Lgr4 in ocular development and glaucoma.

Abstract:

:The leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4, also called GPR48) plays a key role in multiple developmental processes, and mice lacking Lgr4 display anterior segment dysgenesis leading to early-onset glaucomatous retinal ganglion cell loss as well as defective eyelid formation. This paper will review Lgr4 signaling and its regulation of the Axenfeld-Rieger syndrome gene Pitx2, a crucial developmental transcription factor. In addition, Wnt signaling plays an important role in eye development, with Norrin functioning to activate the Wnt receptor Frizzled 4 required for proper retinal vascularization. Recent discoveries identifying Lgr4 as a receptor for Norrin highlight the potential for Lgr4 function in retinal vascularization. Finally, several unanswered questions impeding a full understanding of Lgr4 in glaucoma are considered as avenues for further research.

journal_name

J Ophthalmol

journal_title

Journal of ophthalmology

authors

Siwko S,Lai L,Weng J,Liu M

doi

10.1155/2013/987494

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

987494

eissn

2090-004X

issn

2090-0058

journal_volume

2013

pub_type

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