Bone metastases and age are associated with earlier dose reductions in metastatic clear-cell renal cell carcinoma patients treated with angiogenesis inhibitors.

Abstract:

:Background: Metastatic clear-cell renal cell carcinoma (m-ccRCC) patients with bone metastases (BM) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) have a poorer outcome compared to patients without BM. We aimed to investigate whether an increased incidence of VEGFR-TKI treatment interruptions and/or dose reductions in patients with BM could explain this difference in outcome. Patients and methods: Retrospective study on m-ccRCC patients treated in first-line with VEGFR-TKI. Analysis of the incidence of treatment interruptions and dose reductions and time-to-event analysis. Study of the correlation with the presence of BM at start of first-line VEGFR-TKIs. Results: Two-hundred-and-five patients were included. In patients with BM, median time-to-dose-reduction was significantly shorter (3 versus 5 cycles; p = 0.005) than in patients without BM. 63% of the total number of cycles was administered at reduced dose, compared to 41% in patients without BM. Age at start of VEGFR-TKI (≤ versus >70 years) was significantly associated with median time-to-dose-reduction (5 versus 3 cycles; p = 0.007). On multivariate analysis, the presence of BM (p = 0.004; HR 1.82, 95%CI 1.21-2.73) and age at start of VEGFR-TKIs (p = 0.017; HR 1.65, 95%CI 1.10-2.50) were independently associated with time-to-dose-reduction. Conclusion: In m-ccRCC patients treated with VEGFR-TKIs, dose reductions occurred earlier in patients with BM compared to patients without BM and in elderly patients.

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

Haaker L,De Meue E,Wildiers H,Verbiest A,Dumez H,Lerut E,Pans S,Albersen M,Beuselinck B

doi

10.1080/17843286.2018.1551744

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

414-423

issue

6

eissn

1784-3286

issn

2295-3337

journal_volume

74

pub_type

杂志文章
  • Successful infliximab therapy in a patient with comorbid spondyloarthritis, primary biliary cirrhosis and generalized morphea.

    abstract::The patient in this report was diagnosed simultaneously with primary biliary cirrhosis (PBC), spondyloarthritis, and generalized morphea and was started on infliximab therapy. In addition to an improvement in clinical symptoms with this therapy, an improvement was also observed in laboratory parameters such as cholest...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2017.1290567

    authors: Resorlu H,Kılıc S,Isık S,Gokmen F

    更新日期:2017-10-01 00:00:00

  • Evaluation of a new automated microscopy urine sediment analyser - sediMAX conTRUST®.

    abstract::This study evaluated the performance of the stand-alone sediMAX conTRUST (77Elektronika, Budapest, Hungary) analyser as an alternative to microscopic analysis of urine. The validation included a precision, carry-over, categorical correlation and diagnostic performance study with manual phase-contrast microscopy as ref...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2016.1249999

    authors: Bogaert L,Peeters B,Billen J

    更新日期:2017-04-01 00:00:00

  • Noosa, 2 years later... a critical analysis of recent literature.

    abstract:INTRODUCTION:Since the second World Congress on the Abdominal Compartment Syndrome (WCACS) in Noosa 2 years ago, interest and publications on intra-abdominal hypertension (IAH) and ACS have increased exponentially. This paper aimed to critically review recent publications and put this new data into the context of alrea...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:

    authors: Wauters J,Wilmer A

    更新日期:2007-01-01 00:00:00

  • Oral cephalosporins.

    abstract::The arrival of new cephalosporins faces the clinician with an evergrowing confusion as to the drug of choice. The older agents (cephalexin, cephradine, cefadroxil and cefaclor) and the newer formulations cefatrizine and cefuroxime axetil are intensively used for treatment of mild and moderate infections. The oldest ag...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1992.11718259

    authors: Verhaegen J,Verbist L

    更新日期:1992-01-01 00:00:00

  • Nivolumab and anti-HCV activity, a case report.

    abstract::Exhaustion of antigen-specific T-cells in order to escape immune destruction is frequently seen in chronic viral infection and different types of cancer. Blockade of overexpressed negative co-stimulatory pathways, a process known as immune checkpoint modulation, is a promising novel therapy that could improve the trea...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2020.1741897

    authors: Wuyts L,Janssens A,Vonghia L,Michielsen P,Raskin J,Driessen A,Van Hees S,Francque S,Vanwolleghem T

    更新日期:2020-03-17 00:00:00

  • Infective endocarditis.

    abstract::The diagnosis of infective endocarditis remains difficult. The complication rate is very high. Serious complications may occur and the overall mortality is still 20-25%. The sooner the treatment is started, the better the final result. Antibiotic therapy is essential but cardiac surgery is frequently necessary. Early ...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2008.085

    authors: Herregods MC,Hill E,Herijgers P,De Munter P,Vanderschueren S,Van Wijngaerden E,Peetermans WE

    更新日期:2008-11-01 00:00:00

  • Hypertension and the kidney.

    abstract::The kidney could be the cause of essential hypertension which can also cause renal disease. High blood pressure is also very common in chronic kidney disease, and is moreover a well-known risk factor for a faster progression of kidney failure. Hypertension and kidneys are thus closely linked. Hypertension must be aggr...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2007.002

    authors: Krzesinski JM,Cohen EP

    更新日期:2007-01-01 00:00:00

  • Severe pulmonary infections complicating nivolumab treatment for lung cancer: a report of two cases.

    abstract:BACKGROUND:Immunotherapy represents a recent milestone in the treatment of lung cancer, particularly with the rapidly expanding development of monoclonal antibodies targeting checkpoint inhibitors in the programmed cell death-1 (PD-1) pathway, such as nivolumab and pembrolizumab. Classical auto-immune side effects of t...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2019.1629078

    authors: Inthasot V,Bruyneel M,Muylle I,Ninane V

    更新日期:2020-08-01 00:00:00

  • Donor cell leukemia developing after hematopoietic stem cell transplantation for multiple myeloma.

    abstract::The development of secondary leukemia in donor cells after allogeneic stem cell transplantation is a rare event. We describe the occurrence of acute myeloid leukemia in donor cells 4 years after a stem cell transplantation for multiple myeloma. The multiple myeloma was relapsing at the time of the onset of acute myelo...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2006.016

    authors: Havelange V,Antoine-Poirel H,Saussoy P,Van Den Neste E,Ferrant A

    更新日期:2006-03-01 00:00:00

  • Disseminated histoplasmosis: case report and review of the literature.

    abstract::Case report We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest radiography revealed a 'miliary pattern'. Bone marrow aspiration pointed out yeast inclusions within macrophages. Giv...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.2017.1376454

    authors: Evrard S,Caprasse P,Gavage P,Vasbien M,Radermacher J,Hayette MP,Sacheli R,Van Esbroeck M,Cnops L,Firre E,Médart L,Moerman F,Minon JM

    更新日期:2018-10-01 00:00:00

  • A lady with NASH and choreoathetosis.

    abstract::We describe a case of acquired hepatocerebral degeneration (AHD) presenting with confusion and worsening memory problems since her discharge from the gastroenterology units. Cases of AHD are rare and are frequently confused with hepatic encephalopathy and Wilson's disease. There are no proven pharmacological therapies...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/2295333715Y.0000000027

    authors: Ghys C,Kong MF,Glibert G,Lasser L,Karmali R

    更新日期:2015-10-01 00:00:00

  • Classification of medicines according to their influence on driving ability.

    abstract::Within the scope of an information campaign of the Belgian Institute for Road Safety an attempt was made to classify 179 medicinal drugs from 9 therapeutic groups, listed in the Belgian "Commented Repertory of Drugs--1997", according to their effect on driving performance. The categorisation was based on literature da...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:

    authors: Maes V,Grenez O,Charlier C,Smet H,Verstraete A,Wennig R

    更新日期:1999-01-01 00:00:00

  • Cancer-related fatigue.

    abstract::Cancer-related fatigue (CRF) is the most commonly reported symptom in patients with cancer with a prevalence up to 100%. It has a significant negative impact on quality of life. An effective management of CRF could significantly reduce the disease burden associated with cancer and its treatment. Unfortunately, the und...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2010.65.6.002

    authors: De Waele S,Van Belle S

    更新日期:2010-11-01 00:00:00

  • Hospital-acquired infections in Belgian acute-care hospitals: financial burden of disease and potential cost savings.

    abstract:INTRODUCTION:Hospital Acquired Infections (HAIs) are considered to be one of the most serious patient safety issues in healthcare today. It has been shown that HAIs contribute significantly not only to morbidity and mortality, but also to excessive costs for the health care system and for hospitalized patients. Since p...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.3258

    authors: Trybou J,Spaepen E,Vermeulen B,Porrez L,Annemans L

    更新日期:2013-05-01 00:00:00

  • Primary sclerosing cholangitis and idiopathic pulmonary fibrosis: a case report.

    abstract::Primary sclerosing cholangitis (PSC) and idiopathic pulmonary fibrosis (IPF) were each separately described in association with a variety of chronic idiopathic inflammatory diseases such as retroperitoneal fibrosis, Sicca complex or Riedel's thyroiditis. We report a case which may be the first description of the assoc...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1989.11717982

    authors: Jonard P,Geubel A,Wallon J,Rahier J,Dive C,Meunier H

    更新日期:1989-01-01 00:00:00

  • [Growth inhibition using estrogens in constitutionally tall girls].

    abstract::Estrogen treatment in high doses is effective in reducing adult stature in constitutionally tall girls. In this study, growth data of 38 normal girls with a predicted final height beyond 178 cm, are reported. They were treated with ethinyloestradiol in a daily dose of 0.200 mg until the epiphyseal plates were practica...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:

    authors: Du Caju MV,Bleyaert S,Op De Beeck L

    更新日期:1993-01-01 00:00:00

  • Bartonella endocarditis mimicking adult Still's disease.

    abstract::We describe the case of a 39-year-old Caucasian woman who was admitted to the University Hospital of Antwerp with a clinical picture suggestive of adult Still's disease. Even though a transoesophageal echocardiography showed endocarditis of the aortic valve, blood cultures remained negative. Additional serological tes...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2008.030

    authors: De Clerck KF,Van Offel JF,Vlieghe E,Van Marck E,Stevens WJ

    更新日期:2008-05-01 00:00:00

  • A rare cause of severe recurrent abdominal pain.

    abstract::Recurrent abdominal pain may be enigmatic to solve. We report three cases, presenting after a protracted history of severe recurrent bouts of epigastric pain, impeding daily activities. In all cases, serology for strongyloidiasis stercoralis proved positive. In one case, stool examination was positive for larvae. Trea...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.2143/ACB.68.1.2062725

    authors: Isen C,Ivens C,Callens SF,Meeuwissen J,Vonck A,Koch A,Vogelaers D

    更新日期:2013-01-01 00:00:00

  • Type 1 (insulin-dependent) diabetes mellitus: an autoimmune, predictable and preventable disease? Lessons from national registries and new challenges to clinical biology.

    abstract::Type 1 (insulin-dependent) diabetes mellitus is a frequent chronic disease that affects children as well as adults. The disease keeps a life-long burden on patients, their environment and society. Although still incompletely understood, its pathogenesis becomes progressively unravelled. Autoimmune phenomena play an im...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.1993.11718293

    authors: Gorus FK,Anselmo J,Keymeulen B

    更新日期:1993-01-01 00:00:00

  • Rapid diagnosis of viral respiratory infections. Comparison between immunofluorescence on clinical samples and immunofluorescence on centrifuged cell cultures.

    abstract::We compared the technique of immunofluorescence on clinical samples (IFCS) and immunofluorescence on centrifuged cell cultures (IFCC) for the detection of respiratory viruses, using monoclonal antibodies. Four hundred fourty five nasopharyngeal aspirates were tested prospectively for RSV, influenza- (A and B), parainf...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1991.11718134

    authors: Pattyn SR,Provinciael D,Lambrechts R,Ceuppens P

    更新日期:1991-01-01 00:00:00

  • Durable response after VNCOP-B and rituximab in an elderly patient with high-grade B-cell lymphoma.

    abstract:OBJECTIVES AND METHODS: High-grade B-cell lymphoma, NOS (HGBL) have an aggressive clinical behavior and poor outcome using regimens currently employed for diffuse large B-cell lymphoma (DLBCL) such as rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Promising results have been reported wi...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.2017.1412888

    authors: Cencini E,Fabbri A,Schiattone L,Gentili F,Mazzei MA,Bocchia M

    更新日期:2018-12-01 00:00:00

  • [Study of a group of diabetic patients enrolled in the INAMI convention "Self-monitoring of blood glucose"].

    abstract::We have studied the clinical characteristics of 126 insulin-treated diabetic patients, mainly type I subjects, who regularly performed during 18 months home glucose monitoring. The numbers of strips used each month was of 60 +/- 33 (mean +/- lSD). During the study period, HbA1C levels decreased from 8.6 +/- 2.1 to 7.0...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1993.11718324

    authors: Buysschaert M,Lambert L,Donckier J,Jamart J

    更新日期:1993-01-01 00:00:00

  • HIV-associated multicentric Castleman disease: a report of 4 cases and review of the literature.

    abstract:BACKGROUND:Multicentric Castleman's disease (MCD) is a rare, non-clonal lymphoproliferative disorder characterized by constitutional symptoms, anaemia and generalised lymphadenopathy. Its incidence among the HIV-positive population seems to have increased during the past decades. AIM:The present study intends to compa...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.2143/ACB.66.1.2062510

    authors: Jonckheere S,Vandercam B,Theate I,Michaux L,Yombi JC

    更新日期:2011-01-01 00:00:00

  • Novel insights in the treatment of diabetic nephropathy.

    abstract::Diabetes is currently one of the leading causes of end-stage renal failure requiring renal replacement therapy in the Western World. About 15% to 20% of type 1 diabetic patients and 30% to 40% of type 2 diabetic patients will eventually develop end-stage renal failure. To prevent the development or progression of diab...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1179/acb.2007.043

    authors: Schrijvers BF,De Vriese AS

    更新日期:2007-09-01 00:00:00

  • How to treat a fulminant erysipelas and sepsis caused by Myroides odoratimimus: case report and literature review.

    abstract::We report a case of a 77-year old male who developed a fulminant erysipelas and sepsis, caused by Myroides odoratimimus. Selecting the optimal antibiotic therapy for the treatment of infections with M. odoratimimus is challenging due to limited clinical experience with this micro-organism and its reported multidrug-re...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/17843286.2016.1245173

    authors: Willems P,Muller J,Verhaegen J,Saegeman V,Desmet S

    更新日期:2017-10-01 00:00:00

  • Psoriasis: state of the art 2013.

    abstract::Psoriasis affects about 2 to 3% of the caucasian population. It is a chronic inflammatory disease affecting predominantly the skin with the involvement of autoimmune mediated mechanisms. Typical pathogenic features include an increased renewal of epidermal keratinocytes, the enlargement of the germinating compartment,...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.2143/ACB.3387

    authors: de la Brassinne M,Failla V,Nikkels A

    更新日期:2013-11-01 00:00:00

  • Usage criminel de substances psycho-actives : le problème de la durée de détection.

    abstract::On a regular basis, the media presents the potential risks of the use of psycho-active compounds, including misused pharmaceuticals (flunitrazepam, GHB) or drugs of abuse (cannabis, LSD, ecstasy). Ethanol is also frequently encountered. These drugs can be used for recreational purposes by addicts or can be observed af...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1179/acb.2002.072

    authors: Kintz P,Villain M,Cirimele V,Goullé J,Ludes B

    更新日期:2002-01-01 00:00:00

  • Thoracoscopic sympathicolysis for essential hyperhidrosis: immediate and one year follow-up results in 35 patients and review of the literature.

    abstract::Various treatments for essential hyperhidrosis are available. The aim of this study is to present our experience with a simplified thoracoscopic sympathicolysis technique in this disorder, and to confront our results with data in the literature, 35 consecutive patients (11 male, 24 female, age 12-44 years) with essent...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章,评审

    doi:10.1080/22953337.1996.11718517

    authors: Noppen M,Vincken W,Dhaese J,Herregodts P,D'haens J

    更新日期:1996-01-01 00:00:00

  • Recurrent pleuro-pericarditis due to gastrodiaphragmatic fistula.

    abstract::A 61-year-old woman presented with recurrent pleuro-pericarditis following Nissen fundoplication. A diagnosis of anterior gastrodiaphragmatic fistula was made. The suspected etiology of the fistula was local ischemia. This kind of fistula, although exceptional, should always be considered in the presence of unexplaine...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1990.11718077

    authors: Descamps OS,Donckier JE,Collard JM,Michel L,Trigaux JP,Melange M,Buysschaert M

    更新日期:1990-01-01 00:00:00

  • A massive, near-fatal cocaine intoxication in a body-stuffer. Case report and review of the literature.

    abstract::The last decade an increase has been seen in drug smuggling. Body-packing and body-stuffing are the terms used for intracorporeal concealment of illicit drugs (mainly cocaine and heroine, but sometimes also amphetamines and cannabinoids). These body-packets are especially prone to rupture. In order to avoid systemic c...

    journal_title:Acta clinica Belgica

    pub_type: 杂志文章

    doi:10.1080/17843286.1994.11718357

    authors: Malbrain ML,Neels H,Vissers K,Demedts P,Verbraeken H,Daelemans R,Wauters A

    更新日期:1994-01-01 00:00:00