Dependence of optical attenuation coefficient and mechanical tension of irradiated human cartilage measured by optical coherence tomography.

Abstract:

:As banked human tissues are not widely available, the development of new non-destructive and contactless techniques to evaluate the quality of allografts before distribution for transplantation is very important. Also, tissues will be processed accordingly to standard procedures and to minimize disease transmission most tissue banks will include a decontamination or sterilization step such as ionizing radiation. In this work, we present a new method to evaluate the internal structure of frozen or glycerol processed human cartilages, submitted to various dosis of irradiation, using the total optical attenuation coefficient retrieved from optical coherence tomography (OCT) images. Our results show a close relationship between tensile properties and the total optical attenuation coefficient of cartilages. Therefore, OCT associated with the total optical attenuation coefficient open a new window to evaluate quantitatively biological changes in processed tissues.

journal_name

Cell Tissue Bank

journal_title

Cell and tissue banking

authors

Martinho AC Jr,Freitas AZ,Raele MP,Santin SP,Soares FA,Herson MR,Mathor MB

doi

10.1007/s10561-013-9389-6

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

337-43

issue

3

eissn

1389-9333

issn

1573-6814

journal_volume

15

pub_type

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