Mutations in the IMD pathway and mustard counter Vibrio cholerae suppression of intestinal stem cell division in Drosophila.

abstract：:DNA supercoiling (DS) is essential for life because it controls critical processes, including transcription, replication, and recombination. Current methods to measure DNA supercoiling in vivo are laborious and unable to examine single cells. Here, we report a method for high-throughput measurement of bacterial DNA su...

journal_title：mBio

authors： Duprey A,Groisman EA

更新日期：2020-07-28 00:00:00

abstract：:Hepatitis E virus (HEV), a single-strand positive-sense RNA virus, is an understudied but important human pathogen. The virus can establish infection at a number of host tissues, including the small intestine and liver, causing acute and chronic hepatitis E as well as certain neurological disorders. The retinoic acid-...

journal_title：mBio

authors： Sooryanarain H,Heffron CL,Meng XJ

更新日期：2020-01-14 00:00:00

abstract：:The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use cobamides, the vitamin B12 family of cofactors with struct...

journal_title：mBio

authors： Mok KC,Sokolovskaya OM,Nicolas AM,Hallberg ZF,Deutschbauer A,Carlson HK,Taga ME

更新日期：2020-12-08 00:00:00

abstract：:Avian influenza viruses (AIVs) must acquire mammalian-adaptive mutations before they can efficiently replicate in and transmit among humans. The PB2 E627K mutation is known to play a prominent role in the mammalian adaptation of AIVs. The H7N9 AIVs that emerged in 2013 in China easily acquired the PB2 E627K mutation u...

journal_title：mBio

authors： Liang L,Jiang L,Li J,Zhao Q,Wang J,He X,Huang S,Wang Q,Zhao Y,Wang G,Sun N,Deng G,Shi J,Tian G,Zeng X,Jiang Y,Liu L,Liu J,Chen P,Bu Z,Kawaoka Y,Chen H,Li C

更新日期：2019-06-18 00:00:00

abstract：:Protein ubiquitylation regulates not only endocellular trafficking and proteasomal degradation but also the catalytic activity of enzymes. In Saccharomyces cerevisiae, we analyzed the composition of the ubiquitylated proteomes in strains lacking acetyltransferase Gcn5p, Ub-protease Ubp8p, or both to understand their i...

journal_title：mBio

authors： De Palma A,Fanelli G,Cretella E,De Luca V,Palladino RA,Panzeri V,Roffia V,Saliola M,Mauri P,Filetici P

更新日期：2020-08-11 00:00:00

abstract：UNLABELLED:Recent studies strongly suggest that the gene expression sustaining both normal and pathogenic bacterial growth is governed by the structural dynamics of the chromosome. However, the mechanistic device coordinating the chromosomal configuration with selective expression of the adaptive traits remains largely...

journal_title：mBio

authors： Jiang X,Sobetzko P,Nasser W,Reverchon S,Muskhelishvili G

更新日期：2015-04-28 00:00:00

abstract：:Despite their exceptional potencies, the broad tropism of most commonly used lentivirus (LV) vectors limits their use for targeted gene delivery in vivo We hypothesized that we could improve the specificity of LV targeting by coupling (i) reduction of their binding to off-target cells with (ii) redirection of the vect...

journal_title：mBio

authors： Parker CL,Jacobs TM,Huckaby JT,Harit D,Lai SK

更新日期：2020-01-21 00:00:00

abstract：UNLABELLED:Pneumococcal pili have been shown to influence pneumococcal colonization, disease development, and the inflammatory response in mice. The role of the pilus-associated RrgA adhesin in pneumococcal interactions with murine and human macrophages was investigated. Expression of pili with RrgA enhanced the uptake...

journal_title：mBio

authors： Orrskog S,Rounioja S,Spadafina T,Gallotta M,Norman M,Hentrich K,Fälker S,Ygberg-Eriksson S,Hasenberg M,Johansson B,Uotila LM,Gahmberg CG,Barocchi M,Gunzer M,Normark S,Henriques-Normark B

更新日期：2012-12-26 00:00:00

abstract：UNLABELLED:Anti-tumor necrosis factor alpha (anti-TNF-α) therapies have been increasingly used to treat inflammatory diseases and are associated with increased risk of invasive fungal infections, including Cryptococcus neoformans infection. Using a mouse model of cryptococcal infection, we investigated the mechanism by...

journal_title：mBio

authors： Xu J,Eastman AJ,Flaczyk A,Neal LM,Zhao G,Carolan J,Malachowski AN,Stolberg VR,Yosri M,Chensue SW,Curtis JL,Osterholzer JJ,Olszewski MA

更新日期：2016-07-12 00:00:00

abstract：:The yeast Yarrowia lipolytica is a potent accumulator of lipids, and lipogenesis in this organism can be influenced by a variety of factors, such as genetics and environmental conditions. Using a multifactorial study, we elucidated the effects of both genetic and environmental factors on regulation of lipogenesis in Y...

journal_title：mBio

authors： Kerkhoven EJ,Kim YM,Wei S,Nicora CD,Fillmore TL,Purvine SO,Webb-Robertson BJ,Smith RD,Baker SE,Metz TO,Nielsen J

更新日期：2017-06-20 00:00:00

abstract：:The ability to withstand UV damage shapes the ecology of microbes. While mechanisms of UV tolerance were extensively investigated in microorganisms regularly exposed to the sun, far less is known about UV repair of soilborne microorganisms. Fusarium oxysporum is a soilborne fungal plant pathogen that is resistant to U...

journal_title：mBio

authors： Milo-Cochavi S,Adar S,Covo S

更新日期：2019-12-03 00:00:00

abstract：:In Escherichia coli, FtsEX coordinates peptidoglycan (PG) synthesis and hydrolysis at the septum. It acts on FtsA in the cytoplasm to promote recruitment of septal PG synthetases and recruits EnvC, an activator of septal PG hydrolases, in the periplasm. Following recruitment, ATP hydrolysis by FtsEX is thought to regu...

journal_title：mBio

authors： Du S,Pichoff S,Lutkenhaus J

更新日期：2020-07-07 00:00:00

abstract：:Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via nitric oxide synthase (NOS) activity, despite its apparent cytotoxicity. Here, we reveal a conserved role for bacter...

journal_title：mBio

authors： Chaudhari SS,Kim M,Lei S,Razvi F,Alqarzaee AA,Hutfless EH,Powers R,Zimmerman MC,Fey PD,Thomas VC

更新日期：2017-08-01 00:00:00

abstract：:Ocean viruses are ubiquitous and abundant and play important roles in global biogeochemical cycles by means of their mortality, horizontal gene transfer, and manipulation of host metabolism. However, the obstacles involved in linking viruses to their hosts in a high-throughput manner bottlenecks our ability to underst...

journal_title：mBio

authors： Deng L,Gregory A,Yilmaz S,Poulos BT,Hugenholtz P,Sullivan MB

更新日期：2012-10-30 00:00:00

abstract：:The blast fungus initiates infection using a heavily melanized, dome-shaped infection structure known as the appressorium, which forcibly ruptures the cuticle to enter the rice leaf tissue. How this process takes place remains not fully understood. Here, we used untargeted metabolomics analyses to profile the metabolo...

journal_title：mBio

authors： Liu XH,Liang S,Wei YY,Zhu XM,Li L,Liu PP,Zheng QX,Zhou HN,Zhang Y,Mao LJ,Fernandes CM,Del Poeta M,Naqvi NI,Lin FC

更新日期：2019-08-20 00:00:00

abstract：UNLABELLED:The urinary tract is one of the most frequent sites of bacterial infection in humans. Uropathogenic Escherichia coli (UPEC) strains are the leading cause of urinary tract infections (UTIs) and are responsible for greater than 80% of uncomplicated cases in adults. Infection of the urinary tract occurs in an a...

journal_title：mBio

authors： Walters MS,Lane MC,Vigil PD,Smith SN,Walk ST,Mobley HL

更新日期：2012-02-07 00:00:00

abstract：UNLABELLED:Many filamentous cyanobacteria produce specialized nitrogen-fixing cells called heterocysts, which are located at semiregular intervals along the filament with about 10 to 20 photosynthetic vegetative cells in between. Nitrogen fixation in these complex multicellular bacteria depends on metabolite exchange b...

journal_title：mBio

authors： Nürnberg DJ,Mariscal V,Bornikoel J,Nieves-Morión M,Krauß N,Herrero A,Maldener I,Flores E,Mullineaux CW

更新日期：2015-03-17 00:00:00

abstract：:A simple method for filtering water to reduce the incidence of cholera was tested in a field trial in Matlab, Bangladesh, and proved effective. A follow-up study was conducted 5 years later to determine whether the filtration method continued to be employed by villagers and its impact on the incidence of cholera. A to...

journal_title：mBio

authors： Huq A,Yunus M,Sohel SS,Bhuiya A,Emch M,Luby SP,Russek-Cohen E,Nair GB,Sack RB,Colwell RR

更新日期：2010-05-18 00:00:00

abstract：:Food-borne pathogens are ongoing problems, and new pathogens are emerging. The impact of fungi, however, is largely underestimated. Recently, commercial yogurts contaminated with Mucor circinelloides were sold, and >200 consumers became ill with nausea, vomiting, and diarrhea. Mucoralean fungi cause the fatal fungal i...

journal_title：mBio

authors： Lee SC,Billmyre RB,Li A,Carson S,Sykes SM,Huh EY,Mieczkowski P,Ko DC,Cuomo CA,Heitman J

更新日期：2014-07-08 00:00:00

abstract：:All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for ...

journal_title：mBio

authors： Guerardel Y,Sadovskaya I,Maes E,Furlan S,Chapot-Chartier MP,Mesnage S,Rigottier-Gois L,Serror P

更新日期：2020-04-28 00:00:00

abstract：:Merozoites formed after asexual division of the malaria parasite invade the host red blood cells (RBCs), which is critical for initiating malaria infection. The process of invasion involves specialized organelles like micronemes and rhoptries that discharge key proteins involved in interaction with host RBC receptors....

journal_title：mBio

authors： Ekka R,Gupta A,Bhatnagar S,Malhotra P,Sharma P

更新日期：2020-10-06 00:00:00

abstract：:Since the discovery of symbioses between sulfur-oxidizing (thiotrophic) bacteria and invertebrates at hydrothermal vents over 40 years ago, it has been assumed that autotrophic fixation of CO2 by the symbionts drives these nutritional associations. In this study, we investigated "Candidatus Kentron," the clade of symb...

journal_title：mBio

authors： Seah BKB,Antony CP,Huettel B,Zarzycki J,Schada von Borzyskowski L,Erb TJ,Kouris A,Kleiner M,Liebeke M,Dubilier N,Gruber-Vodicka HR

更新日期：2019-06-25 00:00:00

abstract：UNLABELLED:Similar to many eukaryotic viruses (and unlike bacteriophages), viruses infecting archaea are often encased in lipid-containing envelopes. However, the mechanisms of their morphogenesis and egress remain unexplored. Here, we used dual-axis electron tomography (ET) to characterize the morphogenesis of Sulfolo...

journal_title：mBio

authors： Quemin ER,Chlanda P,Sachse M,Forterre P,Prangishvili D,Krupovic M

更新日期：2016-09-13 00:00:00

abstract：:Innate immune response plays a critical role in controlling invading pathogens, but such an immune response must be tightly regulated. Insufficient or overactivated immune responses may lead to harmful or even fatal consequences. To dissect the complex host-parasite interactions and the molecular mechanisms underlying...

journal_title：mBio

authors： Cai B,Wu J,Yu X,Su XZ,Wang RF

更新日期：2017-01-03 00:00:00

abstract：:Streptococcus pneumoniae causes a high burden of invasive pneumococcal disease (IPD) globally, especially in children from resource-poor settings. Like many bacteria, the pneumococcus can import DNA from other strains or even species by transformation and homologous recombination, which has allowed the pneumococcus to...

journal_title：mBio

authors： Chaguza C,Andam CP,Harris SR,Cornick JE,Yang M,Bricio-Moreno L,Kamng'ona AW,Parkhill J,French N,Heyderman RS,Kadioglu A,Everett DB,Bentley SD,Hanage WP

更新日期：2016-09-27 00:00:00

abstract：:Burkholderia pseudomallei, the founding member of the B. pseudomallei complex (Bpc), is a biothreat agent and causes melioidosis, a disease whose treatment mainly relies on ceftazidime and meropenem. The concern is that B. pseudomallei could enhance its drug resistance repertoire by the acquisition of DNA from resista...

journal_title：mBio

authors： Somprasong N,Hall CM,Webb JR,Sahl JW,Wagner DM,Keim P,Currie BJ,Schweizer HP

更新日期：2020-04-14 00:00:00

abstract：:Epidemiological studies on Streptococcus pneumoniae show that rates of carriage are highest in early childhood and that the major benefit of the pneumococcal conjugate vaccine (PCV) is a reduction in the incidence of nasopharyngeal colonization through decreased transmission within a population. In this study, we soug...

journal_title：mBio

authors： Zangari T,Wang Y,Weiser JN

更新日期：2017-03-14 00:00:00

abstract：:Antimicrobial resistance is a major health threat as it limits treatment options for infection. At the forefront of this serious issue is Acinetobacter baumannii, a Gram-negative opportunistic pathogen that exhibits the remarkable ability to resist antibiotics through multiple mechanisms. As bacterial ribosomes repres...

journal_title：mBio

authors： Morgan CE,Huang W,Rudin SD,Taylor DJ,Kirby JE,Bonomo RA,Yu EW

更新日期：2020-01-21 00:00:00

abstract：UNLABELLED:The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening meningitis in immunocompromised individuals. The expression of virulence factors, including capsule and melanin, is in part regulated by the cyclic-AMP/protein kinase A (cAMP/PKA) signal transduction pathway. In this study, we ...

journal_title：mBio

authors： Geddes JM,Caza M,Croll D,Stoynov N,Foster LJ,Kronstad JW

更新日期：2016-01-12 00:00:00

abstract：UNLABELLED:Streptococcus pneumoniae (pneumococcus) is a frequent colonizer of the nasopharynx and one of the leading causative agents of otitis media, pneumonia, and meningitis. The current literature asserts that S. pneumoniae is transmitted person to person via respiratory droplets; however, environmental surfaces (f...

journal_title：mBio

authors： Walsh RL,Camilli A

更新日期：2011-05-24 00:00:00