Retinoids and butyrate modulate fibroblast growth and contraction of collagen matrices.

abstract：PURPOSE:To determine the effects of enzymes on mammalian vitreous gel and to thus infer the structural roles of hyaluronan and chondroitin sulfate in the gel. METHODS:The wet weights of bovine vitreous gels were compared before and after incubation with Streptomyces hyaluronan lyase, chondroitin ABC lyase, testicular ...

journal_title：Investigative ophthalmology & visual science

authors： Bishop PN,McLeod D,Reardon A

更新日期：1999-09-01 00:00:00

abstract：Purpose:To characterize the morphology of neovascularization at the disc (NVD) and neovascularization elsewhere (NVE) in treatment-naïve or previously treated proliferative diabetic retinopathy (PDR) patients using optical coherence tomography (OCT) angiography. Methods:En face OCT angiograms of NVD/NVE in 40 eyes of ...

journal_title：Investigative ophthalmology & visual science

authors： Ishibazawa A,Nagaoka T,Yokota H,Takahashi A,Omae T,Song YS,Takahashi T,Yoshida A

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To investigate the effects of reducing connexin (Cx) diversity in the lens when the amount of connexin protein is nearly constant. METHODS:Lenses in which the Cx50 coding region was replaced by that of Cx46 (knockin [KI]), were compared with wild type (WT) and Cx50-knockout (KO) lenses. Gap junctional conducta...

journal_title：Investigative ophthalmology & visual science

authors： Martinez-Wittinghan FJ,Sellitto C,White TW,Mathias RT,Paul D,Goodenough DA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:To determine the functional contribution of retinoic acid receptor (RAR)-alpha in the developing murine neural retina, through a phenotypic analysis of the corresponding null mutants. METHODS:RARalpha mutant (Rara(-/-)) mice were compared with wild-type littermates at several stages of pre- and postnatal devel...

journal_title：Investigative ophthalmology & visual science

authors： Cammas L,Trensz F,Jellali A,Ghyselinck NB,Roux MJ,Dollé P

更新日期：2010-06-01 00:00:00

abstract：Purpose:To investigate the roles and pathways of microRNAs 143 and 145 in transforming growth factor (TGF)-β1-induced human subconjunctival fibrosis. Methods:Human tenon's capsule fibroblasts (HTFs) were obtained from a healthy eye. After treating cultured HTFs with TGF-β1, the expression of microRNAs 143 and 145 was ...

journal_title：Investigative ophthalmology & visual science

authors： Hwang YH,Jung SA,Lyu J,Kim YY,Lee JH

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity makes it unusable for humans. A recently identified endogenous AHR lig...

journal_title：Investigative ophthalmology & visual science

authors： Nugent LF,Shi G,Vistica BP,Ogbeifun O,Hinshaw SJ,Gery I

更新日期：2013-11-13 00:00:00

abstract：:In order to determine the importance of lens actin filament configuration to lens accommodation, the pattern of actin filaments in the epithelium was studied in human lenses from different decades of life spanning the accommodative and non-accommodative years. Polygonal arrays of microfilaments were demonstrated in wh...

journal_title：Investigative ophthalmology & visual science

authors： Yeh S,Scholz DL,Liou W,Rafferty NS

更新日期：1986-10-01 00:00:00

abstract：PURPOSE:To examine changes in spherical equivalent over a 5-year period in persons 43 to 84 years of age. METHODS:All people 43 to 84 years of age and living in Beaver Dam, Wisconsin, in 1988 were invited for a baseline examination (1988-1990) and a 5-year follow-up examination (1993-1995). Refractions were determined...

journal_title：Investigative ophthalmology & visual science

authors： Lee KE,Klein BE,Klein R

更新日期：1999-07-01 00:00:00

abstract：Purpose:To identify the role of the BBSome protein Bardet-Biedl syndrome 5 (BBS5) in photoreceptor function, protein trafficking, and structure using a congenital mutant mouse model. Methods:Bbs5-/- mice (2 and 9 months old) were used to assess retinal function and morphology. Hematoxylin and eosin staining of retinal...

journal_title：Investigative ophthalmology & visual science

authors： Bales KL,Bentley MR,Croyle MJ,Kesterson RA,Yoder BK,Gross AK

更新日期：2020-08-03 00:00:00

abstract：:Recombinant human interferon alpha subtype D (RIFN alpha D) was effective in reducing the shedding of herpes simplex virus type-1 (HSV-1) induced by 6-hydroxydopamine iontophoresis followed by topical epinephrine application in previously infected rabbit corneas. A treatment schedule of RIFN alpha D, two drops QID was...

journal_title：Investigative ophthalmology & visual science

authors： Mayers M,Matli M,Okumoto M,Samy M,Smolin G

更新日期：1985-02-01 00:00:00

abstract：:The purpose of the current study was to investigate the relationship between systemic blood pressure (BP) and long posterior ciliary arterial (LPCA) blood flow (BF) in response to autonomic drugs, and to determine the types of receptors involved. LPCA BF was measured in anesthetized rabbits at the retrobulbar region u...

journal_title：Investigative ophthalmology & visual science

authors： Okubo H,Gherezhiher T,Koss MC

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To evaluate the functional treatment response 3 months and 12 months after monthly ranibizumab in neovascular age-related macular degeneration (NAMD). METHODS:Twenty-six eyes showing treatment-naïve NAMD were examined with the Heidelberg Spectralis OCT (SD-OCT) and the Nidek MP-1 microperimeter (MP) at baselin...

journal_title：Investigative ophthalmology & visual science

authors： Sulzbacher F,Kiss C,Kaider A,Roberts P,Munk M,Kroh ME,Sayegh R,Schmidt-Erfurth U

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Scleral proteoglycans were characterized from human donor eyes aged 2 months to 94 years to identify age-related changes in the synthesis and/or accumulation of these extracellular matrix components. METHODS:Newly synthesized proteoglycans (previously radiolabeled with 35SO4) and total accumulated scleral prot...

journal_title：Investigative ophthalmology & visual science

authors： Rada JA,Achen VR,Penugonda S,Schmidt RW,Mount BA

更新日期：2000-06-01 00:00:00

abstract：:Quantitative autoradiography was used to study the incorporation of 3H-thymidine into the retina of albino rats following in vivo exposure to 300-nm radiation. Relative to background labeling in unexposed eyes, there was 8-20 times as much label per unit area in the outer nuclear layer, inner nuclear layer, and gangli...

journal_title：Investigative ophthalmology & visual science

authors： Rapp LM,Jose JG,Pitts DG

更新日期：1985-03-01 00:00:00

abstract：PURPOSE:To identify the defective gene in the sex-linked, recessively inherited retinal dysplasia and degeneration (rdd) chicken and to search for the human equivalent disease. METHODS:Microsatellites from chicken chromosome Z were genotyped in 77 progeny of a carrier male (rdd/+) and an affected female (rdd/W), and c...

journal_title：Investigative ophthalmology & visual science

authors： Ali M,Hocking PM,McKibbin M,Finnegan S,Shires M,Poulter JA,Prescott K,Booth A,Raashid Y,Jafri H,Ruddle JB,Mackey DA,Jacobson SG,Toomes C,Lester DH,Burt DW,Curry WJ,Inglehearn CF

更新日期：2011-09-27 00:00:00

abstract：PURPOSE:Macrophages are thought to be the first line of defense in many infectious diseases and are present in high numbers in corneas with Acanthamoeba keratitis. Conjunctival macrophage depletion was performed in an animal model of Acanthamoeba infection to determine the importance of macrophages in this disease. ME...

journal_title：Investigative ophthalmology & visual science

authors： van Klink F,Taylor WM,Alizadeh H,Jager MJ,van Rooijen N,Niederkorn JY

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To evaluate the differential effects of ganglion cell depletion from experimental glaucoma on the relative metabolic activities of neurons in the parvo (P)- and magno (M)-cellular visual pathways of the macaque visual system. METHODS:Monocular experimental glaucoma was induced in monkeys (Macaca mulatta and M....

journal_title：Investigative ophthalmology & visual science

authors： Crawford ML,Harwerth RS,Smith EL 3rd,Shen F,Carter-Dawson L

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To investigate whether mucosal immune responses directed against the ubiquitous parasite Toxoplasma gondii can be detected in tears of healthy humans. METHODS:Nonstimulated tears and blood were obtained from 62 healthy humans (mean age, 35 +/- 10 [SD] years). Serum anti-T. gondii immunoglobulin titers were det...

journal_title：Investigative ophthalmology & visual science

authors： Meek B,Klaren VN,van Haeringen NJ,Kijlstra A,Peek R

更新日期：2000-08-01 00:00:00

abstract：Purpose:To investigate the topographic changes of the dark-adapted multifocal electroretinogram (mfERG) across adulthood in the central retina and compare the topography between macular versus extramacular, nasal versus temporal, and inferior versus superior retinal areas. Methods:Sixty-five subjects (18-88 years) rec...

journal_title：Investigative ophthalmology & visual science

authors： Panorgias A,Tillman M,Sutter EE,Moshiri A,Gerth-Kahlert C,Werner JS

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To examine the expression of matrix metalloproteinases (MMPs) and their inhibitors during the development of retinal neovascularization (NV) in a mouse model. METHODS:A well-characterized murine model of retinal NV was used to study the expression of specific MMPs (MMP-2, MMP-9, and MT1-MMP) and tissue inhibit...

journal_title：Investigative ophthalmology & visual science

authors： Majka S,McGuire P,Colombo S,Das A

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:In addition to photoreceptor degeneration, excessive light causes degenerative alterations in the inner retina and ganglion cell death. A disturbance in osmohomeostasis may be one causative factor for the alterations in the inner retina. Because Müller cells mediate inner retinal osmohomeostasis (mainly through...

journal_title：Investigative ophthalmology & visual science

authors： Iandiev I,Wurm A,Hollborn M,Wiedemann P,Grimm C,Remé CE,Reichenbach A,Pannicke T,Bringmann A

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To reevaluate the validity of the light scatter factor (LSF) formula of Paulsson and Sjöstrand, LSF = L/E (M2/M1-1), where L is the target luminance, E is the illuminance of the glare source at the eye, and M2 and M1 are modulation contrast thresholds measured with and without the glare source, respectively. Th...

journal_title：Investigative ophthalmology & visual science

authors： Whitaker D,Elliott DB,Steen R

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:We described the optical coherence tomography (OCT) features of diabetic macular ischemia (DMI), and correlate these findings with visual acuity (VA). METHODS:Clinical and imaging data were collected from 100 patients with type 2 diabetes. Qualitative grading of DMI severity was determined according to criteri...

journal_title：Investigative ophthalmology & visual science

authors： Sim DA,Keane PA,Fung S,Karampelas M,Sadda SR,Fruttiger M,Patel PJ,Tufail A,Egan CA

更新日期：2014-01-21 00:00:00

abstract：:Intraocular pressure response to systemically administered osmotic agents was studied in albino rabbits with one optic nerve transected and the fellow optic nerve left intact. There eas a significant increase in intraocular pressure of both eyes following water ingestion but no significant difference in the pressure r...

journal_title：Investigative ophthalmology & visual science

authors： Serafano DM,Brubaker RF

更新日期：1978-01-01 00:00:00

abstract：PURPOSE:Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. This study explores some functional features of optineurin and its mutants. METH...

journal_title：Investigative ophthalmology & visual science

authors： Chalasani ML,Radha V,Gupta V,Agarwal N,Balasubramanian D,Swarup G

更新日期：2007-04-01 00:00:00

abstract：Purpose:To determine the relationship between the sensitivity of the retina in the central 10° and the thickness of the retinal layers in patients with retinitis pigmentosa (RP). Methods:Fifty-two RP patients were studied. All of the patients had been examined by the Humphrey Field Analyzer 10-2 program (HFA10-2) and ...

journal_title：Investigative ophthalmology & visual science

authors： Sayo A,Ueno S,Kominami T,Okado S,Inooka D,Komori S,Terasaki H

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:To explore changes in iris curvature over a 2-year period. To investigate associations between iris curvature and ocular biometric parameters. To explore relationships between a number of nonocular measurements and ocular biometric parameters. METHODS:Schoolboys enrolled 2 years previously were invited to retu...

journal_title：Investigative ophthalmology & visual science

authors： Shah A,Lascaratos G,Garway-Heath DF,Foster PJ,Barton K

更新日期：2014-06-10 00:00:00

abstract：PURPOSE:To investigate whether apoptosis plays a notable role in degeneration of corneal endothelial cells in patients with Fuchs' dystrophy. METHODS:Forty-seven corneal buttons from 41 patients with Fuchs' dystrophy were studied. Nucleus labeling, transmission electron microscopy (TEM), and TdT-dUTP terminal nick-end...

journal_title：Investigative ophthalmology & visual science

authors： Borderie VM,Baudrimont M,Vallée A,Ereau TL,Gray F,Laroche L

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:Anterograde intraflagellar transport (IFT) is essential for photoreceptor outer segment formation and maintenance, as well as for opsin trafficking. However, the role of retrograde IFT in vertebrate photoreceptors remains unclear. The purpose of this study was to evaluate zebrafish photoreceptors lacking the re...

journal_title：Investigative ophthalmology & visual science

authors： Krock BL,Mills-Henry I,Perkins BD

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Glial cells are structurally and functionally linked to neuronal tissues. Pathologically, the cells may be activated and characterized by increased size and number and altered cellular properties. In glaucoma, pathologic mechanisms within the anterior optic nerve may include glial activation. This study examine...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Cioffi GA,Cull G,Dong J,Fortune B

更新日期：2002-04-01 00:00:00