Catabolite repression control of pyocyanin biosynthesis at an intersection of primary and secondary metabolism in Pseudomonas aeruginosa.

Abstract:

:In Pseudomonas aeruginosa, the catabolite repression control (Crc) protein repressed the formation of the blue pigment pyocyanin in response to a preferred carbon source (succinate) by interacting with phzM mRNA, which encodes a key enzyme in pyocyanin biosynthesis. Crc bound to an extended imperfect recognition sequence that was interrupted by the AUG translation initiation codon.

journal_name

Appl Environ Microbiol

authors

Huang J,Sonnleitner E,Ren B,Xu Y,Haas D

doi

10.1128/AEM.00026-12

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

5016-20

issue

14

eissn

0099-2240

issn

1098-5336

pii

AEM.00026-12

journal_volume

78

pub_type

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