Abstract：
:The removal and cryostorage of ovarian cortical biopsies is now offered as a fertility preservation option for young women. The only available option to restore fertility using this tissue is by transplantation, which may not be possible for all patients. The full potential of this tissue to restore fertility could be achieved by the development of in vitro systems that support oocyte development from the most immature stages to maturation. The techniques of in vitro growth (IVG) combined with in vitro maturation (IVM) are being developed with human tissue, but comparing different systems has been difficult because of the scarcity of tissue so nonhuman primates are being used as model systems. There are many challenges to developing a complete culture system that would support human oocyte development, and this review outlines the approaches being taken by several groups using tissue from women and nonhuman primate models to support each of the stages of oocyte development.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Telfer EE,Zelinski MBdoi
10.1016/j.fertnstert.2013.03.043subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1523-33issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(13)00459-7journal_volume
99pub_type
杂志文章,评审abstract：:A dry ejaculate (aspermia), may occur either because of an inability to transport semen (anejaculation) or because of an inability to ejaculate in an antegrade direction (retrograde ejaculation). The treatment of aspermia varies with underlying etiology and includes medical therapy with sympathomimetics, urinary sperm...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2015.09.024
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To evaluate whether intravaginal application of seminal plasma at the time of follicle aspiration in IVF or intracytoplasmic sperm injection treatment cycles has the potential to increase pregnancy rate. To calculate the number of patients needed to achieve significance in a multicenter trial. DESIGN:Double-...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2007.11.036
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To determine whether self-selected women with polycystic ovary syndrome (PCOS) are abnormal compared with a control population. DESIGN:Case-control. SETTING:Support group meeting organized and initiated by patients. PATIENT(S):Forty-five self-selected women with PCOS and 80 control women. INTERVENTION(S):...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)03153-9
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:To study the effects of peritoneal macrophages on endometrial cellular proliferation in an in vitro coculture model and to compare the magnitude of these effects between macrophages from women with endometriosis and normal women. DESIGN:Controlled study of peritoneal macrophage function. SETTING:University ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00292-7
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:To assess the activation status of peritoneal macrophages from women with endometriosis. DESIGN:Peritoneal macrophages from patients undergoing laparoscopy were tested for cytotoxic activity against a cultured hepatoma cell line. SETTING:Patients were tested at initial laparoscopy or at the completion of th...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVE:To assign cutoff values for human chorionic gonadotropin (beta-hCG) in pretreatment and after one methotrexate (MTX) cycle and determine its correspondence to the number of MTX cycles in successfully treated ectopic pregnancy. DESIGN:Retrospective study. SETTING:Polish university hospital. PATIENT(S):68 wo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.07.1775
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To report a novel technique for cervical reconstruction in a patient with congenital agenesis of the cervix. DESIGN:Case report. SETTING:University-based tertiary care hospital. PATIENT(S):A woman with congenital absence of the cervix, functional vagina, and adenomyosis uteri. INTERVENTION(S):Laparoscopic...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.02.007
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To establish a mouse model for endometriosis and to evaluate roles of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in the formation of disease. DESIGN:Experimental laboratory study. SETTING:A women's hospital in China. PATIENT(S) AND ANIMAL(S):Ten women with endometriosi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.12.083
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVE:To compare histologically and stereologically the endometriotic nodule of the rectovaginal septum to peritoneal endometriosis. DESIGN:Morphometric investigation, cytokeratin and vimentin content, and steroid receptor evaluation were performed on endometriotic tissue from the peritoneum (n = 52) and rectovagi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:To investigate relations between dose of GnRH antagonist and follicular phase characteristics. DESIGN:Randomized controlled multicenter trial. SETTING:Tertiary referral fertility centers. PATIENT(S):Three hundred and twenty-nine IVF patients. INTERVENTION(S):Ovarian stimulation for IVF with recombinant FS...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0015-0282(00)01789-1
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:To assess the relevant factors affecting patients' decision when choosing a clinic for private, self-funded IVF treatment. DESIGN:Prospective anonymous closed questionnaires. SETTING:Single tertiary-care private IVF center. PATIENT(S):New patients attending primary consultation in a period of 7 months from...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01751-4
更新日期：2001-05-01 00:00:00
abstract：OBJECTIVE:To study the morphological changes of apoptotic oocytes, and rates of in vitro maturation and apoptosis of human oocytes in relation to age. DESIGN:Prospective comparative study. SETTING:Reproductive medicine center. PATIENT(S):Women undergoing surgery for ovarian cysts. INTERVENTION(S):Oocytes were incub...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(00)01597-1
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of estrogen (E) alone or with cyclic, continuous, or interrupted P regimens on bone density in an aged rat model. DESIGN:Randomized controlled trial. ANIMALS:Twenty 12-month-old female Sprague-Dawley rats were sham operated (intact control) and 100 were ovariectomized (OVX). INTE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：OBJECTIVE:To investigate the expression kinetics of interleukin-1 receptors (IL-1R), receptor antagonist (IL-1RN), and monocyte chemotactic protein 1 (MCP-1) throughout early gestation in mice. DESIGN:Assessment of IL-1R, IL-1RN, and MCP-1 throughout early pregnancy. SETTING:Reproduction laboratory. ANIMAL(S):B6C3F1...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.01.011
更新日期：2014-04-01 00:00:00
abstract：OBJECTIVES:To evaluate prospectively the impact of subtle tubal disorders on GIFT pregnancy rates in women with pelvic endometriosis. DESIGN:A prospective comparison of pregnancy rates in different stages of endometriosis while controlling for the presence of tubal abnormalities. INTERVENTIONS:A total of 146 patients...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)57007-1
更新日期：1994-10-01 00:00:00
abstract：:A study was undertaken to examine the influence of pH on the migration of X and Y sperm as observed in freshly ejaculated semen samples from human donors. These sperm were allowed to migrate into capillary tubes containing media of varying pH. Y-carrying sperm were i dentified using flourescent staining with quinacr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)38224-3
更新日期：1971-05-01 00:00:00
abstract：OBJECTIVE:To determine whether progestins activate vascular endothelial growth factor (VEGF) gene transcription in endometrial adenocarcinoma cells. DESIGN:In vitro study. SETTING:University reproductive biology laboratories. PATIENT(S):None. INTERVENTION(S):Ishikawa cells were transfected with VEGF promoter-lucife...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04577-6
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVE:To determine the relationship between some reproductive variables and infertility caused by tubal obstruction. DESIGN:A retrospective, case-control study. SETTING:A tertiary care university hospital that is a referral center for infertility patients. PARTICIPANTS:Subjects were interviewed between March 199...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：OBJECTIVE:To analyze the efficacy of intracytoplasmic sperm injection (ICSI) for "rescue" of failed conventional insemination cycles. DESIGN:Retrospective clinical study. SETTING:Private infertility clinic. PATIENT(S):Fifty-four couples with non-male factor infertility undergoing routine IVF within our clinic. INTE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)00223-9
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To investigate the role(s) of colony-stimulating factor 1 (CSF-1) on the development of early endometriosis in a murine model by comparing rate of lesion formation in mice [1] homozygous for a CSF-1 mutation versus syngeneic controls and [2] after treatment with imatinib, a commercially available tyrosine kin...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.09.050
更新日期：2010-01-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the prognostic and therapeutic value of a Lupron (leuprolide acetate; Tap Pharmaceuticals, North Chicago, IL) screening test before ovarian stimulation for in vitro fertilization (IVF). DESIGN:Prospective. SETTING:Outpatient IVF program. PATIENTS:Eighty patients exhibited four early estra...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)54421-5
更新日期：1991-07-01 00:00:00
abstract：OBJECTIVE:To compare the euploidy outcome in patients that underwent 2 ovarian stimulation cycles with trophectoderm biopsy. DESIGN:Retrospective repeated-measures cohort study. SETTING:University-based fertility center. PATIENT(S):A total of 116 patients, from 2011 through 2013, that underwent 2 ovarian stimulation...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2014.12.126
更新日期：2015-04-01 00:00:00
abstract：:A monoclonal antibody that induces agglutination of human sperm was used to localize the interacting antigen in various tissues by indirect immunofluorescence. The antibody localized to the immature sperm and Sertoli cells of the seminiferous tubules, simple cuboidal epithelial cells of the rete testis, and the column...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48147-1
更新日期：1984-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of dienogest on the expression of Toll-like receptor (TLR) 4 in human endometrial epithelial cells. DESIGN:Prospective basic research study. SETTING:Pharmaceutical research center. PATIENT(S):None. INTERVENTION(S):Not applicable. MAIN OUTCOME MEASURE(S):TLR4 in the immortalized ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.09.040
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:To evaluate by serial ultrasound scans how long a Ringer's lactate instillation remains in the peritoneal cavity after laparoscopy. DESIGN:Prospective, randomized, double blind, clinical trial. SETTING:Tertiary care, university hospital. PATIENT(S):Thirty-six patients undergoing diagnostic or minor operati...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2005.01.111
更新日期：2005-07-01 00:00:00
abstract：:Synthetic LH-RH is a polypeptide that is structurally identical to natural LH-RH. It has been used as a safe ovulation induction agent. A case is presented in which a patient had an anaphylactic reaction when treated with LH-RH by IV infusion. Positive skin testing confirmed this as an IgE-mediated reaction. This is t...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59428-x
更新日期：1987-09-01 00:00:00
abstract：OBJECTIVE:To evaluate whether overweight and obesity are related to changes in serum sex hormone concentrations and semen quality. DESIGN:Cross-sectional study. SETTING:Data from five previous population-based environmental studies of semen quality were combined into one database at a university hospital in Denmark. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1292
更新日期：2008-09-01 00:00:00
abstract：:Melatonin plays an important role in many aspects of the human reproductive process. Our results first strongly suggest that MTNR1B mediating some functions of melatonin contributes to the phenotypic expression of polycystic ovary syndrome, which provide a new insight into the role of MTNR1B gene in the pathophysiolog...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.01.059
更新日期：2010-11-01 00:00:00
abstract：:Changes in the composition of media used for human in vitro fertilization and embryo culture are reviewed, and their impact on improved pregnancy rates is discussed. It is concluded that changes to the formulation of culture media for assisted reproductive technologies over the past decade have played a significant ro...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2003.10.003
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:To evaluate serial hormone concentrations in subjects treated with vaginally administered misoprostol for early pregnancy failure. DESIGN:As part of a randomized clinical trial, serum was collected on treatment days 1, 3, 8, and 15. SETTING:Multicenter clinical trial. PATIENT(S):Women with a nonviable firs...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2003.08.041
更新日期：2004-04-01 00:00:00
