Abstract:
:To investigate arthritis-inducing properties of Eubacterium species, which are major residents of the human intestinal flora, cell wall fragments (CWF) of several Eubacterium strains were prepared and tested in an animal model. After a single intraperitoneal injection in the rat, CWF of E. aerofaciens, E. contortum, and E. lentum induced a chronic polyarthritis. E. limosum and E. tortuosum CWF induced an acute self-limiting joint inflammation, whereas E. rectale CWF failed to do so. The rhamnose contents of the isolated CWF were not related to their arthritis-inducing properties. Paradoxically, the sensitivity of CWF to lysozyme digestion, which is regarded as a parameter for the clearance of CWF in tissues, appeared to be positively correlated with the ability of Eubacterium CWF to induce chronic joint inflammation. Our findings show the diversity in arthritis-inducing properties among different species of the anaerobic genus Eubacterium and underline the importance of the anaerobic intestinal flora in the induction of joint inflammation.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Severijnen AJ,van Kleef R,Hazenberg MP,van de Merwe JPdoi
10.1128/IAI.58.2.523-528.1990subject
Has Abstractpub_date
1990-02-01 00:00:00pages
523-8issue
2eissn
0019-9567issn
1098-5522journal_volume
58pub_type
杂志文章abstract::Pneumonic plague, caused by inhalation of Yersinia pestis, represents a major bioterrorism threat for which no vaccine is available. Based on the knowledge that genetic delivery of monoclonal antibodies (MAbs) with adenovirus (Ad) gene transfer vectors results in rapid, high-level antibody expression, we evaluated the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00856-08
更新日期:2009-04-01 00:00:00
abstract::It is not clear how the host initially recognizes and responds to infection by gram-negative pathogenic Brucella spp. It was previously shown (D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky, J. Immunol. 172:4463-4469, 2004) that the early macrophage response against gram-negative bacteria is mediated ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.8.5137-5143.2005
更新日期:2005-08-01 00:00:00
abstract::Vibrio vulnificus causes rapidly progressing septicemia with an extremely high mortality rate (≥50%), even with aggressive antibiotic treatment. The bacteria secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins, which are involved in the pathogenesis of Gram-negative Vibrio species. Recently, we repo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02130-14
更新日期:2014-11-01 00:00:00
abstract::Cholera is an acute diarrheal disease that is caused by the gram-negative bacterium Vibrio cholerae. The low efficacy of currently available killed-whole-cell vaccines and the reactinogenicity coupled with potential reversion of live vaccines have thus far precluded widespread vaccination for the control of cholera. R...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7695-7702.2001
更新日期:2001-12-01 00:00:00
abstract::Streptococcus equi and Streptococcus zooepidemicus are major etiological agents of upper and lower airway disease in horses. Despite the considerable animal suffering and economic burden associated with these diseases, the factors that contribute to the virulence of these equine pathogens have not been extensively inv...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.10.6048-6051.2000
更新日期:2000-10-01 00:00:00
abstract::The role of the alternative sigma factor sigma(B) in Staphylococcus epidermidis was investigated by the construction, complementation, and characterization of a sigB deletion mutant. Electrophoretic analyses confirmed a profound influence of sigma(B) on the expression of exoproteins and cytoplasmic proteins. Detailed ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.12.7933-7936.2001
更新日期:2001-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.3.1440-1443.2001
更新日期:2001-03-01 00:00:00
abstract::While the pathological events evoked by infection are commonly described, effective host responses to bacteria and their products should primarily be protective. Heat shock protein (Hsp) expression is upregulated by many stimuli and serves to maintain intracellular protein integrity. The ability of the prototypic supe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.6.3187-3194.2004
更新日期:2004-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.7.2605-2611.1992
更新日期:1992-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.1.295-302.1993
更新日期:1993-01-01 00:00:00
abstract::Neutrophils are the first cells to infiltrate to the site of Leishmania promastigote infection, and these cells help to reduce parasite burden shortly after infection is initiated. Several clinical reports indicate that neutrophil recruitment is sustained over the course of leishmaniasis, and amastigote-laden neutroph...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00770-13
更新日期:2013-11-01 00:00:00
abstract::Enteropathogenic strains of Yersinia enterocolitica harbor a virulence plasmid (70 kilobases) which specifies, at 37 degrees C, a calcium requirement for growth, autoagglutinability, resistance to the bactericidal activity of human serum, and the expression of some outer membrane proteins (OMPs). To map the genes enco...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.3.782-786.1985
更新日期:1985-06-01 00:00:00
abstract::Citrobacter rodentium is an attaching and effacing pathogen which causes transmissible colonic hyperplasia in mice. Infection with C. rodentium serves as a model for infection of humans with enteropathogenic and enterohemorrhagic Escherichia coli. To identify novel colonization factors of C. rodentium, we screened a s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00770-08
更新日期:2008-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.3.657-663.1986
更新日期:1986-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.7.3822-3829.2000
更新日期:2000-07-01 00:00:00
abstract::Ureaplasma urealyticum is a common commensal of the female lower urogenital tract, yet it has been shown to be an important cause of chorioamnion infection, respiratory and central nervous system disease, and death in premature infants. It has been suggested that only certain serovars are capable of producing invasive...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.3.891-898.1995
更新日期:1995-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.10.5994-6003.2003
更新日期:2003-10-01 00:00:00
abstract::The ability of Toxoplasma gondii tachyzoites to differentiate into latent bradyzoite forms is essential for pathogenesis of clinical disease. We examined the effects of cyclic nucleotides on T. gondii bradyzoite differentiation in vitro. Differentiation of tachyzoites to bradyzoites was measured in an immunofluorescen...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.1.148-153.2001
更新日期:2001-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.2.424-431.1988
更新日期:1988-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.8.2983-2988.1995
更新日期:1995-08-01 00:00:00
abstract::One of the chromosomal segments associated with the virulence of Shigella flexneri and transferred to Escherichia coli K-12 by conjugation has been shown to code for the production of aerobactin and for the synthesis of an iron-regulated 76,000-dalton (76K) outer membrane protein. Analysis of various E. coli K-12-S. f...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.1.67-71.1985
更新日期:1985-07-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.8.4955-4959.2005
更新日期:2005-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.8.4256-4259.1999
更新日期:1999-08-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.12.5491-5497.1994
更新日期:1994-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.11.6582-6590.2003
更新日期:2003-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.8.3117-3121.1992
更新日期:1992-08-01 00:00:00
abstract::To assess the humoral immunological responses at the subclass level in shigellosis, specific antibody responses against Shigella dysenteriae 1 lipopolysaccharide (LPS), S. flexneri Y LPS, invasion plasmid-coded protein antigens (Ipa), and Shiga toxin were analyzed. Antibody responses of 41 patients with S. dysenteriae...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.5.2054-2061.1995
更新日期:1995-05-01 00:00:00
abstract::A gene library of Chlamydia trachomatis (serovar L1) DNA has been prepared in the phage vector lambda 1059. From this bank, 20 recombinant phage-expressing components which reacted with serum from a patient with a C. trachomatis (L1) infection were chosen. Selective expression and radiolabeling of phage polypeptides i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.3.637-641.1984
更新日期:1984-09-01 00:00:00
abstract::Studies concerned with the mechanisms responsible for relative resistance or susceptibility of strains of inbred mice to Trypanosoma musculi infections are presented. Treatment with 400 rads of ionizing radiation, silica dust, or trypan blue (reticuloendothelial blocking agents) rendered C3H mice unable to control the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.6.1647-1655.1989
更新日期:1989-06-01 00:00:00
abstract::In vitro, macrophages from normal strain BRVR mice killed Salmonella more quickly than did macrophages from normal strain BSVS mice. Salmonella injected intraperitoneally multiplied more quickly in BSVS mice than in BRVR mice. BRVR macrophages injected intraperitoneally into BSVS mice protected against Salmonella mult...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.6.4.438-443.1972
更新日期:1972-10-01 00:00:00