Exposure-related diffuse lung disease.

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease of unknown cause, occurring in adults, limited to the lungs and associated with the pathologic and radiologic pattern of usual interstitial pneumonia. Prognosis is poor, and most patients die of respiratory failure within 3 to 6 years from the o...

journal_title：Seminars in respiratory and critical care medicine

authors： Puglisi S,Torrisi SE,Giuliano R,Vindigni V,Vancheri C

更新日期：2016-06-01 00:00:00

abstract：:In patients with acute intracerebral hemorrhage (ICH), one of the major concerns is ongoing bleeding or ICH expansion. Anticoagulated patients are at higher risk of ongoing expansion and worse outcome. It may be that rapid anticoagulation reversal can reduce the risk of expansion and improve clinical outcome. For thos...

journal_title：Seminars in respiratory and critical care medicine

authors： Fuh L,Sin JH,Goldstein JN,Hayes BD

更新日期：2017-12-01 00:00:00

abstract：:The diaphragm is the most important muscle of ventilation. Its contraction is key to the development of intrathoracic pressures. Diseases that affect diaphragmatic function result in decreased pressure-generating capacity by the respiratory muscles. If the involvement is severe or if there is underlying respiratory pa...

journal_title：Seminars in respiratory and critical care medicine

authors： Celli BR

更新日期：2002-06-01 00:00:00

abstract：:Cystic fibrosis (CF) is now more common in adults than children in countries with well-developed health care systems. The number of adults continues to increase and will further increase if the new cystic fibrosis transmembrane conductance regulator (CFTR) modulators are disease modifying. Most of the complex morbidit...

journal_title：Seminars in respiratory and critical care medicine

authors： Elborn JS

更新日期：2019-12-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and the leading cause of cancer-related death. Although durable local control rates are high after surgical resection or definitive radiotherapy for early-stage disease, a substantial proportion of these patients eventually experience regiona...

journal_title：Seminars in respiratory and critical care medicine

authors： Dams RV,Yuan Y,Robinson CG,Lee P

更新日期：2020-06-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) in the pediatric population is associated with a variety of underlying diseases and causes, significantly morbidity and mortality. In the majority of patients, PAH in children is idiopathic or associated with congenital heart disease (CHD), with pulmonary hypertension (PH) associa...

journal_title：Seminars in respiratory and critical care medicine

authors： Takatsuki S,Ivy DD

更新日期：2013-10-01 00:00:00

abstract：:MYCOBACTERIUM AVIUM complex (MAC) consists of nontuberculous mycobacteria that cause disease in immunocompromised and immunocompetent hosts. The organisms are ubiquitous in the environment, and acquisition occurs through ingestion or inhalation of aerosols from soil, water, or biofilms. Disease may manifest as dissemi...

journal_title：Seminars in respiratory and critical care medicine

authors： Kasperbauer SH,Daley CL

更新日期：2008-10-01 00:00:00

abstract：:Invasive fungal infections, especially candidemia and systemic candidiasis, have become a major cause of morbidity and mortality in the last few decades. This comes in parallel with the major advances made in intensive care. Patients who are critically ill, in medical or surgical ICUs are especially at risk for CANDID...

journal_title：Seminars in respiratory and critical care medicine

authors： Vazquez JA

更新日期：2010-02-01 00:00:00

abstract：:The sleep of intensive care unit (ICU) patients is remarkably disrupted. Several studies, employing both subjective and objective measures of sleep quality, have demonstrated that critically ill patients exhibit severe sleep fragmentation and reduced restorative sleep, particularly a suppression of rapid eye movement ...

journal_title：Seminars in respiratory and critical care medicine

authors： Cooper AB,Gabor JY,Hanly PJ

更新日期：2001-01-01 00:00:00

abstract：:Over the past 3 decades, antimicrobial resistance among Streptococcus pneumoniae, the most common cause of community-acquired pneumonia (CAP), has escalated dramatically worldwide. In the late 1970s, strains of pneumococci displaying resistance to penicillin were described in South Africa and Spain. By the early 1990s...

journal_title：Seminars in respiratory and critical care medicine

authors： Lynch JP 3rd,Zhanel GG

更新日期：2009-04-01 00:00:00

abstract：:Despite recent advances in understanding, the management of acute respiratory distress syndrome (ARDS) remains a challenging clinical problem. Optimization of gas exchange and preventing the iatrogenic propagation of lung injury are cornerstones of its clinical management. A number of novel approaches and adjuncts to ...

journal_title：Seminars in respiratory and critical care medicine

authors： Kress JP,Marini JJ

更新日期：2001-06-01 00:00:00

abstract：:This article reviews recent developments in the selection, assessment, and management of the potential lung donor, which aim to increase donor organ use. The scarcity of suitable donor organs continues to limit lung transplantation, but the situation is changing. An expanded donor pool, including the now widespread us...

journal_title：Seminars in respiratory and critical care medicine

authors： Snell GI,Paraskeva M,Westall GP

更新日期：2013-06-01 00:00:00

abstract：:The management of patients suspected of having ventilator-associated pneumonia (VAP) requires a strategy for diagnosis and treatment that is designated to: (1) identify patients with true lung bacterial infection; (2) determine the pathogen(s) responsible for pneumonia; (3) permit early selection of appropriate antimi...

journal_title：Seminars in respiratory and critical care medicine

authors： Fagon JY

更新日期：2006-02-01 00:00:00

abstract：:Multiorgan dysfunction syndrome represents a continuum of cumulative organ dysfunction from very mildly altered function to total and, rarely, irreversible organ failure and is the major cause of death in the intensive care unit (ICU). The terms multiple organ failure syndrome (MOFS), multiple organ system failure (MO...

journal_title：Seminars in respiratory and critical care medicine

authors： Ferreira AM,Sakr Y

更新日期：2011-10-01 00:00:00

abstract：:Among immunocompromised individuals, members of the human Herpesviridae family are frequently encountered pathogens. Cytomegalovirus, herpes simplex virus 1 and 2, varicella zoster virus, Epstein-Barr virus, and human herpesvirus-6, -7, and -8 all establish latency after infection and can reactivate during periods of ...

journal_title：Seminars in respiratory and critical care medicine

authors： Reid GE,Lynch JP 3rd,Weigt S,Sayah D,Belperio JA,Grim SA,Clark NM

更新日期：2016-08-01 00:00:00

abstract：:Patients with cystic fibrosis (CF) exhibit significant variability in the course and severity of the disease, and this variability is best interpreted in the context of an interaction between genetic and nongenetic determinants. While a small number of patients with "mild" mutations in the CF transmembrane conductance...

journal_title：Seminars in respiratory and critical care medicine

authors： Schechter MS

更新日期：2003-12-01 00:00:00

abstract：:A significant number of drugs and toxins have been associated with eosinophilic pneumonia. Antibiotics and NSAID, are the most commonly reported drugs. Toxins suspected to cause eosinophilic pneumonia include cigarette smoke and illicit drugs. Drug- or toxin-induced eosinophilic pneumonia is indistinguishable from idi...

journal_title：Seminars in respiratory and critical care medicine

authors： Solomon J,Schwarz M

更新日期：2006-04-01 00:00:00

abstract：:The vasculitides affecting large and medium-sized vessels are heterogeneous. This group includes such disorders as giant cell arteritis, Takayasu's disease, and sarcoidosis. There are several challenges that may arise in the care of patients with these disorders. Diagnosis may be elusive when initially evaluating pati...

journal_title：Seminars in respiratory and critical care medicine

authors： Maksimowicz-McKinnon K,Hoffman GS

更新日期：2004-10-01 00:00:00

abstract：:Assisted mechanical ventilation (MV) may be a favorable alternative to controlled MV at the early phase of acute respiratory distress syndrome (ARDS), since it requires less sedation, no paralysis and is associated with less hemodynamic deterioration, better distal organ perfusion, and lung protection, thus reducing t...

journal_title：Seminars in respiratory and critical care medicine

authors： Saddy F,Sutherasan Y,Rocco PR,Pelosi P

更新日期：2014-08-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is defined as a mean pulmonary artery pressure greater then 25 mm Hg at rest and greater then 30 mm Hg with exercise in association with normal left heart filling pressures. However, many patients with PAH have much higher pulmonary artery pressures, which, untreated, can rapidly ...

journal_title：Seminars in respiratory and critical care medicine

authors： Bull TM

更新日期：2005-08-01 00:00:00

abstract：:Mechanical ventilation practices in patients with acute respiratory distress syndrome (ARDS) have progressed with a growing understanding of the disease pathophysiology. Paramount to the care of affected patients is the delivery of lung-protective mechanical ventilation which prioritizes tidal volume and plateau press...

journal_title：Seminars in respiratory and critical care medicine

authors： Sklar MC,Patel BK,Beitler JR,Piraino T,Goligher EC

更新日期：2019-02-01 00:00:00

abstract：:Daily oral care with chlorhexidine for mechanically ventilated patients is ubiquitous in contemporary intensive care practice. The practice is predicated upon meta-analyses suggesting that adding chlorhexidine to daily oral care regimens can reduce ventilator-associated pneumonia (VAP) rates by up to 40%. Close analys...

journal_title：Seminars in respiratory and critical care medicine

authors： Klompas M

更新日期：2017-06-01 00:00:00

abstract：:Despite advances in positive pressure therapy for obstructive sleep apnea, compliance continues to be a problem for many patients. Sleep apnea surgery is a viable option for patients who are intolerant of positive pressure therapy. This review presents the current state of the art in sleep apnea surgery, including air...

journal_title：Seminars in respiratory and critical care medicine

authors： Li KK

更新日期：2005-02-01 00:00:00

abstract：:Nonspecific interstitial pneumonia (NSIP) represents one histologic subtype of idiopathic interstitial pneumonia (IIP). NSIP is typified by temporal homogeneity and less profusion of fibroblastic foci than is seen with usual interstitial pneumonia (UIP), the most common IIP. Clinically patients with NSIP present with ...

journal_title：Seminars in respiratory and critical care medicine

authors： Flaherty KR,Martinez FJ,Travis W,Lynch JP 3rd

更新日期：2001-08-01 00:00:00

abstract：:Hepatic sarcoidosis is a relatively common manifestation of extrapulmonary sarcoidosis. It occurs in 20 to 30% of cases and is rarely severe. However, a cluster of patients may develop severe complications such as cirrhosis and portal hypertension. In this review, we describe the current knowledge of clinical, biologi...

journal_title：Seminars in respiratory and critical care medicine

authors： Rossi G,Ziol M,Roulot D,Valeyre D,Mahévas M

更新日期：2020-10-01 00:00:00

abstract：:Treatment strategies for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are evolving. Cyclophosphamide (CYC) plus corticosteroids (CSs) is the mainstay of therapy for generalized, multisystemic AAV. Historically, the combination of CYC plus CS was used for a minimum of 12 months, but concern a...

journal_title：Seminars in respiratory and critical care medicine

authors： Wang T,Weigt SS,Belperio JA,Lynch JP 3rd

更新日期：2011-06-01 00:00:00

abstract：: ...

journal_title：Seminars in respiratory and critical care medicine

authors： Oh SS,Folch E

更新日期：2018-12-01 00:00:00

abstract：:Selective decontamination of the digestive tract (SDD) is an infection prevention strategy in intensive care unit (ICU) patients by topical administration of antibiotics to the mouth and stomach to eradicate potentially pathogenic bacteria and yeast that may cause infections. It also includes a short course of intrave...

journal_title：Seminars in respiratory and critical care medicine

authors： van Essen EH,de Jonge E

更新日期：2011-04-01 00:00:00

abstract：:Delivery of medication to sites of action through airways has been used for centuries but has gained momentum in recent decades. Currently available modes of aerosol delivery offer advantages but still there are shortcomings. Delivery of active agents to sites of action is affected by many factors beyond the character...

journal_title：Seminars in respiratory and critical care medicine

authors： Singh S,Kanbar-Agha F,Sharafkhaneh A

更新日期：2015-08-01 00:00:00

abstract：:Aspirin-exacerbated respiratory disease (AERD) is a unique syndrome of airway inflammation that frequently occurs in patients with nasal polyposis, chronic sinusitis, and asthma. These patients tend to have progressive and recalcitrant sinus disease requiring frequent surgical intervention and in many cases systemic c...

journal_title：Seminars in respiratory and critical care medicine

authors： White AA,Stevenson DD

更新日期：2012-12-01 00:00:00