Abstract:
PURPOSE OF REVIEW:The present review updates current findings on long-term clinical and immunological outcomes after cessation of allergen immunotherapy for allergic respiratory disease. RECENT FINDINGS:Recent studies have shown that allergen immunotherapy has sustained disease-modifying effects that persist for years after discontinuation. This is in contrast to the effects of antiallergic drugs that do not induce tolerance to offending allergens. Long-term effects of immunotherapy include a reduction in nasal symptoms, a decrease in the use of rescue medication and improvement in quality of life. These benefits are accompanied by immunological changes such as the induction of allergen-specific IgG antibodies with inhibitory activity for IgE-facilitated binding of allergen-IgE complexes to B cells. One study reported a reduction in the development of asthma in children with seasonal pollen-induced rhinitis. SUMMARY:Allergen immunotherapy induces clinical and immunological tolerance as defined by persistence of clinical benefit and associated long-term immunological parameters after discontinuation of treatment. These findings are largely confined to studies of subcutaneous and sublingual immunotherapy for seasonal pollinosis. Further studies are needed to address potential long-term clinical effects for other seasonal and perennial inhaled allergens in both children and adults, and to identify potential biomarkers of tolerance.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Eifan AO,Shamji MH,Durham SRdoi
10.1097/ACI.0b013e32834cb994subject
Has Abstractpub_date
2011-12-01 00:00:00pages
586-93issue
6eissn
1528-4050issn
1473-6322journal_volume
11pub_type
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2004-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2001-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2011-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000612
更新日期:2020-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283489bc3
更新日期:2011-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000204
更新日期:2015-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Key aspects and outcomes from the recently published guidance on the regulation of allergen products are summarized. RECENT FINDINGS:A new regulatory guideline has been published to enhance harmonized national approaches on the regulation of allergen products and thereby strengthen the availability o...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000687
更新日期:2020-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Complementary medicines, including acupuncture and Chinese herbal medicine, are being used increasingly for the management of allergies such as allergic rhinitis. Until relatively recently, however, evidence for the efficacy and safety of these therapies in allergic conditions has been lacking. RECEN...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000225156.29780.36
更新日期:2006-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200308000-00006
更新日期:2003-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The main feature of allergen-specific immunotherapy is its capacity to modify the natural history of the disease, reducing the development of asthma and new sensitizations after 3-4 years of treatment. For this reason, adherence to the therapy is mandatory, as happens for all chronic medical treatment...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328332b8df
更新日期:2009-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200402000-00011
更新日期:2004-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2007-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328357b4a2
更新日期:2012-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283630cc2
更新日期:2013-08-01 00:00:00