Abstract:
:Usual interstitial pneumonia (UIP) is a distinct histological lesion observed in idiopathic pulmonary fibrosis (IPF) but can be found in other etiologies. The diagnosis of UIP can be established by surgical lung biopsy or by high-resolution thin-section computed tomographic (CT) scans (provided the radiographic features are classical). Historically, patients labeled as "IPF" encompassed a group of disorders, including UIP as well as other idiopathic interstitial pneumonias that differ from UIP in prognosis and responsiveness to therapy. Current recommendations from international consensus statements restrict the term IPF to patients with idiopathic UIP. The inciting cause(s) and pathogenesis of UIP have not been elucidated, but alveolar epithelial cell injury and dysregulation or altered phenotypic expression of fibroblasts are key elements. Inflammatory cells may play minor roles in initiating or propagating the fibrotic process. The prognosis of UIP is poor. Mean survival following diagnosis approximates 3 years. Current therapies are of unproven value. Corticosteroids or immunosuppressive agents have been most often used, but data affirming benefit are lacking. Lung transplantation is a viable option for patients failing medical therapy. This review discusses diagnostic criteria for UIP (both histopathological and radiographic), natural history and clinical course, and therapeutic approaches (both current and future).
journal_name
Semin Respir Crit Care Medjournal_title
Seminars in respiratory and critical care medicineauthors
Lynch JP 3rd,Saggar R,Weigt SS,Zisman DA,White ESdoi
10.1055/s-2006-957335subject
Has Abstractpub_date
2006-12-01 00:00:00pages
634-51issue
6eissn
1069-3424issn
1098-9048journal_volume
27pub_type
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
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abstract:: ...
journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
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pub_type: 杂志文章,评审
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
doi:10.1055/s-2001-15785
更新日期:2001-06-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
doi:10.1055/s-2003-37922
更新日期:2003-02-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
doi:10.1055/s-2005-925525
更新日期:2005-12-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1269828
更新日期:2010-12-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
doi:10.1055/s-2004-822306
更新日期:2004-02-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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journal_title:Seminars in respiratory and critical care medicine
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
abstract::Daily oral care with chlorhexidine for mechanically ventilated patients is ubiquitous in contemporary intensive care practice. The practice is predicated upon meta-analyses suggesting that adding chlorhexidine to daily oral care regimens can reduce ventilator-associated pneumonia (VAP) rates by up to 40%. Close analys...
journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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更新日期:2009-10-01 00:00:00
abstract::Cardiopulmonary resuscitation (CPR) is performed frequently by paramedics, emergency department personnel, and inpatient physicians. Unfortunately, after more than 40 years of practice and study, there are still many controversies and unresolved treatment issues. This article focuses on four current controversies in C...
journal_title:Seminars in respiratory and critical care medicine
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更新日期:2001-01-01 00:00:00
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journal_title:Seminars in respiratory and critical care medicine
pub_type: 杂志文章,评审
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