Diagnosis of nontuberculous mycobacterial infections.

Abstract:

:The nontuberculous mycobacteria (NTM) are typically environmental organisms residing in soil and water. Although generally of low pathogenicity to humans, NTM can cause a wide array of clinical diseases; pulmonary disease is most frequent, followed by lymphadenitis in children, skin disease by M. marinum (particularly in fish tank fanciers), and other extrapulmonary or disseminated infections in severely immunocompromised patients. Of the >140 NTM species reported in the literature, 25 species have been strongly associated with NTM diseases; the remainder are environmental organisms rarely encountered in clinical samples. Correct species identification is very important because NTM species differ in their clinical relevance. Further, NTM differ strongly in their growth rate, temperature tolerance, and drug susceptibility. The diagnosis of NTM disease is complex and requires good communication between clinicians, radiologists, and microbiologists. Isolation of M. kansasii and (in northwestern Europe) M. malmoense from pulmonary specimens usually indicates disease, whereas Mycobacterium gordonae and, to a lesser extent, M. simiae or M. chelonae are typically contaminants rather than causative agents of true disease. Mycobacterium avium complex (MAC), M. xenopi, and M. abscessus form an intermediate category between these two extremes. This review covers the clinical and laboratory diagnosis of NTM diseases and particularities for the different disease types and patient populations. Because of limited sensitivity and specificity of symptoms, radiology, and direct microscopy of clinical samples, culture remains the gold standard. Yet culture is time consuming and demands the use of multiple media types and incubation temperatures to optimize the yield. Outside of reference centers, such elaborate culture algorithms are scarce.

authors

van Ingen J

doi

10.1055/s-0033-1333569

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

103-9

issue

1

eissn

1069-3424

issn

1098-9048

journal_volume

34

pub_type

杂志文章,评审
  • Role of chest computed tomography in prevention of occupational respiratory disease: review of recent literature.

    abstract::This review provides an update on literature published over the past 5 years that is relevant to using chest computed tomography (CT) as a tool for preventing occupational respiratory disease. An important area of investigation has been in the use of low-dose CT (LDCT) to screen asbestos-exposed populations for lung c...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1547348

    authors: Weissman DN

    更新日期:2015-06-01 00:00:00

  • Diagnostic modalities in sarcoidosis: BAL, EBUS, and PET.

    abstract::Advances have been made in minimally invasive diagnostic procedures in sarcoidosis, including bronchoalveolar lavage (BAL), endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA), and positron emission tomography (PET). Several independent groups found almost identical predictive values of t...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0030-1262207

    authors: Costabel U,Bonella F,Ohshimo S,Guzman J

    更新日期:2010-08-01 00:00:00

  • Community-Acquired Pneumonia in Latin America.

    abstract::Community-acquired pneumonia (CAP) is associated with significant morbidity and mortality in Latin America and the Caribbean (LAC) region. Poverty, socioeconomic factors, and malnutrition influence the incidence and outcome of CAP in LAC. In LAC, Streptococcus pneumoniae is the most frequent microorganism responsible ...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1592076

    authors: Iannella HA,Luna CM

    更新日期:2016-12-01 00:00:00

  • Pandemic (avian) influenza.

    abstract::Pandemics of influenza have been reported since the early sixteenth century. Recent pandemics include the Spanish flu (H1N1) from 1918 to 1920 (resulting in approximately 50 million deaths worldwide); the Asian flu (H2N2) from 1957 to 1958 (resulting in more than 1 million deaths); the Hong Kong flu (H3N2) from 1968 t...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2007-976488

    authors: Rajagopal S,Treanor J

    更新日期:2007-04-01 00:00:00

  • Fluid management in shock.

    abstract::Shock is a broad category of injury to the human body caused by a variety of insults. Fluid resuscitation is the cornerstone of initial therapy for nearly all forms of shock. This article reviews the basic physiology determining body fluid composition, the goals of fluid resuscitation in shock, the types of fluids ava...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2004-860982

    authors: Martin GS,Lewis CA

    更新日期:2004-12-01 00:00:00

  • Exposure-related diffuse lung disease.

    abstract::Practicing pulmonologists are often faced with the question of whether a lung disease is related to something in the patient's workplace, home, or recreational environment. Recognizing a lung disease as exposure related creates both opportunities and obligations for clinicians. In addition to managing the patient, the...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0028-1101272

    authors: Rose CS,Lynch DA,Cool CD

    更新日期:2008-12-01 00:00:00

  • Aspirin-exacerbated respiratory disease: update on pathogenesis and desensitization.

    abstract::Aspirin-exacerbated respiratory disease (AERD) is a unique syndrome of airway inflammation that frequently occurs in patients with nasal polyposis, chronic sinusitis, and asthma. These patients tend to have progressive and recalcitrant sinus disease requiring frequent surgical intervention and in many cases systemic c...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0032-1325618

    authors: White AA,Stevenson DD

    更新日期:2012-12-01 00:00:00

  • Invasive fungal infections in the intensive care unit.

    abstract::Invasive fungal infections, especially candidemia and systemic candidiasis, have become a major cause of morbidity and mortality in the last few decades. This comes in parallel with the major advances made in intensive care. Patients who are critically ill, in medical or surgical ICUs are especially at risk for CANDID...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0029-1246289

    authors: Vazquez JA

    更新日期:2010-02-01 00:00:00

  • Usual interstitial pneumonia.

    abstract::Usual interstitial pneumonia (UIP) is a distinct histological lesion observed in idiopathic pulmonary fibrosis (IPF) but can be found in other etiologies. The diagnosis of UIP can be established by surgical lung biopsy or by high-resolution thin-section computed tomographic (CT) scans (provided the radiographic featur...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2006-957335

    authors: Lynch JP 3rd,Saggar R,Weigt SS,Zisman DA,White ES

    更新日期:2006-12-01 00:00:00

  • Malignant Mesothelioma: Has Anything Changed?

    abstract::Malignant pleural mesothelioma is a rare cancer associated with asbestos exposure and portends a dismal prognosis. Its worldwide incidence has been increasing, and treatment options are currently suboptimal and noncurative. However, since the turn of the century, several encouraging steps have been made toward improvi...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1693406

    authors: Kim RY,Sterman DH,Haas AR

    更新日期:2019-06-01 00:00:00

  • Immunosuppressive and cytotoxic therapy: pharmacology, toxicities, and monitoring.

    abstract::Treatment strategies for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are evolving. Cyclophosphamide (CYC) plus corticosteroids (CSs) is the mainstay of therapy for generalized, multisystemic AAV. Historically, the combination of CYC plus CS was used for a minimum of 12 months, but concern a...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1279831

    authors: Wang T,Weigt SS,Belperio JA,Lynch JP 3rd

    更新日期:2011-06-01 00:00:00

  • Adult Care in Cystic Fibrosis.

    abstract::Cystic fibrosis (CF) is now more common in adults than children in countries with well-developed health care systems. The number of adults continues to increase and will further increase if the new cystic fibrosis transmembrane conductance regulator (CFTR) modulators are disease modifying. Most of the complex morbidit...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-3400289

    authors: Elborn JS

    更新日期:2019-12-01 00:00:00

  • Preventing hospitalization for COPD exacerbations.

    abstract::Severe chronic obstructive pulmonary disease (COPD) exacerbations requiring hospitalization are a major cause of morbidity and mortality. Recognition of the importance of COPD exacerbations has led to the knowledge that prevention of exacerbations and early treatment are important goals of COPD therapy. Preventive man...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0030-1254071

    authors: Bourbeau J

    更新日期:2010-06-01 00:00:00

  • Pleural effusions following cardiac injury and coronary artery bypass graft surgery.

    abstract::This article discusses the pleural effusions that occur with the post-cardiac injury (Dressler's) syndrome (PCIS) and those that occur after coronary artery bypass graft (CABG) surgery. The PCIS can occur after any type of cardiac injury and is thought to be due to anti-myocardial antibodies. The primary symptoms are ...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2001-18802

    authors: Light RW

    更新日期:2001-12-01 00:00:00

  • Lymphocytic interstitial pneumonia and other benign lymphoid disorders.

    abstract::Nonneoplastic pulmonary lymphoid disorders consist of a complex spectrum of diseases for pathologists and pulmonologists alike. Advances in our understanding of these disorders in recent years have led to revisions in the classification scheme. This review summarizes the clinicoradiological and pathological features o...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1325156

    authors: Tian X,Yi ES,Ryu JH

    更新日期:2012-10-01 00:00:00

  • Ventilator-Associated Pneumonia: The Role of Emerging Diagnostic Technologies.

    abstract::Antibiotic resistance has emerged as a key determinant of outcome in patients with serious infections along with the virulence of the underlying pathogen. Within the intensive care unit (ICU) setting, ventilator-associated pneumonia (VAP) is a common nosocomial infection that is frequently caused by multidrug-resistan...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1599224

    authors: Kollef MH,Burnham CD

    更新日期:2017-06-01 00:00:00

  • Non-genetic influences on cystic fibrosis lung disease: the role of sociodemographic characteristics, environmental exposures, and healthcare interventions.

    abstract::Patients with cystic fibrosis (CF) exhibit significant variability in the course and severity of the disease, and this variability is best interpreted in the context of an interaction between genetic and nongenetic determinants. While a small number of patients with "mild" mutations in the CF transmembrane conductance...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2004-815660

    authors: Schechter MS

    更新日期:2003-12-01 00:00:00

  • Organ dysfunction: general approach, epidemiology, and organ failure scores.

    abstract::Multiorgan dysfunction syndrome represents a continuum of cumulative organ dysfunction from very mildly altered function to total and, rarely, irreversible organ failure and is the major cause of death in the intensive care unit (ICU). The terms multiple organ failure syndrome (MOFS), multiple organ system failure (MO...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0031-1287862

    authors: Ferreira AM,Sakr Y

    更新日期:2011-10-01 00:00:00

  • Selective decontamination of the digestive tract (SDD): is the game worth the candle?

    abstract::Selective decontamination of the digestive tract (SDD) is an infection prevention strategy in intensive care unit (ICU) patients by topical administration of antibiotics to the mouth and stomach to eradicate potentially pathogenic bacteria and yeast that may cause infections. It also includes a short course of intrave...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0031-1275536

    authors: van Essen EH,de Jonge E

    更新日期:2011-04-01 00:00:00

  • Antibiotic resistance in hospitals and intensive care units: the problem and potential solutions.

    abstract::Antimicrobial resistance has generally increased over the past 5 decades, with occasional brief respites following the introduction of new antimicrobial classes. Resistance has been driven by bacterial genetic events, antibiotic pressures, and lapses in hospital hygiene. Recently promoted solutions to the problem of h...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2003-37922

    authors: Weinstein RA

    更新日期:2003-02-01 00:00:00

  • Prevention strategies for healthcare-associated pneumonia.

    abstract::Healthcare-associated pneumonia (HCAP) represents one of the largest subsets of patients with pneumonia. Based on epidemiological projections for the aging U.S. population, the number of hospitalizations for HCAP is expected to increase exponentially for the next several decades. The unique risk factors for colonizati...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0028-1119812

    authors: Morrow LE

    更新日期:2009-02-01 00:00:00

  • COPD in the elderly patient.

    abstract::The elderly are especially prone to the adverse health effects of chronic obstructive pulmonary disease (COPD), which is a common disorder in that population. While the prevalence and morbidity of COPD in the elderly are high, it is often undiagnosed and thus undertreated. The diagnosis of COPD is primarily based on t...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0030-1265900

    authors: Hanania NA,Sharma G,Sharafkhaneh A

    更新日期:2010-10-01 00:00:00

  • Sleep in the critically ill patient.

    abstract::The sleep of intensive care unit (ICU) patients is remarkably disrupted. Several studies, employing both subjective and objective measures of sleep quality, have demonstrated that critically ill patients exhibit severe sleep fragmentation and reduced restorative sleep, particularly a suppression of rapid eye movement ...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2001-13829

    authors: Cooper AB,Gabor JY,Hanly PJ

    更新日期:2001-01-01 00:00:00

  • Acute Cellular Rejection: Is It Still Relevant?

    abstract::Despite significant progress in the field of transplant immunology, acute cellular rejection (ACR) remains a very frequent complication after lung transplantation (LTx), with almost 30% of LTx recipients experiencing at least one episode of treated ACR during the first year of follow-up. Most episodes respond to the f...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1617424

    authors: Koutsokera A,Levy L,Pal P,Orchanian-Cheff A,Martinu T

    更新日期:2018-04-01 00:00:00

  • Selected controversies in cardiopulmonary resuscitation.

    abstract::Cardiopulmonary resuscitation (CPR) is performed frequently by paramedics, emergency department personnel, and inpatient physicians. Unfortunately, after more than 40 years of practice and study, there are still many controversies and unresolved treatment issues. This article focuses on four current controversies in C...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-2001-13839

    authors: White SJ,Himes D,Rouhani M,Slovis CM

    更新日期:2001-01-01 00:00:00

  • Percutaneous Tracheostomy.

    abstract::Tracheostomy is a commonly performed surgical procedure in intensive care units (ICUs). Over the past three decades, there has been a substantial body of evidence to suggest percutaneous tracheostomy (PT) is at least as safe as surgical tracheostomy (ST) in the hands of trained clinicians. In most institutions, PT is ...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1676573

    authors: Al-Shathri Z,Susanto I

    更新日期:2018-12-01 00:00:00

  • New and future therapies in pulmonary arterial hypertension.

    abstract::Pulmonary arterial hypertension (PAH) is defined as a mean pulmonary artery pressure greater then 25 mm Hg at rest and greater then 30 mm Hg with exercise in association with normal left heart filling pressures. However, many patients with PAH have much higher pulmonary artery pressures, which, untreated, can rapidly ...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-2005-916158

    authors: Bull TM

    更新日期:2005-08-01 00:00:00

  • The microbiome and emerging pathogens in cystic fibrosis and non-cystic fibrosis bronchiectasis.

    abstract::Chronic pulmonary sepsis is the predominant cause of morbidity for patients with cystic fibrosis (CF) and non-CF bronchiectasis. Previously it was thought that respiratory infection in these patients was mostly limited to a very small number of typical pathogens; however, in recent years there have been increasing rep...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1546752

    authors: Green H,Jones AM

    更新日期:2015-04-01 00:00:00

  • Who Is Safe to Extubate in the Neuroscience Intensive Care Unit?

    abstract::Patients admitted to the neuroscience intensive care unit (NICU) may have respiratory compromise from either central or peripheral neurological pathology, and may hence require intubation and mechanical ventilation for very diverse reasons. Liberation from invasive ventilation, that is, extubation, at the earliest pos...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1608773

    authors: Bösel J

    更新日期:2017-12-01 00:00:00

  • Treatment of lung cancer in the elderly patient.

    abstract::The median age of presentation with lung cancer is 71, making the elderly the dominant subgroup. Although some elderly patients are frail, others have great physiological reserve. Geriatric assessment can clarify the specific strengths and weaknesses of older patients, improving management. This assessment should, at ...

    journal_title:Seminars in respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1055/s-0033-1358560

    authors: Weiss J,Langer C

    更新日期:2013-12-01 00:00:00