R,Lammens M,Conesa-Botella A,Vlieghe E,Van Marck E,Pauwels P,Colebunders R

    更新日期:2013-07-01 00:00:00

  • An inquiry on pain management in the emergency department of training hospitals.

    abstract:INTRODUCTION:Improving pain management in the ED might be attained by adequate teaching of medical students. We assessed the skills in pain treatment of ED physicians who teach the students. METHODS:All physicians working in an ED who provide elective training to undergraduate medical students from the Ghent Universit...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.66.6.2062603

    authors: Lemoyne S,De Paepe P,Vankeirsbilck C,Buylaert W

    更新日期:2011-11-01 00:00:00

  • Disseminated histoplasmosis: case report and review of the literature.

    abstract::Case report We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest radiography revealed a 'miliary pattern'. Bone marrow aspiration pointed out yeast inclusions within macrophages. Giv...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.2017.1376454

    authors: Evrard S,Caprasse P,Gavage P,Vasbien M,Radermacher J,Hayette MP,Sacheli R,Van Esbroeck M,Cnops L,Firre E,Médart L,Moerman F,Minon JM

    更新日期:2018-10-01 00:00:00

  • Multicentric reticulohistiocytosis associated arthritis responding to anti-TNF and methotrexate.

    abstract::We present a patient with therapy resistant multicentric reticulohistiocytosis (MRH). MRH is a rare granulomatous, multisystem disease characterised most frequently by disfiguring papulonodular skin lesions and sometimes a destructive polyarthritis, though any organ can be involved. Abnormal histiocytic reactions to a...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.66.1.2062520

    authors: De Knop KJ,Aerts NE,Ebo DG,Van Offel JF,Stevens WJ,De Clerck LS

    更新日期:2011-01-01 00:00:00

  • [Study of a group of diabetic patients enrolled in the INAMI convention "Self-monitoring of blood glucose"].

    abstract::We have studied the clinical characteristics of 126 insulin-treated diabetic patients, mainly type I subjects, who regularly performed during 18 months home glucose monitoring. The numbers of strips used each month was of 60 +/- 33 (mean +/- lSD). During the study period, HbA1C levels decreased from 8.6 +/- 2.1 to 7.0...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1993.11718324

    authors: Buysschaert M,Lambert L,Donckier J,Jamart J

    更新日期:1993-01-01 00:00:00

  • Severity of liver echogenicity is correlated to serum c-peptide levels in type 2 diabetic patients.

    abstract:AIM:To investigate the correlation between liver echogenicity and serum C-peptide levels in type 2 diabetic patients treated with oral hypoglycaemic agents. PATIENTS AND METHODS:The study included 231 type 2 diabetic patients (114 men) with a mean age of 64.3 +/- 6.9 years and a mean diabetes duration of 8.5 +/- 3.2 y...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2006.002

    authors: Papanas N,Symeonidis G,Mavridis G,Papazoglou D,Giannakis I,Papatheodorou K,Pastore F,Lakasas G,Maltezos E

    更新日期:2006-01-01 00:00:00

  • Does serum 25 hydroxy vitamin D level predict disease activity in ulcerative colitis patients?

    abstract:BACKGROUND/AIM:There are controversial results regarding the relationship of serum 25 hydroxy vitamin D [25(OH)D] and ulcerative colitis (UC) activity. To address this issue, the current study was designed to evaluate the correlation of serum 25(OH)D level and disease activity in patients with UC. METHOD:All consecuti...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2015.1110895

    authors: Dolatshahi S,Pishgar E,Jamali R

    更新日期:2016-02-01 00:00:00

  • How to treat a fulminant erysipelas and sepsis caused by Myroides odoratimimus: case report and literature review.

    abstract::We report a case of a 77-year old male who developed a fulminant erysipelas and sepsis, caused by Myroides odoratimimus. Selecting the optimal antibiotic therapy for the treatment of infections with M. odoratimimus is challenging due to limited clinical experience with this micro-organism and its reported multidrug-re...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.2016.1245173

    authors: Willems P,Muller J,Verhaegen J,Saegeman V,Desmet S

    更新日期:2017-10-01 00:00:00

  • Infective endocarditis.

    abstract::The diagnosis of infective endocarditis remains difficult. The complication rate is very high. Serious complications may occur and the overall mortality is still 20-25%. The sooner the treatment is started, the better the final result. Antibiotic therapy is essential but cardiac surgery is frequently necessary. Early ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2008.085

    authors: Herregods MC,Hill E,Herijgers P,De Munter P,Vanderschueren S,Van Wijngaerden E,Peetermans WE

    更新日期:2008-11-01 00:00:00

  • Flow-assisted basophil activation tests in immediate drug hypersensitivity: two decades of Antwerp experience.

    abstract::The last two decades have witnessed that flow-assisted analysis of in vitro-activated basophils can constitute a valuable adjunct in the in vitro diagnostic approach of immediate drug hypersensitivity reactions (IDHR). This article summarises the current experience with the basophil activation test in the diagnosis of...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.2015.1122871

    authors: Mangodt EA,Van Gasse AL,Bastiaensen A,Decuyper II,Uyttebroek A,Faber M,Sabato V,Bridts CH,Hagendorens MM,De Clerck LS,Ebo DG

    更新日期:2016-02-01 00:00:00

  • The Diabetic Foot Project of Flanders, the northern part of Belgium: implementation of the St Vincent consensus. Sensibilisation and registration in diabetes centres.

    abstract::As a result of the St Vincent declaration, a Belgian "task force" was installed in 1992 and consequently 16 working groups were formed. They presented their objectives in 1995. The working group "prevention and treatment of diabetic foot lesions" started the implementation of a screening program to obtain an overview ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,多中心研究

    doi:10.1179/acb.2001.005

    authors: Van Acker K,Weyler J,De Leeuw I

    更新日期:2001-01-01 00:00:00

  • Comparisons between psychotropic drugs: must the risk of side effects dictate our practices?

    abstract:OBJECTIVES:Recently, SOHO and CATIE's studies in the field of schizophrenic disorders asserted that molecules apparently showing the most side-effects are not only the most effective but also lead to the least changes in treatments. Can we generalise this assertion to other domains of pharmacological treatments, such a...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2008.043

    authors: Zdanowicz N,Jacques D,Reynaert C

    更新日期:2008-07-01 00:00:00

  • Role of hepatic arterial embolisation in the treatment for metastatic insulinoma. Report of two cases and review of the literature.

    abstract::Malignant insulinomas are very rare. They have typical clinical and biochemical characteristics that allow an early detection and distinction from other sorts of islet cell carcinoma. As a result a curative resection can occasionally be managed. Nevertheless, for more advanced stages the same treatment options as for ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1997.11718588

    authors: Berwaerts J,Verhelst J,Hubens H,Kunnen J,Schrijvers D,Joosens E,Mahler C,Van Gaal L

    更新日期:1997-01-01 00:00:00

  • Simultaneous determination of seven azole antifungal drugs in serum by ultra-high pressure liquid chromatography and diode array detection.

    abstract::Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major active metabolite, hydroxy-itraconazole) in serum can be usef...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/0001551213Z.00000000018

    authors: Mistretta V,Dubois N,Denooz R,Charlier C

    更新日期:2014-01-01 00:00:00

  • Oral cephalosporins.

    abstract::The arrival of new cephalosporins faces the clinician with an evergrowing confusion as to the drug of choice. The older agents (cephalexin, cephradine, cefadroxil and cefaclor) and the newer formulations cefatrizine and cefuroxime axetil are intensively used for treatment of mild and moderate infections. The oldest ag...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1992.11718259

    authors: Verhaegen J,Verbist L

    更新日期:1992-01-01 00:00:00

  • Mycobacterium marinum infection causing extensive tissue destruction in a hypoxic COPD patient.

    abstract::We report a skin Mycobacterium marinum infection presenting as wide ulcerative lesions of the arm (4 cm for the widest) in a hypoxic COPD patient who takes 4 mg methylprednisolone daily and higher doses during exacerbations. Diagnostic delay as well as glucocorticoid use could be responsible for the extension of the l...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.66.4.2062576

    authors: Buttafuoco F,Peché R,Vander Elst B,Van Meerhaeghe A

    更新日期:2011-07-01 00:00:00

  • Prevention of hepatitis B infections: vaccination and its limitations.

    abstract::Infection with hepatitis B virus has become a vaccine-preventable disease. The recombinant hepatitis B vaccines available today are safe and immunogenic. In order for these vaccines to eradicate HBV a universal vaccination of neonates and/or children needs to be implemented. Major obstacles on the road to global hepat...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2001.032

    authors: Leroux-Roels G,Cao T,De Knibber A,Meuleman P,Roobrouck A,Farhoudi A,Vanlandschoot P,Desombere I

    更新日期:2001-07-01 00:00:00

  • Classification of medicines according to their influence on driving ability.

    abstract::Within the scope of an information campaign of the Belgian Institute for Road Safety an attempt was made to classify 179 medicinal drugs from 9 therapeutic groups, listed in the Belgian "Commented Repertory of Drugs--1997", according to their effect on driving performance. The categorisation was based on literature da...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:

    authors: Maes V,Grenez O,Charlier C,Smet H,Verstraete A,Wennig R

    更新日期:1999-01-01 00:00:00