Evolution of resistance to satyrization through reproductive character displacement in populations of invasive dengue vectors.

abstract：:Lipid rafts are important signaling platforms in T cells. Little is known about their properties in human CD8(+) T cells. We studied polarization of lipid rafts by digital immunofluorescence microscopy in primary human T cells, using beads coated with anti-CD3 and anti-CD28 mAbs (CD3/28 beads). Unlike CD4(+) T cells, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovacs B,Maus MV,Riley JL,Derimanov GS,Koretzky GA,June CH,Finkel TH

更新日期：2002-11-12 00:00:00

abstract：:Genetic and taxonomic distances were computed for 3466 samples of human populations in Europe based on 97 allele frequencies and 10 cranial variables. Since the actual samples employed differed among the genetic systems studied, the genetic distances were computed separately for each system, as were matrices of geogra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokal RR

更新日期：1988-03-01 00:00:00

abstract：:Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types. Using stringent thresholding criteria, we identified 3,707 s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Londin E,Loher P,Telonis AG,Quann K,Clark P,Jing Y,Hatzimichael E,Kirino Y,Honda S,Lally M,Ramratnam B,Comstock CE,Knudsen KE,Gomella L,Spaeth GL,Hark L,Katz LJ,Witkiewicz A,Rostami A,Jimenez SA,Hollingsworth MA,

更新日期：2015-03-10 00:00:00

abstract：:Fibroblasts can condense a hydrated collagen lattice to a tissue-like structure 1/28th the area of the starting gel in 24 hr. The rate of the process can be regulated by varying the protein content of the lattice, the cell number, or the concentration of an inhibitor such as Colcemid. Fibroblasts of high population do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bell E,Ivarsson B,Merrill C

更新日期：1979-03-01 00:00:00

abstract：:Caenorhabditis elegans sqv mutants are defective in vulval epithelial invagination and have a severe reduction in hermaphrodite fertility. The gene sqv-7 encodes a multitransmembrane hydrophobic protein resembling nucleotide sugar transporters of the Golgi membrane. A Golgi vesicle enriched fraction of Saccharomyces c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berninsone P,Hwang HY,Zemtseva I,Horvitz HR,Hirschberg CB

更新日期：2001-03-27 00:00:00

abstract：:The G protein-coupled m1 and m3 muscarinic acetylcholine receptors increase tyrosine phosphorylation of several proteins, including the focal adhesion-associated proteins paxillin and focal adhesion kinase (FAK), but the mechanism is not understood. Activation of integrins during adhesion of cells to extracellular mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slack BE

更新日期：1998-06-23 00:00:00

abstract：:Three genome-wide RNA interference screens were performed in Drosophila S2 cells to dissect the contribution of host processes to Listeria monocytogenes entry, vacuolar escape, and intracellular growth. Among the 116 genes identified, several host pathways previously unrecognized as playing a role in listerial pathoge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng LW,Viala JP,Stuurman N,Wiedemann U,Vale RD,Portnoy DA

更新日期：2005-09-20 00:00:00

abstract：:The members of the chimaerin family of Rac-GTPase-activating proteins possess a single C1 domain with high homology to those present in protein kinase C (PKC) isozymes. This domain in PKCs is involved in phorbol ester and diacylglycerol (DAG) binding. We previously have demonstrated that one of the chimaerin isoforms,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caloca MJ,Garcia-Bermejo ML,Blumberg PM,Lewin NE,Kremmer E,Mischak H,Wang S,Nacro K,Bienfait B,Marquez VE,Kazanietz MG

更新日期：1999-10-12 00:00:00

abstract：:The balance between cell survival and cell death is critical for normal lymphoid development. This balance is maintained by signals through lymphocyte antigen receptors and death receptors such as CD95/Fas. In some cells, ligating the B cell antigen receptor can protect the cell from apoptosis induced by CD95. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yankee TM,Draves KE,Ewings MK,Clark EA,Graves JD

更新日期：2001-06-05 00:00:00

abstract：:In this paper, we report the transcriptional organization of a 450-kb gene cluster in Xq28, flanked by the glucose-6-phosphate dehydrogenase and the color vision genes. CpG islands previously identified and mapped to distal Xq28 have helped in construction of a continuous contig of cosmids and in identification of cDN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bione S,Tamanini F,Maestrini E,Tribioli C,Poustka A,Torri G,Rivella S,Toniolo D

更新日期：1993-12-01 00:00:00

abstract：:CDK7 is a cyclin-dependent kinase proposed to function in two essential cellular processes: transcription and cell cycle regulation. CDK7 is the kinase subunit of the general transcription factor TFIIH that phosphorylates the C-terminal domain (CTD) of RNA polymerase II, and has been shown to be broadly required for t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallenfang MR,Seydoux G

更新日期：2002-04-16 00:00:00

abstract：:Reverse transcriptase (RNA-directed DNA polymerase, EC 2.7.7.49) of human immunodeficiency virus type 1 has been examined with respect to the steady-state kinetics of polymerization of dNTPs into product DNA. With dNTPs as variable substrate, the kinetics of polymerization deviated from standard Michaelis-Menten kinet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： West AB,Roberts TM,Kolodner RD

更新日期：1992-10-15 00:00:00

abstract：:A new type of self-assembling peptide (sapeptide) scaffolds that serve as substrates for neurite outgrowth and synapse formation is described. These peptide-based scaffolds are amenable to molecular design by using chemical or biotechnological syntheses. They can be tailored to a variety of applications. The sapeptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes TC,de Lacalle S,Su X,Liu G,Rich A,Zhang S

更新日期：2000-06-06 00:00:00

abstract：:Mitogen-stimulated scheduled DNA synthesis and DNA excision repair in human lymphocytes, as well as DNA polymerase a activity in a cell-free system, were inhibited by an electrophilic metabolite of benzo[a]pyrene. This metabolite, (+/-)-anti-(7r,8t)-dihydroxy-(9,10t)-epoxy-7,8,9,10-tetrahyd robenzo[a]pyrene (BPDE), co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busbee DL,Joe CO,Norman JO,Rankin PW

更新日期：1984-09-01 00:00:00

abstract：:Retinoic acid receptor beta (RAR beta), which codes for a nuclear receptor for retinoic acid, is localized in a chromosomal region frequently deleted in lung cancer cells. The gene is expressed in normal lung tissue and in the majority of the cell lines derived from lung tumors but not in most of the lines derived fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houle B,Rochette-Egly C,Bradley WE

更新日期：1993-02-01 00:00:00

abstract：:New approaches to the study of early hominin diets have refreshed interest in how and when our diets diverged from those of other African apes. A trend toward significant consumption of C4 foods in hominins after this divergence has emerged as a landmark event in human evolution, with direct evidence provided by stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wynn JG,Alemseged Z,Bobe R,Grine FE,Negash EW,Sponheimer M

更新日期：2020-09-08 00:00:00

abstract：:The role of geographic isolation in marine microbial speciation is hotly debated because of the high dispersal potential and large population sizes of planktonic microorganisms and the apparent lack of strong dispersal barriers in the open sea. Here, we show that gene flow between distant populations of the globally d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casteleyn G,Leliaert F,Backeljau T,Debeer AE,Kotaki Y,Rhodes L,Lundholm N,Sabbe K,Vyverman W

更新日期：2010-07-20 00:00:00

abstract：:Methane emissions due to accidents in the oil and natural gas sector are very challenging to monitor, and hence are seldom considered in emission inventories and reporting. One of the main reasons is the lack of measurements during such events. Here we report the detection of large methane emissions from a gas well bl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pandey S,Gautam R,Houweling S,Denier van der Gon H,Sadavarte P,Borsdorff T,Hasekamp O,Landgraf J,Tol P,van Kempen T,Hoogeveen R,van Hees R,Hamburg SP,Maasakkers JD,Aben I

更新日期：2019-12-16 00:00:00

abstract：:Aneuploidy, a chromosome content other than a multiple of the haploid number, is a common feature of cancer cells. Whole chromosomal aneuploidy accompanying ongoing chromosomal instability in mice resulting from reduced levels of the centromere-linked motor protein CENP-E has been reported to increase the incidence of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silk AD,Zasadil LM,Holland AJ,Vitre B,Cleveland DW,Weaver BA

更新日期：2013-10-29 00:00:00

abstract：:Protein-protein and protein-ligand interactions are ubiquitous in a biological cell. Here, we report a comprehensive study of the distribution of protein-ligand interaction sites, namely ligand-binding pockets, around protein-protein interfaces where protein-protein interactions occur. We inspected a representative se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao M,Skolnick J

更新日期：2012-03-06 00:00:00

abstract：:A hierarchy of residue density assessments and packing properties in protein structures are contrasted, including a regular density, a variety of charge densities, a hydrophobic density, a polar density, and an aromatic density. These densities are investigated by alternative distance measures and also at the interfac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baud F,Karlin S

更新日期：1999-10-26 00:00:00

abstract：:Direct conversion of carbon dioxide to multicarbon products remains as a grand challenge in electrochemical CO2 reduction. Various forms of oxidized copper have been demonstrated as electrocatalysts that still require large overpotentials. Here, we show that an ensemble of Cu nanoparticles (NPs) enables selective form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim D,Kley CS,Li Y,Yang P

更新日期：2017-10-03 00:00:00

abstract：:We have identified a major T-cell epitope, amino acids 48-54 (DRAHYNI, in one-letter code) in the E7 open reading frame protein of human papillomavirus (HPV) type 16. Lymph node cells from mice immunized with synthetic peptides containing DRAHYNI proliferated and produced interleukin when challenged in vitro with pept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tindle RW,Fernando GJ,Sterling JC,Frazer IH

更新日期：1991-07-01 00:00:00

abstract：:It is well-established morphologically that bipolar cells, the second-order neurons in the vertebrate retina, make reciprocal synapses with amacrine cells in the inner plexiform layer. However, neither the property nor the physiological function of the feedback synapse is understood. Autoradiographic and immunohistoch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tachibana M,Kaneko A

更新日期：1987-05-01 00:00:00

abstract：:The study of photoinitiated electron transfer in donor-bridge-acceptor molecules has helped elucidate the distance dependence of electron transfer rates and behavior of various electron transfer mechanisms. In all reported cases, the energies of the bridge electronic states involved in the electron transfer change dra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldsmith RH,Sinks LE,Kelley RF,Betzen LJ,Liu W,Weiss EA,Ratner MA,Wasielewski MR

更新日期：2005-03-08 00:00:00

abstract：:A cyclic AMP-binding protein (CAP protein), cyclic AMP, and RNA polymerase holoenzyme are shown to initiate lac transcription at the lac promoter. Lac repressor appears to control transcription by preventing RNA polymerase and/or CAP protein from binding to the lac promoter. Results support the idea that the lac promo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eron L,Block R

更新日期：1971-08-01 00:00:00

abstract：:A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects that are subject to cultural selection. However, evidence for such selection is inconclusive because it is based on short-term statistical associations between behavior and ferti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansing JS,Watkins JC,Hallmark B,Cox MP,Karafet TM,Sudoyo H,Hammer MF

更新日期：2008-08-19 00:00:00

abstract：:The present paper summarizes future needs in information and tools, technology, infrastructure, training, funding, and bioinformatics, to provide the genomic knowledge and tools for breeding and biotechnological goals in maize. The National Corn Genome Initiative (NCGA) has developed through actions taken by the Natio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coe EH

更新日期：1998-03-03 00:00:00

abstract：:The complete amino acid and DNA sequences of the human 40-kDa keratin are reported. The DNA sequence encodes a protein of 44,098 Da, which is unique in that it lacks the terminal non-alpha-helical tail segment found in all other keratins. When the human 40-kDa keratin amino acid sequence is compared to the correspondi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eckert RL

更新日期：1988-02-01 00:00:00

abstract：:Previous research has implicated a large network of brain regions in the processing of risk during decision making. However, it has not yet been determined if activity in these regions is predictive of choices on future risky decisions. Here, we examined functional MRI data from a large sample of healthy subjects perf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helfinstein SM,Schonberg T,Congdon E,Karlsgodt KH,Mumford JA,Sabb FW,Cannon TD,London ED,Bilder RM,Poldrack RA

更新日期：2014-02-18 00:00:00