Abstract:
:The effects of high dose injections of corticotropin-releasing hormone (CRH) on the adrenal cortex of hypophysectomized rats were studied at the light- and electron-microscopical levels. Adrenocortical atrophy induced by hypophysectomy could be reduced by daily i.p. injection of 10 micrograms (3 nmol) CRH given for 3 days starting at day 5 after the operation. The cortex broadened, mostly because of hypertrophy of the zona fasciculata. Blood vessels were enlarged. Although the adrenocortical cells of hypophysectomized rats showed features of a functionally suppressed state, such as tubular mitochondria, the cells of CRH-treated animals showed characteristics of stimulated cells. The inner membrane of the mitochondria formed the typical densely packed vesicles of adrenocortical cells that are active in steroidogenesis. Lipid droplets were found to be reduced, and the cells developed filopodia at their surface. These morphological observations indicate that CRH influences the adrenal cortex via extrapituitary mechanisms.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Bornstein SR,Ehrhart M,Scherbaum WA,Pfeiffer EFdoi
10.1007/BF00297501subject
Has Abstractpub_date
1990-04-01 00:00:00pages
161-6issue
1eissn
0302-766Xissn
1432-0878journal_volume
260pub_type
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