Abstract:
Purpose:To evaluate the clinical classification and characteristics of hereditary optic neuropathy patients in a single center in China. Method:Retrospective case study. Patients diagnosed with hereditary optic neuropathy between January 2014 and December 2015 in the neuro-ophthalmology division in Shanghai Eye and ENT Hospital of Fudan University were recruited. Clinical features as well as visual field, brain/orbital MRI, and spectrum domain optical coherence tomography (SD-OCT) were analyzed. Results:Eighty-two patients diagnosed by gene test were evaluated, including 66 males and 16 females. The mean age of the patients was 19.4 years (range, 5-46 years). A total of 158 eyes were analyzed, including 6 unilateral, 61 bilateral, and 15 sequential. The median duration of the disease was 0.5 year (range, 0.1-20 years). Genetic test identified 68 patients with Leber hereditary optic neuropathy, 9 with dominant optic neuropathy, and 2 with a Wolfram gene mutation. There was also one case of hereditary spastic paraplegia, spinocerebellar ataxia, and polymicrogyria with optic nerve atrophy, respectively. Conclusion:Leber hereditary optic neuropathy is the most common detected type of hereditary optic neuropathy in Shanghai, China. The detection of other autosomal mutations in hereditary optic neuropathy is limited by the currently available technique.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Gan D,Li M,Wu J,Sun X,Tian Gdoi
10.1155/2017/6186052subject
Has Abstractpub_date
2017-01-01 00:00:00pages
6186052eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
杂志文章abstract:Purpose:To evaluate the efficacy and safety of the simultaneous use of short-term perfluoro-n-octane (PFO) with perfluoropropane (C3F8) gas to achieve retinal reattachment in eyes with rhegmatogenous retinal detachment (RRD) with proliferative vitreoretinopathy (PVR) grade C and multiple retinal breaks including inferi...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/6938627
更新日期:2020-10-07 00:00:00
abstract:Aims:To determine the accuracy and repeatability of new software to automatically quantify GA areas associated to age-related macular degeneration (AMD) by swept-source optical coherence tomography (SS-OCT). Settings and Design. Tertiary referral hospital in Spain. Cross-sectional and noninterventional. Methods and Mat...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/8204641
更新日期:2020-08-05 00:00:00
abstract:Purpose:To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27- AAU in the population of Slovenian patients. Methods:Retrospective study of hospitalized patients with AAU in the last 39 mo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/6079146
更新日期:2020-09-19 00:00:00
abstract:Objective:To determine whether accommodation induced by reading alters intraocular pressure (IOP) in healthy, young, emmetropic adults and to document the duration and magnitude of this effect. Design:Cross-sectional study. Participants. Fifteen healthy, emmetropic young adults. Methods:Subjects performed 20 minutes ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/1352434
更新日期:2020-01-28 00:00:00
abstract:Purpose:To investigate whether the risk of subsequent stroke, ischemic stroke, hemorrhagic stroke, and all-cause mortality is increased among retinal vein occlusion (RVO) patients compared to non-RVO patients. Methods:From the entire population of the Taiwan National Health Insurance Research Database (NHIRD) from 200...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/8629429
更新日期:2018-09-09 00:00:00
abstract:Purpose:To compare the efficacy of passive drainage (PD) and repeated fluid-air (FA) exchange for removing emulsified silicone oil (SO) droplets. Methods:Twenty rhegmatogenous retinal detachment (RRD) patients who underwent primary pars plana vitrectomy (PPV) with SO tamponade were randomly and evenly divided into two...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/8184607
更新日期:2020-07-04 00:00:00
abstract:AIM:To discuss the clinical characteristics of immune-related dry eye. METHODS:Simple dry eye (SDE) group: we selected 224 patients of simple dry eye with no systemic lesions. Immune-related dry eye (IRDE) group: we selected 207 patients of dry eye complicated with immune system diseases, including 70 cases of Sjögren...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/8532397
更新日期:2017-01-01 00:00:00
abstract::Individualized treatment regimens may reduce patient burden with satisfactory patient outcomes in neovascular age-related macular degeneration. Intravitreal anti-VEGF drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical t...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2015/412903
更新日期:2015-01-01 00:00:00
abstract::Purpose. To examine the clinical implications of change in choroidal neovascularization (CNV) size on indocyanine green (ICG) angiography in subjects with idiopathic CNV undergoing bevacizumab therapy. Methods. The charts of subjects with an idiopathic CNV treated by a modified PRN regimen with intravitreal bevacizuma...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/642624
更新日期:2015-01-01 00:00:00
abstract::Congenital cataract is the most common cause of the visual disability and blindness in childhood. This study aimed to identify gene mutations responsible for autosomal dominant congenital cataract (ADCC) in a Chinese family using next-generation sequencing technology. This family included eight unaffected and five aff...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/4353957
更新日期:2016-01-01 00:00:00
abstract::Purpose. To determine the efficacy of povidone-iodine (P-I) prophylaxis for ophthalmia neonatorum (ON) in Angola and to document maternal prevalence and mother-to-child transmission rates. Methods. Endocervical samples from mothers (n = 317) and newborn conjunctival smears (n = 245) were analysed by multiplex polymera...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/326526
更新日期:2015-01-01 00:00:00
abstract::The new type implantable Collamer lens with a central hole (V4c-ICL) is widely used to treat myopia. However, halos occur in some patients after surgery. The aim is to evaluate the effect of V4c-ICL implantation on vision-related daily activities. This retrospective study included 42 patients. Uncorrected visual acuit...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5717932
更新日期:2016-01-01 00:00:00
abstract:Purpose:To evaluate parent knowledge of screening and genetic testing for retinoblastoma and its potential correlation with demographics, clinical features, and socioeconomical factors. Methods:It was a cross-sectional study conducted at the ocular oncology unit of a tertiary ophthalmic center in Southern China. A fac...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/3839792
更新日期:2020-04-08 00:00:00
abstract::Purpose. To evaluate the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio(PLR) value in the development of branch retinal vein occlusion (BRVO)patients. METHODS:81 patients with BRVO and 81 age and sex-matched subjects were recruited as the control group. The BRVO diagnosis was confirmed under comp...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/6043612
更新日期:2019-10-31 00:00:00
abstract::Purpose. To assess the different check sizes of pattern visual evoked potential (PVEP) in diabetic patients without retinopathy according to HbA1c levels and diabetes duration. Methods. Fifty-eight eligible patients with type 2 diabetes mellitus and 26 age- and sex-matched healthy controls were included in the study. ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/8597629
更新日期:2017-01-01 00:00:00
abstract::Aim. To investigate the utility of fundus autofluorescence (FAF) and optical coherence tomography (OCT) in the evaluation of cystoid macular edema (CME) following cataract surgery. Materials and Methods. Forty eyes of 29 patients undergone phacoemulsification, with posterior chamber intraocular lens implantation surge...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/376013
更新日期:2013-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evalua...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2013/895147
更新日期:2013-01-01 00:00:00
abstract:Purpose:To describe a modified technique of white line advancement posterior ptosis surgery and to report the success rate of the procedure. Methods:A retrospective case series of 60 patients who presented with ptosis with good levator function. The success rate was defined as an MRD1 of greater than or equal to 3.5 m...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/9021848
更新日期:2020-07-15 00:00:00
abstract::Purpose. To assess the morphology of idiopathic choroidal neovascularization (ICNV) by optical coherence tomography angiography (OCTA) and determine the therapeutic effects of intravitreal antivascular endothelial growth factor (anti-VEGF). Method. Patients with naive ICNV were assessed by spectral domain optical cohe...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5608250
更新日期:2016-01-01 00:00:00
abstract:Purpose:Bilateral choroidal ganglioneuroma is extremely rare, and no cases have been described in the literature. Multimodal images are crucial for its diagnosis. Here, we evaluated multimodal images in the early stage of choroidal ganglioneuroma. Methods:A 6-year-old boy was recruited who had experienced gradually pr...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/6231269
更新日期:2020-05-11 00:00:00
abstract:Purpose:To present a new method of measuring ocular axial dimensions, termed OCT biometry (B-OCT). Design:Observational cross-sectional study and evaluation of new diagnostic technology. Methods:B-OCT was implemented in the spectral domain OCT device for posterior and anterior segment imaging (REVO NX, Optopol Techno...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9192456
更新日期:2019-08-14 00:00:00
abstract::Aim. To examine subscale and total scores of NEI-VFQ questionnaire of type 2 diabetes patients at different diabetic retinopathy (DRP) stages. Methods. A total number of 201 patients have been included. Prior to ophthalmological examination all patients participated in the NEI-VFQ questionnaire. The patients were divi...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1549318
更新日期:2016-01-01 00:00:00
abstract:Purpose:To evaluate the effect of corneal cap thickness on visual acuity and corneal biomechanics in small incision lenticule extraction (SMILE) for the treatment of myopia. Methods:Forty eyes of 20 patients undergoing SMILE for the treatment of myopia were enrolled in this prospective controlled study. The patients w...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6040873
更新日期:2018-06-28 00:00:00
abstract:Purpose:The purpose of this meta-analysis was to assess the percent reduction in the intraocular pressure (IOP) after argon laser peripheral iridoplasty (ALPI) and systemic medical therapy in patients with acute primary angle closure (APAC). Methods:We searched a number of electronic databases, including MEDLINE, EMBA...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/7697416
更新日期:2019-05-02 00:00:00
abstract::Purpose. To determine the efficacy of 23-gauge pars plana vitrectomy (PPV) for symptomatic posterior vitreous detachment (PVD) on visual acuity (VA) and quality after multifocal intraocular lenses (IOLs). Methods. In this prospective case series, patients who developed symptomatic PVD and were not satisfied with visua...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/156910
更新日期:2015-01-01 00:00:00
abstract:Purpose:To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naïve and treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). Methods:Consecutive pati...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/3751702
更新日期:2018-02-04 00:00:00
abstract::Macular pseudoholes (MPHs) and lamellar macular holes (LMHs) have been recently defined according to spectral domain optical coherence tomography (SD-OCT) criteria. A major feature for differentiating an MPH from an LMH remains the loss of foveal tissue. The anatomy of the foveola is peculiar with the macular pigment ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2019/4948212
更新日期:2019-02-10 00:00:00
abstract:Purpose:To identify the clinical characteristics and risk factors for secondary choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC). Methods:In this retrospective study, we included a total of 108 eyes in 106 CSC patients. Group A was defined as patients initially diagnosed with CSC who develo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/7217906
更新日期:2020-02-07 00:00:00
abstract::Current intraocular pressure (IOP) measurement using air puff could be erroneous without applying proper corrections. Although noncontact tonometry is not considered to be accurate, it is still popularly used by eye clinics. It is thus necessary to extract the correct information from their results. This study propose...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/5410143
更新日期:2017-01-01 00:00:00
abstract:Background:Bardet-Biedl syndrome (BBS) is a rare multisystem developmental disorder. In this study, we report the genetic causes and clinical manifestations in two Chinese families with BBS. Materials and Methods:Two families were recruited in this study. Family A was a four-generation family with four affected and 15...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2021/6751857
更新日期:2021-01-06 00:00:00