Abstract:
:The actin cytoskeleton is constantly assembling and disassembling. Cells harness the energy of these turnover dynamics to drive cell motility and organize cytoplasm. Although much is known about how cells control actin polymerization, we do not understand how actin filaments depolymerize inside cells. I briefly describe how the combination of imaging actin filament dynamics in cells and using in vitro biochemistry progressively altered our views of actin depolymerization. I describe why I do not think that the prevailing model of actin filament turnover--cofilin-mediated actin filament severing--can account for actin filament disassembly detected in cells. Finally, I speculate that cells might be able to tune the mechanism of actin depolymerization to meet physiological demands and selectively control the stabilities of different actin arrays.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Brieher Wdoi
10.1091/mbc.E12-09-0694subject
Has Abstractpub_date
2013-08-01 00:00:00pages
2299-302issue
15eissn
1059-1524issn
1939-4586pii
24/15/2299journal_volume
24pub_type
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