Durable response after VNCOP-B and rituximab in an elderly patient with high-grade B-cell lymphoma.

Abstract:

OBJECTIVES AND METHODS: High-grade B-cell lymphoma, NOS (HGBL) have an aggressive clinical behavior and poor outcome using regimens currently employed for diffuse large B-cell lymphoma (DLBCL) such as rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Promising results have been reported with more intensive regimens but this strategy is not suitable for elderly or unfit patients. Rituximab in association with cyclophosphamide, mitoxantrone, vincristine, etoposide, bleomycin, and prednisone (R-VNCOP-B) demonstrated high efficacy and manageable toxicity as first-line treatment for elderly aggressive non-Hodgkin lymphoma patients. RESULTS AND CONCLUSION:In this case study, we report the rapid improvement, long-lasting complete remission, and mild toxicity of R-VNCOP-B regimen in an elderly, triple-expressor HGBL patient, with aggressive disease and poor-risk profile.

journal_name

Acta Clin Belg

journal_title

Acta clinica Belgica

authors

Cencini E,Fabbri A,Schiattone L,Gentili F,Mazzei MA,Bocchia M

doi

10.1080/17843286.2017.1412888

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

408-412

issue

6

eissn

1784-3286

issn

2295-3337

journal_volume

73

pub_type

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