Abstract:
:The arrival of new cephalosporins faces the clinician with an evergrowing confusion as to the drug of choice. The older agents (cephalexin, cephradine, cefadroxil and cefaclor) and the newer formulations cefatrizine and cefuroxime axetil are intensively used for treatment of mild and moderate infections. The oldest agents have a better pharmacokinetic profile but are less active against Gram-positives and Gram-negatives. Cefaclor, cefatrizine and cefuroxime axetil have improved in vitro activity against H. influenzae and/or against S. aureus and M. catarrhalis. However the mean free serum concentrations after proposed standard daily doses of cefaclor (3 x 250 mg/d), cefatrizine (2 x 500 mg/d) and cefuroxime-axetil (2 x 250 mg/d) are lower than those of the older cephalosporins. In comparison amoxicillin-clavulanate is equally efficacious, has a more reliable pharmacokinetic profile and is less expensive than cefaclor and cefuroxime axetil in a comparable dose (e.g. 3 x 500 mg/d).
journal_name
Acta Clin Belgjournal_title
Acta clinica Belgicaauthors
Verhaegen J,Verbist Ldoi
10.1080/17843286.1992.11718259keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
377-86issue
6eissn
1784-3286issn
2295-3337journal_volume
47pub_type
杂志文章,评审abstract:OBJECTIVE AND IMPORTANCE:Postprandial reactive hypoglycaemia (PRH) is a clinical syndrome characterized by the recurrence of symptomatic hypoglycaemia during postprandial periods. PRH remains a diagnostic challenge for clinicians, because of its atypical manifestations and low prevalence, especially in older persons. ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/2295333714Y.0000000026
更新日期:2014-08-01 00:00:00
abstract::We report about 2 cases of isolated mediastinal tuberculous lymphadenitis presenting without parenchymal infiltrates. Although rare, this mode of presentation reminds the clinician that tuberculosis has to be included in the differential diagnosis of mediastinal masses even in the absence of parenchymal lesion. Both c...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1998.11754153
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:The use of hypnosedatives (HSs) in the hospital and at home before admission was registered. Also, the incidence of HSs newly started in the hospital and the incidence of withdrawal in chronic users while in hospital was recorded. METHODS:The study population consisted of 517 consecutively admitted patients ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2003.58.4.003
更新日期:2003-07-01 00:00:00
abstract:INTRODUCTION:Hospital Acquired Infections (HAIs) are considered to be one of the most serious patient safety issues in healthcare today. It has been shown that HAIs contribute significantly not only to morbidity and mortality, but also to excessive costs for the health care system and for hospitalized patients. Since p...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.2143/ACB.3258
更新日期:2013-05-01 00:00:00
abstract::The toxic Paraphenylenediamine is characterized by infrared spectrophotometry and nuclear magnetic resonance spectroscopy, whereas, high performance liquid chromatography with a refractive index detector was used to determine its purity in the suspect samples using external standardisation. An analytical method for de...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2006.068
更新日期:2006-01-01 00:00:00
abstract::The frequency of neurologic involvement in sarcoidosis is about 5%. When the clinical picture presents with only neurological manifestations, as it did in our patient, the diagnosis at presentation is often difficult. Involvement of other tissues must therefore be actively searched. We describe a case of neurosarcoido...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1080/17843286.1992.11718250
更新日期:1992-01-01 00:00:00
abstract::We report the case of a 60-year-old man who presented with sudden visual loss, a history of postprandial abdominal pain, malabsorption, and skin lesions typical of systemic Degos' disease. Despite anti-aggregants and prednisone the patient's status did not improve. On the basis of the hypothetical dysimmune origin of ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2008.63.2.007
更新日期:2008-03-01 00:00:00
abstract::Objective: To present an overview of almost two decades of multi-faceted campaigning by the Belgian Antibiotic Policy Coordination Committee (BAPCOC) and partners, and its impact on public and prescribers' awareness, outpatient antibiotic use, its cost and antimicrobial resistance in Belgium.Methods: Awareness of both...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2020.1721135
更新日期:2020-02-05 00:00:00
abstract::Diabetes registries have documented that the lifetime risk of diabetes amounts to at least 10% in the western world. Moreover the prevalence of type 2 diabetes is increasing worldwide especially in developing countries. Furthermore there is a secular trend toward earlier clinical manifestation of both type 1 and type ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2004.001
更新日期:2004-01-01 00:00:00
abstract::We report on a severe allergic reaction during urethral catheterisation, initially erroneously attributed to natural rubber latex (NRL). However, the negative investigations for latex, the uneventful further applications of NRL, the positive skin test and basophil activation test for chlorhexidine strongly support dia...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2004.051
更新日期:2004-11-01 00:00:00
abstract::After notification of a case of fulminant hepatitis B virus (HBV) infection in a 83-year-old female resident of a nursing home to the Flemish Health Inspectorate, a seroepidemiological study and a retrospective cohort study were conducted among the 94 residents and 47 nursing staff to assess the extent of HBV transmis...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2005.012
更新日期:2005-03-01 00:00:00
abstract::A case of double neutrophilic population in a more or less symptomless patient is described. The diagnosis is made on one hand by the presence of 2 distinct neutrophil clusters on the PEROX display of the H* 1 hematological automate, on the other hand by cytochemical peroxidase staining which clearly confirms the exis...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1993.11718337
更新日期:1993-01-01 00:00:00
abstract::Background: Metastatic clear-cell renal cell carcinoma (m-ccRCC) patients with bone metastases (BM) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) have a poorer outcome compared to patients without BM. We aimed to investigate whether an increased incidence of VEGFR-TK...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2018.1551744
更新日期:2019-12-01 00:00:00
abstract::Central venous catheters are widely used in clinical practice. Air embolism is a rare, but potentially life threatening complication of central venous catheterisation. We describe a case of collapse and transient hemiplegia after removal of central venous catheter. This was accidentally performed with the patient in u...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2010.009
更新日期:2010-01-01 00:00:00
abstract::Thorax scan was performed for elucidation of a pulmonary problem in a Nigerian immigrant. The aspect of the vertebrae suggested sickle cell disease, of course without specification of the genotype. Routine hematological tests seemed compatible with an HbSC disease, showing typical laboratory features, namely a signifi...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2005.057
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:Recently, SOHO and CATIE's studies in the field of schizophrenic disorders asserted that molecules apparently showing the most side-effects are not only the most effective but also lead to the least changes in treatments. Can we generalise this assertion to other domains of pharmacological treatments, such a...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2008.043
更新日期:2008-07-01 00:00:00
abstract::The kidneys play a major role in the regulation of the salt balance and thereby regulate blood pressure. Salt sensitivity is acquired or genetically-induced and is noted in about 50% of patients with essential hypertension. This property leads to a high cardiovascular risk. In this situation, the benefit of salt restr...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2007.053
更新日期:2007-09-01 00:00:00
abstract::We describe a case of primary aldosteronism secondary to bilateral adrenal hyperplasia in three subsequent pregnancies. The disease was diagnosed soon after the first pregnancy, which ended in a miscarriage, and was treated pharmacologically with spironolactone. Because spironolactone is contraindicated in pregnancy, ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.2143/ACB.67.2.2062644
更新日期:2012-03-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected hematological malignancies. Its curative potential is based on two very different mechanisms, involving the conditioning regimen and the graft-versus-host reactions, respectively. The high-dose chemo-radiotherapy conditioni...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2003.58.1.005
更新日期:2003-01-01 00:00:00
abstract::The authors analyse the bacteriological data gathered by 100 successive tracheal Punctures and compare these results to those obtained by sputum cultures, which had either been collected by routine or when withdrawing the catheter for tracheal aspiration. This plain and not hazardous technique allows to draw the follo...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1971.11716773
更新日期:1971-01-01 00:00:00
abstract::Estrogen treatment in high doses is effective in reducing adult stature in constitutionally tall girls. In this study, growth data of 38 normal girls with a predicted final height beyond 178 cm, are reported. They were treated with ethinyloestradiol in a daily dose of 0.200 mg until the epiphyseal plates were practica...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Urinary schistosomiasis, caused by Schistosoma haematobium, is a prevalent parasitic infection in certain areas of Africa and the Middle East. Humans can be infected by cercariae when they are in contact with contaminated freshwater. The adult worms reside in the veins of the vesical and pelvis plexuses. The urinary b...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.2143/ACB.3261
更新日期:2013-05-01 00:00:00
abstract::Malakoplakia is a rare inflammatory disease involving most frequently the urinary tract. We present a case of bilateral renal malakoplakia, in which FDG-PET contributed to diagnosis. We made this diagnosis on the basis of clinical presentation, renal biopsy showing a mixed cellular infiltrate with granuloma formation ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2004.020
更新日期:2004-05-01 00:00:00
abstract::The diffuse infiltration by plasma cells in the liver is not uncommon in multiple myeloma (MM). However, a MM with hepatic mass is very unusual. We report a case of a 75-year-old male with hepatomegaly and a lesion occupying a voluminous space in the liver. A lambda light chain multiple myeloma was found in the check-...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.2143/ACB.67.5.2062696
更新日期:2012-09-01 00:00:00
abstract::'Lung cancer associated with cystic airspaces' is a rare radiological entity that is more frequently encountered on imaging studies and is gaining more attention since the widespread use of CT for lung cancer screening. Numerous aspects of this entity remain unraveled, including molecular profiling. The goal of this o...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2019.1680134
更新日期:2019-10-15 00:00:00
abstract::Primary sclerosing cholangitis (PSC) and idiopathic pulmonary fibrosis (IPF) were each separately described in association with a variety of chronic idiopathic inflammatory diseases such as retroperitoneal fibrosis, Sicca complex or Riedel's thyroiditis. We report a case which may be the first description of the assoc...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1989.11717982
更新日期:1989-01-01 00:00:00
abstract::Psoriasis affects about 2 to 3% of the caucasian population. It is a chronic inflammatory disease affecting predominantly the skin with the involvement of autoimmune mediated mechanisms. Typical pathogenic features include an increased renewal of epidermal keratinocytes, the enlargement of the germinating compartment,...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.2143/ACB.3387
更新日期:2013-11-01 00:00:00
abstract::VTE presents a significant clinical and economic burden on healthcare. Previous strategies (chemical and mechanical) were not full-proof when used in isolation. The advent of more recent treatments such as factor Xa inhibitors and direct thrombin inhibitors may help to provide more conclusive preventative management o...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2009.093
更新日期:2009-11-01 00:00:00
abstract::The National Institute for Insurance of Disease and Disablement (RIZIV/INAMI) in Belgium reimburses the costs of long term oxygen therapy (LTOT) by concentrators since 1984 and by liquid oxygen since 1988 for specific categories of patients supervised by approved medical centers. Since then we prescribed these therapi...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1995.11718439
更新日期:1995-01-01 00:00:00
abstract::We retrospectively studied 29 cases of S.pyogenes bacteremia, treated from September 1985 through September 1993, in order to define the clinical pattern, predisposing factors and the outcome of S.pyogenes bacteremia in our region. The number of infections, the clinical picture and mortality rate of S.pyogenes bactere...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1995.11718427
更新日期:1995-01-01 00:00:00