The prognostic significance of early stage lymph node positivity in operable invasive breast carcinoma: number or stage.

abstract：:Plasma diamine oxidase levels were assayed in 66 patients who presented with pregnancy complicated by threatened abortion. Levels within the normal range were associated with continuing pregnancies, whereas levels below the normal range were associated with subsequent abortion. Among those patients in whom gestation w...

journal_title：Journal of clinical pathology

authors： Legge M,Duff GB

更新日期：1981-02-01 00:00:00

abstract：:A patient with hyperparathyroidism due to a parathyroid adenoma was found to have metastatic medullary carcinoma in lymph nodes close to the thyroid gland. The finding of normal calcitonin and parathormone concentrations after removal of the adenoma suggested that the parathyroid lesion was not the result of the hypoc...

journal_title：Journal of clinical pathology

authors： MacGillivray JB,Anderson CJ

更新日期：1971-12-01 00:00:00

abstract：:A case is described in which marked hepatic fibrosis probably resulted from the prolonged treatment of acute leukaemia with methotrexate. ...

journal_title：Journal of clinical pathology

authors： Talerman A,Thompson RB

更新日期：1966-01-01 00:00:00

abstract：:An influenza virus vaccine containing the purified surface haemagglutinin and neuraminidase antigens of A/Victoria/75 and B/Hong Kong/73 viruses adsorbed to an aluminium hydroxide gel was assessed for reactogenicity and immunogenicity in children aged 4 to 11 years, since there is no influenza virus vaccine available ...

journal_title：Journal of clinical pathology

authors： Eastwood LM,Jennings R,Milner RD,Potter CW

更新日期：1979-06-01 00:00:00

abstract：:Hereditary spherocytosis is a relatively common haematological disorder and will be encountered by all haematologists. The abundance of new information, dealing principally with molecular and genetic aspects of pathophysiology, is beginning to have implications for its investigation and management. While these advance...

journal_title：Journal of clinical pathology

authors： Smedley JC,Bellingham AJ

更新日期：1991-06-01 00:00:00

abstract：:Antithrombin activities in 30 severely malnourished children and 40 normal children were estimated in clotting tests by thrombin neutralisation as anti-Xa and by a heparin antithrombin assay; and by immunodiffusion as alpha 2-globulin and alpha 1-antitrypsin. The patients' mean alpha 2-globulin was severely depressed,...

journal_title：Journal of clinical pathology

authors： Jiménez RA,Jiménez E,Ingram GI,Mora LA,Atmetlla F,Carrillo JM,Vargas W

更新日期：1979-10-01 00:00:00

abstract：AIMS:To determine how epithelial and stromal thymidine phosphorylase expression affects angiogenesis, rapid tumour growth, and decreased apoptotic activity in cervical cancer at varying stages of progression. METHODS:Epithelial and stromal thymidine phosphorylase expression, the microvessel count (reflected by factor ...

journal_title：Journal of clinical pathology

authors： Fujiwaki R,Hata K,Iida K,Maede Y,Koike M,Miyazaki K

更新日期：1999-08-01 00:00:00

abstract：:The assessment of emphysema in human lungs has traditionally been based on observations made on whole lung slices. These methods are inappropriate for the study of early emphysema, because as much as 75% of the alveolar wall surface area may have been lost by the time airspaces are visible to the naked eye. A new, aut...

journal_title：Journal of clinical pathology

authors： Gillooly M,Lamb D,Farrow AS

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancers (TNBCs) are defined by their lack of oestrogen receptor, progesterone receptor and epidermal growth factor receptor 2. Although heterogeneous, the majority are aggressive and treatment options are limited. Caveolin acts as tumour suppressor or promoter depending on the cancer t...

journal_title：Journal of clinical pathology

authors： Yeong J,Thike AA,Ikeda M,Lim JCT,Lee B,Nakamura S,Iqbal J,Tan PH

更新日期：2018-02-01 00:00:00

abstract：:Apoptosis can be induced in response to hypoxia. The severity of hypoxia determines whether cells become apoptotic or adapt to hypoxia and survive. A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic. Apoptosis regulatory proteins are delicately b...

journal_title：Journal of clinical pathology

authors： Greijer AE,van der Wall E

更新日期：2004-10-01 00:00:00

abstract：:Thirteen unrelated patients with idiopathic haemochromatosis (eight men, five women) were studied. The diagnosis was based on clinical, biological, and histochemical findings. HLA typing was performed in all 13 and in all of their available first degree relatives (n = 31). HLA A3 was present in nine of 13 probands (69...

journal_title：Journal of clinical pathology

authors： Czìnk E,Gyódi EK,Német K,Hollán S

更新日期：1991-01-01 00:00:00

abstract：:Improvements in the Zimmermann reaction are effected by using methanol as a solvent for the reagents employed in the reaction in place of ethanol or aqueous ethanol. The advantages are as follows. Considerably lower blanks are obtained; extraneous chromogens are negligible at the wavelength of measurement, so that no ...

journal_title：Journal of clinical pathology

authors： BEALE RN,BOSTROM JO,CROFT D

更新日期：1962-11-01 00:00:00

abstract：:A severe non-dose related skin eruption attributable to treatment with captopril was recently reported: this is distinct from the dose related rashes that have been widely described. Ultrastructural and immunohistochemical studies were carried out to determine in detail the histological features of this eruption: the ...

journal_title：Journal of clinical pathology

authors： Furness PN,Goodfield MJ,MacLennan KA,Stevens A,Millard LG

更新日期：1986-08-01 00:00:00

abstract：:An enzyme linked immunosorbent assay (ELISA) to measure free serum IgG antibodies to Pseudomonas aeruginosa in patients with cystic fibrosis was developed. Seven strains of P aeruginosa cells, treated with glutaraldehyde and representing the most commonly isolated serotypes in our cystic fibrosis unit, were used. The ...

journal_title：Journal of clinical pathology

authors： Brett MM,Ghoneim AT,Littlewood JM,Losowsky MS

更新日期：1986-10-01 00:00:00

abstract：AIM:Definitive distinction between low-grade astrocytoma and astrogliosis is a long-standing difficulty due to their similar histopathological characteristics. To clarify differences in biological significance, this study focused on various components of the cell cycle machinery and proliferation as key parameters, com...

journal_title：Journal of clinical pathology

authors： Hara A,Saegusa M,Ichinoe M,Okayasu I

更新日期：2008-03-01 00:00:00

abstract：:Human and chicken blood were snap-frozen as droplets in liquid ntirogen. Storage in the vapour phase liquid nitrogen container for nine months followed by rapid thawing resulted in approximately 10% haemolysis of the red cells. The ability of the thawed red cells to haemagglutinate viruses was unimpaired by the manipu...

journal_title：Journal of clinical pathology

authors： Rodgers FG

更新日期：1980-01-01 00:00:00

abstract：AIMS:To determine whether the monoclonal antibody (MoAb) 83D4, previously shown to be highly specific for carcinoma cells, can be used as an immunocytological marker to discriminate between benign and malignant cells in serous effusions; and to test for a correlation between expression of the antigen reacting with MoAb...

journal_title：Journal of clinical pathology

authors： Beuzelin-Yvraut M,Bourguignat A,Phillips E,Roseto A,Osinaga E

更新日期：1995-05-01 00:00:00

abstract：:Pseudolipoma of the liver is a rare condition which may be confused with metastatic tumours, primary tumours, or other lesions of the liver. This study presents three hepatic pseudolipomas that occurred in men aged 33, 38, and 42 years. The prevalence of hepatic pseudolipomas was 0.2% in a series of 1300 consecutive n...

journal_title：Journal of clinical pathology

authors： Karhunen PJ

更新日期：1985-08-01 00:00:00

abstract：:The case records and pathology of all children with kidney tumours treated in the West Midlands Health Authority Region (WMHAR) from 1957 to 1986 were reviewed. The histology was reviewed by a panel of three paediatric pathologists. Thirteen (6%) out of 211 cases were considered to have congenital mesoblastic nephroma...

journal_title：Journal of clinical pathology

authors： Barrantes JC,Toyn C,Muir KR,Parkes SE,Raafat F,Cameron AH,Marsden HB,Mann JR

更新日期：1991-04-01 00:00:00

abstract：:The technique devised by Moore (1960) for determining the sensitivity of staphylococci to mercuric chloride was investigated and the effect of variations in the medium determined. An alternative technique, in which paper discs impregnated with phenyl mercuric nitrate are used, was found to give identical results. Thre...

journal_title：Journal of clinical pathology

authors： GREEN SM

更新日期：1962-05-01 00:00:00

abstract：:A method for the simultaneous labelling of terminal deoxynucleotidyl transferase (TdT) and membrane antigens is described. TdT is visualised in the cell nucleus with the peroxidase-antiperoxidase (PAP) method, and the immunogold method is used in combination with monoclonal antibodies against membrane antigens. The mo...

journal_title：Journal of clinical pathology

authors： Tavares de Castro J,San Miguel JF,Soler J,Catovsky D

更新日期：1984-06-01 00:00:00

abstract：:The potencies of six commercially manufactured heparins have been measured by the British Pharmacopoeial (BP) assay and activated partial thromboplastin time (APTT), protamine sulphate, and anti-Xa assays. The APTT/BP potency ratios were found to vary with the preparation but this was not dependent on the tissue sourc...

journal_title：Journal of clinical pathology

authors： Shah GA,Dhall TZ,Ferguson I,Davis MR,Graham DT,Pomeroy AR,Dhall DP

更新日期：1980-06-01 00:00:00

abstract：:Nasal biopsy findings in malignant histiocytosis presenting clinically as lethal midline granuloma are characterised by necrosis and infiltration of atypical histiocytic cells with a diffuse positive reaction for non-specific esterase. This cellular character was common to midline malignant reticulosis, and midline ma...

journal_title：Journal of clinical pathology

authors： Aozasa K

更新日期：1982-06-01 00:00:00

abstract：AIM:To investigate the natural history of patients with non-alcoholic steatohepatitis by means of a prospective histological study. METHODS:One thousand five hundred and seventy one patients underwent liver biopsy at the Western Infirmary in Glasgow during the 10 year period 1985 to 1994. All biopsies were reported by...

journal_title：Journal of clinical pathology

authors： Evans CD,Oien KA,MacSween RN,Mills PR

更新日期：2002-09-01 00:00:00

abstract：:The nitroblue tetrazolium (NBT) test has been evaluated as a means of differentiating episodes of infection and rejection in 10 cadaver kidney transplant recipients. Normal NBT values were observed during all 11 episodes of acute rejection. A significant elevation of the NBT score was encountered in six of eight episo...

journal_title：Journal of clinical pathology

authors： Gordon AM,Briggs JD,Bell PR

更新日期：1974-09-01 00:00:00

abstract：BACKGROUND:Nitric oxide synthase (NOS), particularly endothelial and inducible forms (e/i-NOS), are expressed in various cancers, including breast cancer. In mammary fibroepithelial lesions, NOS expression in stromal cells has been reported to be lower in fibroadenomas than in phyllodes tumours. AIMS:To investigate NO...

journal_title：Journal of clinical pathology

authors： Tse GM,Wong FC,Tsang AK,Lee CS,Lui PC,Lo AW,Law BK,Scolyer RA,Karim RZ,Putti TC

更新日期：2005-06-01 00:00:00

abstract：:The sellar region is the site of a large number of pathological entities arising from the pituitary and adjacent anatomical structures, including brain, blood vessels, nerves and meninges. The surgical pathology of this area requires the accurate identification of neoplastic lesions, including pituitary adenoma and ca...

journal_title：Journal of clinical pathology

authors： Al-Brahim NY,Asa SL

更新日期：2006-12-01 00:00:00

abstract：:In four persons of one family the existence of an enzymatic defect, presumably consisting of a deficiency of glutaminase in the cells of the renal tubules, is postulated, and is implied by a reduced elimination of ammonia in the urine, by a relatively low urinary pH, and by its increased titratable acidity. The most c...

journal_title：Journal of clinical pathology

authors： KRAWCZYNSKI J,SAGAN Z,WALAJTYS E,ILOWIECKA K

更新日期：1965-03-01 00:00:00

abstract：:The ability of erythrocytes to synthesize porphyrins from delta-aminolaevulic acid was compared in healthy people, patients with true iron-deficiency anaemia, and anaemic patients with rheumatoid arthritis. Porphyrin synthesis was found to be impaired in true iron deficiency but not in rheumatoid arthritis cases showi...

journal_title：Journal of clinical pathology

authors： Gutniak O,Kopéc M,Nieczaj J

更新日期：1971-05-01 00:00:00

abstract：:A rapid and reproducible technique for in situ hybridisation, using biotin labelled probes for the Y chromosome, human DNA, hepatitis B virus DNA and cytomegalovirus DNA on formalin fixed, paraffin embedded liver tissue, was developed. The degree of proteolytic digestion of tissue specimens is critical to ensure adequ...

journal_title：Journal of clinical pathology

authors： Naoumov NV,Alexander GJ,Eddleston AL,Williams R

更新日期：1988-07-01 00:00:00