Immunosuppressive and cytotoxic therapy: pharmacology, toxicities, and monitoring.

abstract：:The evolution of scientific investigation in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is replete with examples of effective bench-to-bedside transitions, pioneering research methodology, and international collaboration. This article highlights for clinicians a selection of challenges and ...

journal_title：Seminars in respiratory and critical care medicine

authors： Meade MO,Lamontagne F

更新日期：2013-08-01 00:00:00

abstract：:When Dr. Joseph Lynch, editor of Seminars in Respiratory and Critical Care Medicine, invited us to organize and edit this topic we-and our contributors-were initially baffled about how we could marry outcomes, ethics, and economics. His perspective as an elder-statesman, who has observed the evolution of critical care...

journal_title：Seminars in respiratory and critical care medicine

authors： Manthous CA,White DB,Carson SS

更新日期：2012-08-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is defined as a mean pulmonary artery pressure greater then 25 mm Hg at rest and greater then 30 mm Hg with exercise in association with normal left heart filling pressures. However, many patients with PAH have much higher pulmonary artery pressures, which, untreated, can rapidly ...

journal_title：Seminars in respiratory and critical care medicine

authors： Bull TM

更新日期：2005-08-01 00:00:00

abstract：:Lung transplant has become an established therapy in the treatment of end-stage lung disease. Many of the advances in the modern immunosuppression regimen have provided more quality and quantity of life to transplant patients. Immunosuppression agents target various aspects of the immune system to maximize graft toler...

journal_title：Seminars in respiratory and critical care medicine

authors： Floreth T,Bhorade SM

更新日期：2010-04-01 00:00:00

abstract：:This article discusses the pleural effusions that occur with the post-cardiac injury (Dressler's) syndrome (PCIS) and those that occur after coronary artery bypass graft (CABG) surgery. The PCIS can occur after any type of cardiac injury and is thought to be due to anti-myocardial antibodies. The primary symptoms are ...

journal_title：Seminars in respiratory and critical care medicine

authors： Light RW

更新日期：2001-12-01 00:00:00

abstract：:Asthma is a heterogeneous disorder with a complex etiology. Prevalence rates for asthma have been increasing in many countries over the past few decades. While it is unclear why this increase is occurring, the variation reported in asthma prevalence and severity associated with ethnicity offers some insight into the d...

journal_title：Seminars in respiratory and critical care medicine

authors： Moraes TJ,Sears MR,Subbarao P

更新日期：2018-02-01 00:00:00

abstract：:Chronic pulmonary sepsis is the predominant cause of morbidity for patients with cystic fibrosis (CF) and non-CF bronchiectasis. Previously it was thought that respiratory infection in these patients was mostly limited to a very small number of typical pathogens; however, in recent years there have been increasing rep...

journal_title：Seminars in respiratory and critical care medicine

authors： Green H,Jones AM

更新日期：2015-04-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is primarily a disease of the elderly. Although NSCLC is the leading cause of cancer death in the United States and the overall prognosis of this disease is poor, treatment improves survival compared with best supportive care, independent of the stage of disease. Elderly patients hav...

journal_title：Seminars in respiratory and critical care medicine

authors： Sequist LV,Fidias P

更新日期：2005-06-01 00:00:00

abstract：:The human Herpesviridae family consists of eight members: cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 and 2 (HSV-1, -2), varicella-zoster virus (VZV), and human herpesvirus 6, 7, and 8 (HHV-6, -7, -8). Lifelong latency may develop in the host with reactivation during periods of relative imm...

journal_title：Seminars in respiratory and critical care medicine

authors： Zamora MR

更新日期：2011-08-01 00:00:00

abstract：:Nonneoplastic pulmonary lymphoid disorders consist of a complex spectrum of diseases for pathologists and pulmonologists alike. Advances in our understanding of these disorders in recent years have led to revisions in the classification scheme. This review summarizes the clinicoradiological and pathological features o...

journal_title：Seminars in respiratory and critical care medicine

authors： Tian X,Yi ES,Ryu JH

更新日期：2012-10-01 00:00:00

abstract：:Despite recent advances in understanding, the management of acute respiratory distress syndrome (ARDS) remains a challenging clinical problem. Optimization of gas exchange and preventing the iatrogenic propagation of lung injury are cornerstones of its clinical management. A number of novel approaches and adjuncts to ...

journal_title：Seminars in respiratory and critical care medicine

authors： Kress JP,Marini JJ

更新日期：2001-06-01 00:00:00

abstract：:Accurate diagnosis of deep vein thrombosis is important because untreated deep vein thrombosis can cause death or permanent impairment and because effective treatments are available. The approach to the diagnosis of deep vein thrombosis varies because of differences in local resources and expertise. Duplex ultrasonogr...

journal_title：Seminars in respiratory and critical care medicine

authors： Elliott CG

更新日期：2000-01-01 00:00:00

abstract：:Patients admitted to the neuroscience intensive care unit (NICU) may have respiratory compromise from either central or peripheral neurological pathology, and may hence require intubation and mechanical ventilation for very diverse reasons. Liberation from invasive ventilation, that is, extubation, at the earliest pos...

journal_title：Seminars in respiratory and critical care medicine

authors： Bösel J

更新日期：2017-12-01 00:00:00

abstract：:Critically ill intensive care unit (ICU) patients often require sedation to tolerate life-saving interventions such as mechanical ventilation. Pain, anxiety, and delirium all contribute to patient distress and agitation which can interfere with ICU medical care if not addressed and treated appropriately. Sedation prac...

journal_title：Seminars in respiratory and critical care medicine

authors： DeBiasi EM,Akgün KM,Pisani M

更新日期：2015-12-01 00:00:00

abstract：:Computed tomography (CT) is the core imaging modality for the evaluation of thoracic disorders. With the recently developed dual-energy CT (DECT) technique, the clinical utility of CT in the management of pulmonary diseases can be expanded. The most actively investigated principle of dual energy is material decomposit...

journal_title：Seminars in respiratory and critical care medicine

authors： Remy-Jardin M,Faivre JB,Pontana F,Molinari F,Tacelli N,Remy J

更新日期：2014-02-01 00:00:00

abstract：:The genus Scedosporium comprises a group of filamentous fungi found ubiquitously in the environment. The two major human pathogens within this genus are S. apiospermum-the asexual state of Pseudallescheria boydii-and S. prolificans. Both histologically resemble Aspergillus species, with hyphae that are septated and br...

journal_title：Seminars in respiratory and critical care medicine

authors： Panackal AA,Marr KA

更新日期：2004-04-01 00:00:00

abstract：:Antibiotic resistance has emerged as a key determinant of outcome in patients with serious infections along with the virulence of the underlying pathogen. Within the intensive care unit (ICU) setting, ventilator-associated pneumonia (VAP) is a common nosocomial infection that is frequently caused by multidrug-resistan...

journal_title：Seminars in respiratory and critical care medicine

authors： Kollef MH,Burnham CD

更新日期：2017-06-01 00:00:00

abstract：:Multiorgan dysfunction syndrome represents a continuum of cumulative organ dysfunction from very mildly altered function to total and, rarely, irreversible organ failure and is the major cause of death in the intensive care unit (ICU). The terms multiple organ failure syndrome (MOFS), multiple organ system failure (MO...

journal_title：Seminars in respiratory and critical care medicine

authors： Ferreira AM,Sakr Y

更新日期：2011-10-01 00:00:00

abstract：:This review summarizes the effects of beta2-agonists on asthma severity. There has been a controversy as to whether the regularly scheduled use of beta2-adrenergic agonists increases the risk of adverse outcomes in asthma. A number of epidemiological and clinical studies have found an association between the regularly...

journal_title：Seminars in respiratory and critical care medicine

authors： Ford JG,Iqbal J,Sunmonu Y

更新日期：2002-08-01 00:00:00

abstract：:Practicing pulmonologists are often faced with the question of whether a lung disease is related to something in the patient's workplace, home, or recreational environment. Recognizing a lung disease as exposure related creates both opportunities and obligations for clinicians. In addition to managing the patient, the...

journal_title：Seminars in respiratory and critical care medicine

authors： Rose CS,Lynch DA,Cool CD

更新日期：2008-12-01 00:00:00

abstract：:In patients with acute intracerebral hemorrhage (ICH), one of the major concerns is ongoing bleeding or ICH expansion. Anticoagulated patients are at higher risk of ongoing expansion and worse outcome. It may be that rapid anticoagulation reversal can reduce the risk of expansion and improve clinical outcome. For thos...

journal_title：Seminars in respiratory and critical care medicine

authors： Fuh L,Sin JH,Goldstein JN,Hayes BD

更新日期：2017-12-01 00:00:00

abstract：:Amyloidosis is the term given to abnormal deposition of misfolded precursor proteins at single or multiple sites, leading to organ dysfunction or clinical signs and symptoms. Pulmonary manifestations are nonspecific and may be associated with several amyloid protein subtypes, commonly AL (light chain) and AA (autoimmu...

journal_title：Seminars in respiratory and critical care medicine

authors： Baqir M,Roden AC,Moua T

更新日期：2020-04-01 00:00:00

abstract：:Usual interstitial pneumonia (UIP) is a distinct histological lesion observed in idiopathic pulmonary fibrosis (IPF) but can be found in other etiologies. The diagnosis of UIP can be established by surgical lung biopsy or by high-resolution thin-section computed tomographic (CT) scans (provided the radiographic featur...

journal_title：Seminars in respiratory and critical care medicine

authors： Lynch JP 3rd,Saggar R,Weigt SS,Zisman DA,White ES

更新日期：2006-12-01 00:00:00

abstract：:MYCOBACTERIUM AVIUM complex (MAC) consists of nontuberculous mycobacteria that cause disease in immunocompromised and immunocompetent hosts. The organisms are ubiquitous in the environment, and acquisition occurs through ingestion or inhalation of aerosols from soil, water, or biofilms. Disease may manifest as dissemi...

journal_title：Seminars in respiratory and critical care medicine

authors： Kasperbauer SH,Daley CL

更新日期：2008-10-01 00:00:00

abstract：:Ultrasonography of the thorax has become a more recognized tool in pulmonary medicine, thanks to continuing clinical research that has proven its many valuable roles in the day-to-day management of pulmonary and pleural diseases. Ultrasound examination is a cost-effective imaging modality that permits the pulmonologis...

journal_title：Seminars in respiratory and critical care medicine

authors： Shojaee S,Argento AC

更新日期：2014-12-01 00:00:00

abstract：:Vasculitides are a heterogeneous group of disorders in which inflammation of blood vessel walls is present at least some time during the course of the disease. Vasculitides can affect any caliber or type of vessel in many anatomic sites; however, the disease can alter more than just vasculature. Given the diversity of...

journal_title：Seminars in respiratory and critical care medicine

authors： Scapa JV,Fishbein GA,Wallace WD,Fishbein MC

更新日期：2018-08-01 00:00:00

abstract：:Over the past 3 decades, antimicrobial resistance among Streptococcus pneumoniae, the most common cause of community-acquired pneumonia (CAP), has escalated dramatically worldwide. In the late 1970s, strains of pneumococci displaying resistance to penicillin were described in South Africa and Spain. By the early 1990s...

journal_title：Seminars in respiratory and critical care medicine

authors： Lynch JP 3rd,Zhanel GG

更新日期：2009-04-01 00:00:00

abstract：:Lung-protective ventilator strategies are considered standard practice in the care of patients with the acute respiratory distress syndrome (ARDS). To minimize ventilator-induced lung injury, attention is directed at avoidance of alveolar overdistention and cyclical opening and closing. The lowest possible plateau pre...

journal_title：Seminars in respiratory and critical care medicine

authors： Hess DR

更新日期：2014-08-01 00:00:00

abstract：:Advances have been made in minimally invasive diagnostic procedures in sarcoidosis, including bronchoalveolar lavage (BAL), endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA), and positron emission tomography (PET). Several independent groups found almost identical predictive values of t...

journal_title：Seminars in respiratory and critical care medicine

authors： Costabel U,Bonella F,Ohshimo S,Guzman J

更新日期：2010-08-01 00:00:00

abstract：:Intensive care unit (ICU) acquired pneumonia is one of the most common and morbid health care-associated infections. Despite decades of work developing and testing prevention strategies, ICU-acquired pneumonia remains stubbornly pervasive. Pneumonia prevention studies are difficult to interpret because all are at risk...

journal_title：Seminars in respiratory and critical care medicine

authors： Klompas M

更新日期：2019-08-01 00:00:00