Abstract:
:The purpose of this study was to characterize the clinical picture of macroprolactinemic patients and to further assess whether macroprolactinemia was part of an auto-immune syndrome. Eighty-two hyperprolactinemic (serum PRL > 1000 mU/l) patients were investigated and the PEG precipitation test identified 14 patients with macroprolactinemia (bb PRL). They were submitted to a hormonal and autoimmune screening and an IV TRH test. Bioactivity of their serum prolactin was evaluated, using an Nb2 assay. The biochemical nature of bb-PRL was investigated by immunoprecipitation with anti-IgG antibodies. Seventy-nine percent of the studied patients presented with infertility, amenorrhoea, galactorrhoea, mastodynia, gynaecomastia or erectile dysfunction. In most cases, however, these symptoms could be explained by the presence of other non hyperprolactinemia-related pathology. Despite the finding of in vitro biological activity in all macroprolactinemic sera tested, our results suggest a variable in vivo bioactivity of bb-PRL, probably related to a reduced capacity to cross vascular endothelium. In this study, we demonstrated that in 12 out of 13 samples (85%), bb-PRL consisted of PRL-IgG complexes. There was no clinical or laboratory evidence of auto-immunity.
journal_name
Acta Clin Belgjournal_title
Acta clinica Belgicaauthors
Theunissen C,De Schepper J,Schiettecatte J,Verdood P,Hooghe-Peeters EL,Velkeniers Bdoi
10.1179/acb.2005.034keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
190-7issue
4eissn
1784-3286issn
2295-3337journal_volume
60pub_type
杂志文章abstract::In Belgium, individual laboratory and treatment data of all HIV-infected patients seen in the 9 AIDS Reference Centres and 7 AIDS Reference Laboratories are collected prospectively since 2006. We present here an analysis of patients recorded in the cohort database between 1st of January 2006 and 31st of December 2008....
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.2143/ACB.67.5.2062686
更新日期:2012-09-01 00:00:00
abstract::A case of double neutrophilic population in a more or less symptomless patient is described. The diagnosis is made on one hand by the presence of 2 distinct neutrophil clusters on the PEROX display of the H* 1 hematological automate, on the other hand by cytochemical peroxidase staining which clearly confirms the exis...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1993.11718337
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Multicentric Castleman's disease (MCD) is a rare, non-clonal lymphoproliferative disorder characterized by constitutional symptoms, anaemia and generalised lymphadenopathy. Its incidence among the HIV-positive population seems to have increased during the past decades. AIM:The present study intends to compa...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.2143/ACB.66.1.2062510
更新日期:2011-01-01 00:00:00
abstract::Objective: To present an overview of almost two decades of multi-faceted campaigning by the Belgian Antibiotic Policy Coordination Committee (BAPCOC) and partners, and its impact on public and prescribers' awareness, outpatient antibiotic use, its cost and antimicrobial resistance in Belgium.Methods: Awareness of both...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2020.1721135
更新日期:2020-02-05 00:00:00
abstract::Acute severe pancreatitis is an aggressive disease with a mortality rate of up to 30 percent. In recent years therapy has shifted away from early surgery to intensive medical care. This article focuses on several issues of the management of acute severe pancreatitis emphasising evidence from recent clinical trials and...
journal_title:Acta clinica Belgica
pub_type: 社论,评审
doi:10.1179/acb.2001.023
更新日期:2001-05-01 00:00:00
abstract::Infection with hepatitis B virus has become a vaccine-preventable disease. The recombinant hepatitis B vaccines available today are safe and immunogenic. In order for these vaccines to eradicate HBV a universal vaccination of neonates and/or children needs to be implemented. Major obstacles on the road to global hepat...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2001.032
更新日期:2001-07-01 00:00:00
abstract::We performed a systematic survey of original papers published in The Lancet throughout the years 1945, 1946, 1970 and 1995. The Lancet was chosen due to a conservative layout through these years, and the year 1946 added to the analysis to ponder for any war-induced bias. The general layout and structure of the journal...
journal_title:Acta clinica Belgica
pub_type: 历史文章,杂志文章
doi:10.1179/acb.2004.011
更新日期:2004-03-01 00:00:00
abstract::There is a need for legal control of sensitivity discs. False results are obtained by the use of discs containing an antibiotic and an unlabelled antimicrobial drug. Results of sensitivity tests (performed by the disc agar diffusion method) using Levocyclin8 discs furnished by the manufacturers were highly improbable....
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1976.11717057
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVES:A decreasing incidence of tuberculosis (TB) among HIV patients has been documented in high-income settings and screening for tuberculosis is not systematically performed in many clinics (such as ours). Our objectives are to evaluate whether a same decline of incidence was seen in our Belgian tertiary center ...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2016.1237696
更新日期:2017-08-01 00:00:00
abstract::We reported the case of a patient with stage IV Hodgkin's disease (involving the nodes and Liver) presenting with paraneoplastic fever and who subsequently developed hypothermia during chemotherapy administration. We also reviewed the 12 other cases of hypothermia in Hodgkin's disease reported in the literature and di...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2006.042
更新日期:2006-09-01 00:00:00
abstract::Estrogen treatment in high doses is effective in reducing adult stature in constitutionally tall girls. In this study, growth data of 38 normal girls with a predicted final height beyond 178 cm, are reported. They were treated with ethinyloestradiol in a daily dose of 0.200 mg until the epiphyseal plates were practica...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Temocillin, a methoxy-derivative of the broad-spectrum penicillin, ticarcillin, has been introduced into clinical practice in Belgium in 1988. Since then, not many surveys of its in vitro activity have been published. This study addresses this issue in a prospective collection of 300 consecutive Gram-negative isolates...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2001.053
更新日期:2001-11-01 00:00:00
abstract::We report the findings in 21 Belgian patients (12 males and 9 females, median age 61 years) with LGLPD. Symptoms at presentation included infection (n = 9), weight loss (n = 5), asthenia (n = 9), pruritus (n = 2) and arthralgia (n = 7). Four patients were asymptomatic. The main clinical findings were hepatomegaly (n =...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1080/17843286.1992.11718206
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To assess the diagnostic performance of the CAGE and AUDIT (Alcohol Use Disorder Identification Test) and its derivatives, and laboratory tests for screening alcohol abuse or dependence in a male medical hospital population. DESIGN:A diagnostic cross-sectional prevalence study. SETTING:Three general hospita...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2002.048
更新日期:2002-09-01 00:00:00
abstract::Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major active metabolite, hydroxy-itraconazole) in serum can be usef...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/0001551213Z.00000000018
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Several studies have shown that pneumococcal vaccination of older persons would be cost-effective in preventing pneumococcal pneumonia, but evidence of clinical protection for this condition is uncertain. Given much better evidence of vaccination effectiveness against invasive disease, studies showing that v...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::Diabetes is currently one of the leading causes of end-stage renal failure requiring renal replacement therapy in the Western World. About 15% to 20% of type 1 diabetic patients and 30% to 40% of type 2 diabetic patients will eventually develop end-stage renal failure. To prevent the development or progression of diab...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2007.043
更新日期:2007-09-01 00:00:00
abstract::The kidneys play a major role in the regulation of the salt balance and thereby regulate blood pressure. Salt sensitivity is acquired or genetically-induced and is noted in about 50% of patients with essential hypertension. This property leads to a high cardiovascular risk. In this situation, the benefit of salt restr...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1179/acb.2007.053
更新日期:2007-09-01 00:00:00
abstract::Significant visceral edema associated with massive fluid resuscitation, paralytic ileus and formation of pancreatic ascites in patients with severe acute pancreatitis (SAP) can lead to abdominal compartment syndrome (ACS) that can contribute to the early development of multiple organ dysfunction syndrome (MODS), espec...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::25 hospitalized patients, suffering from acute bronchopulmonary affections, received every 24 hours, one I.M. injection of 750 mg of tetracycline laurylsulfate (equivalent to 500 mg of tetracycline HCl). Positive clinical results were obtained in all cases. All isolated micro-organisms, sensitive in vitro to tetracycl...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1972.11716815
更新日期:1972-01-01 00:00:00
abstract::Introduction: Vitamin K plays an important role in blood coagulation. Diet is the main source of vitamin K and body stores are depleted in days, hence deficiency is common in malnourished older people. A high proportion of people who sustain a hip fracture are already malnourished, compounded by fasting for surgery wh...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2018.1564174
更新日期:2020-04-01 00:00:00
abstract::A 61-year-old woman presented with recurrent pleuro-pericarditis following Nissen fundoplication. A diagnosis of anterior gastrodiaphragmatic fistula was made. The suspected etiology of the fistula was local ischemia. This kind of fistula, although exceptional, should always be considered in the presence of unexplaine...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.1990.11718077
更新日期:1990-01-01 00:00:00
abstract::The frequency of neurologic involvement in sarcoidosis is about 5%. When the clinical picture presents with only neurological manifestations, as it did in our patient, the diagnosis at presentation is often difficult. Involvement of other tissues must therefore be actively searched. We describe a case of neurosarcoido...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1080/17843286.1992.11718250
更新日期:1992-01-01 00:00:00
abstract::We report a case of aneurysm of the abdominal aorta with spontaneous rupture in a 64-year-old man with emphysema and chronic alcoholism. Campylobacter fetus subspecies fetus was repeatedly recovered from the blood and from specimens of the excised aneurysm. The patient died in spite of early diagnosis, intravenous ery...
journal_title:Acta clinica Belgica
pub_type: 杂志文章,评审
doi:10.1080/17843286.1989.11717999
更新日期:1989-01-01 00:00:00
abstract::After notification of a case of fulminant hepatitis B virus (HBV) infection in a 83-year-old female resident of a nursing home to the Flemish Health Inspectorate, a seroepidemiological study and a retrospective cohort study were conducted among the 94 residents and 47 nursing staff to assess the extent of HBV transmis...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2005.012
更新日期:2005-03-01 00:00:00
abstract::Erysipelothrix rhusiopathiae is a rare cause of endocarditis. Most cases were observed in people working with animals. We report a case in a 45-year old man without any exposure to animals. He was admitted to our hospital because of dyspnoea. Blood cultures were drawn following fever on day 8 of hospitalisation. Erysi...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2003.58.6.006
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:The comprehensive geriatric assessment (CGA) can detect geriatric problems and potentially improve survival, physical, and cognitive state of patients, as well as increase an older person's chances of staying at home longer. In older people, the number and severity of comorbidity increase with age and are an...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1080/17843286.2016.1153816
更新日期:2016-08-01 00:00:00
abstract::Calciphylaxis, or calcific uremic arteriolopathy (CUA) is a rare but well described entity in patients with endstage renal disease (ESRD) and/or hyperparathyroidism. CUA is characterized by systemic acute calcification of the small and intermediate dermal vasculature that can lead to epidermal ischemia, ulceration, an...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.2143/ACB.2863
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:This study aims to evaluate the clinical outcome of fibrinolytic treatment of prosthetic valve thrombosis (PVT) with 'streptokinase' as a first line treatment for these cases. METHODS:The study group was 20 consecutive patients (10 females) diagnosed with PVT. The protocol for streptokinase administration w...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/2295333714Y.0000000107
更新日期:2015-06-01 00:00:00
abstract::Thorax scan was performed for elucidation of a pulmonary problem in a Nigerian immigrant. The aspect of the vertebrae suggested sickle cell disease, of course without specification of the genotype. Routine hematological tests seemed compatible with an HbSC disease, showing typical laboratory features, namely a signifi...
journal_title:Acta clinica Belgica
pub_type: 杂志文章
doi:10.1179/acb.2005.057
更新日期:2005-11-01 00:00:00