Abstract：
:This ISAAC Phase Three synthesis provides summarised information on the main findings of the study, regional tables and figures related to the prevalence and severity of current symptoms of asthma, rhinoconjunctivitis and eczema in the main regions of the world. The large number of surveyed children (≈1,200,000), the large number of centres (233) and countries (98) that participated in ISAAC Phase Three makes this study the most comprehensive survey of these diseases ever undertaken. Globally, the prevalence for current asthma, rhinoconjunctivitis and eczema in the 13-14-year age group was 14.1%, 14.6% and 7.3%, respectively. In the 6-7-year age group the prevalence for current asthma, rhinoconjunctivitis and eczema was 11.7%, 8.5% and 7.9%, respectively. The study shows a wide variability in the prevalence and severity of asthma, rhinoconjunctivitis and eczema which occurs not just between regions and countries but between centres in the same country and centres in the same city. This study definitively establishes that the prevalence of those diseases can be very high in non-affluent centres with low socioeconomic conditions. The large variability also suggests a crucial role of local environment characteristics to determine the differences in prevalence between one place and another. Thus, ISAAC Phase Three has provided a large body of epidemiological information on asthma, rhinoconjunctivitis and eczema in childhood from contrasting environments which is expected to yield new clues about the aetiology of those conditions and reasons for their marked global variability.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Mallol J,Crane J,von Mutius E,Odhiambo J,Keil U,Stewart A,ISAAC Phase Three Study Group.doi
10.1016/j.aller.2012.03.001subject
Has Abstractpub_date
2013-03-01 00:00:00pages
73-85issue
2eissn
0301-0546issn
1578-1267pii
S0301-0546(12)00109-7journal_volume
41pub_type
杂志文章,多中心研究abstract：BACKGROUND:The clinical relevance of elevated basal serum tryptase (eBST ≥ 11.4 ng/ml) often remains unclear. METHODS:BST was assessed in 15,298 patients attending our outpatient clinic. Frequency and severity of anaphylaxis was compared in 900 patients with eBST and 900 patients with normal BST. The prevalence of eBS...
journal_title：Allergologia et immunopathologia
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更新日期：2014-11-01 00:00:00
abstract：:We studied a group of asthmatic patients with aspirin intolerance who were RAST-negative for house-dust and Dermatophagoides-pteronyssinus despite having positive skin tests and positive inhalation tests to these allergens. Total haemolytic activity (CH50), C3, C4 and C3PA were measured after allergen-induced bronchos...
journal_title：Allergologia et immunopathologia
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doi：
更新日期：1983-11-01 00:00:00
abstract：BACKGROUND:Occupational allergy among florists and people who work in cut flower production of Alstroemeria cultivars (Peruvian lily or Inca lily) has been previously reported. The allergen involved in sensitization is tulipalin A (alpha-methylene-gamma-butyrolactone). CASE REPORT:We describe the case of a 65-year-old...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13086751
更新日期：2006-03-01 00:00:00
abstract：:It has recently been published patients suffering from urticaria or anaphylaxia induced by nematodes usually parasitizing fishs or cephalopode, in whom, Anisakis simplex (AK) sensitization prevalence was detected up to 37%. We tried out a prospective study to evaluate the presence of AK specific-IgE in an asthmatic po...
journal_title：Allergologia et immunopathologia
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更新日期：1997-03-01 00:00:00
abstract：BACKGROUND:Some studies indicate some causal relationship between obesity and asthma, while others show inconsistent results. Our objective was to evaluate the prevalence of asthma according to obesity in children. METHODS:A cross-sectional study, following the ISAAC study methodology, was conducted on two randomly se...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.aller.2012.05.011
更新日期：2013-05-01 00:00:00
abstract：:Specific immunotherapy consists of the administration of allergen extracts to patients with allergic disease to achieve clinical tolerance to the causative allergens. Currently, it is the only etiologic treatment for respiratory allergy. A World Health Organization opinion paper published in 1997 defines immunotherapy...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
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更新日期：2004-05-01 00:00:00
abstract：:Common variable immunodeficiency is a disorder characterised by hypogammaglobulinemia with B-lymphocytes in peripheral blood and repeated infections. We report a child with a diagnosis of diabetes mellitus and celiac disease during lactation, and in whom common variable immunodeficiency was diagnosed at the age of 5. ...
journal_title：Allergologia et immunopathologia
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更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Although it has been hypothesized that infections may play a preventive role in allergic diseases, the role of Helicobacter pylori (H. pylori) is not clear. In this study we aimed to determine the association between H. pylori infection and allergic inflammation. METHODS:H. pylori infection was assessed in ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1157/13120393
更新日期：2008-03-01 00:00:00
abstract：:A retrospective study on 52,900 individuals tested in 177 Italian Medical Centres for AIDS and related syndromes is reported. The data confirm that I.V. drug users are the group at highest risk in Italy (46% were seropositive and more than one half of these presented PGL or ARC) and that the epidemic probably started ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Anaphylaxis is a sudden, severe, and potentially life-threatening allergic reaction, affecting a portion of allergic patients. Adrenaline is the first-line medication for anaphylaxis and available in many parts of the world as adrenaline autoinjectors (AAIs). OBJECTIVE:Aim of this study was to determine att...
journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2013.01.007
更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.aller.2018.07.010
更新日期：2019-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.aller.2012.05.005
更新日期：2013-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1978-07-01 00:00:00
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更新日期：2006-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2018.07.005
更新日期：2019-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
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更新日期：1982-05-01 00:00:00
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更新日期：2017-01-01 00:00:00
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更新日期：2015-03-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1993-09-01 00:00:00
abstract：:Clinical characteristics of allergic asthma due to inhalation of insect antigens have been investigated very little. We describe two patients presenting with dyspnoea and wheezing several hours after exposure to larvae of Calliphora erythrocephala used as fishing bait. Both patients had a positive intradermal skin tes...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
