Toxic epidermal necrolysis: the year in review.

abstract：PURPOSE OF REVIEW:Key aspects and outcomes from the recently published guidance on the regulation of allergen products are summarized. RECENT FINDINGS:A new regulatory guideline has been published to enhance harmonized national approaches on the regulation of allergen products and thereby strengthen the availability o...

journal_title：Current opinion in allergy and clinical immunology

authors： Bonertz A,Mahler V,Vieths S

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin D deficiency has been rediscovered as a public-health problem worldwide. It has been postulated that vitamin D deficiency may explain a portion of the asthma epidemic. The purpose of this review is to present the evidence for a role of vitamin D in asthma. RECENT FINDINGS:Both animal models a...

journal_title：Current opinion in allergy and clinical immunology

authors： Litonjua AA

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Although today's cornerstone therapies for asthma (inhaled bronchodilators and corticosteroids) target airway narrowing and lung inflammation, about half of treated asthmatic patients do not achieve good disease control. There is a clear need for new therapeutic approaches and novel drug targets. Rece...

journal_title：Current opinion in allergy and clinical immunology

authors： Grassin-Delyle S,Naline E,Devillier P

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Vernal keratoconjunctivitis (VKC) is a rare chronic self-limiting allergic inflammatory disease of the ocular surface mostly affecting young boys in their first decade of life. In the last few years a new clinical entity of VKC has been described: adult VKC. Two variants have been identified according...

journal_title：Current opinion in allergy and clinical immunology

authors： Di Zazzo A,Bonini S,Fernandes M

更新日期：2020-10-01 00:00:00

abstract：:This review summarizes recent advances and findings in the area of 'hidden' food allergens, i.e. allergenic foods that can either contaminate other foods, or be 'disguised' as part of a food, and cause allergic reactions. Newly emerging allergenic foods of increasing importance, recently developed methods for the dete...

journal_title：Current opinion in allergy and clinical immunology

authors： Hefle SL

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is a fatal syndrome of overwhelming autoimmunity. Recent identification of FOXP3 as the causative gene and realization that this same gene defect occurs in the mutant mouse Scurfy has yielded new insights and hopes of unraveling ...

journal_title：Current opinion in allergy and clinical immunology

authors： Torgerson TR,Ochs HD

更新日期：2002-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the immunology of chronic beryllium disease. It addresses the importance of the interaction between class II molecules and the T cells that recognize beryllium, along with the subsequent immune response that results in sensitization and disease, and genetic factors leading to var...

journal_title：Current opinion in allergy and clinical immunology

authors： Samuel G,Maier LA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to describe the impact of asthma treatment non-adherence on patients and the healthcare system, and to outline areas of responsibility towards improved adherence. RECENT FINDINGS:The average cost of healthcare expenses for each person in the United States in 2002 was 544...

journal_title：Current opinion in allergy and clinical immunology

authors： Bender BG,Rand C

更新日期：2004-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Secondhand smoke (SHS) exposure in the workplace remains common and has important acute and chronic health effects. The present study reviews the recent evidence linking workplace SHS exposure with poor health and the benefits of smoke-free workplace legislation. RECENT FINDINGS:Workplace SHS exposur...

journal_title：Current opinion in allergy and clinical immunology

authors： Eisner MD

更新日期：2010-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe recent insight into the efficacy of intranasal corticosteroids in treating ocular signs and symptoms of allergic rhinoconjunctivitis. RECENT FINDINGS:The efficacy of intranasal corticosteroids in treating allergic nasal symptoms is well established, and recent evidence indicates that this...

journal_title：Current opinion in allergy and clinical immunology

authors： Origlieri C,Bielory L

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Personalized medicine encompasses the use of biological information such as genomics to provide tailored interventions for patients. The review explores the ethical, legal, and social issues that have emerged with personalized medicine and must be considered because of the complex nature of providing ...

journal_title：Current opinion in allergy and clinical immunology

authors： Joly Y,Saulnier KM,Osien G,Knoppers BM

更新日期：2014-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Cow's milk allergy affects 2-3% of young children, the economic impact of which necessitates search for simple diagnostic tools and affordable milk substitutes. This review examines recent studies on the diagnosis of cow's milk allergy as well as on the allergenicity of milk from other mammalian speci...

journal_title：Current opinion in allergy and clinical immunology

authors： Järvinen KM,Chatchatee P

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Indoor pollutants and allergens cause asthma symptoms and exacerbations and influence the risk of developing asthma. We review recent studies regarding the effects of the indoor environment on childhood asthma. RECENT FINDINGS:Exposure to some indoor allergens and second hand smoke are causally relat...

journal_title：Current opinion in allergy and clinical immunology

authors： Ahluwalia SK,Matsui EC

更新日期：2011-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The autoimmune lymphoproliferative syndrome is a recently identified human disorder of lymphocyte apoptosis that has provided important information about Fas-mediated lymphocyte apoptosis. In this review we summarize current information regarding the diagnosis, management and underlying molecular basi...

journal_title：Current opinion in allergy and clinical immunology

authors： Oliveira JB,Fleisher T

更新日期：2004-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The current EAACI/GA²LEN/EDF/WAO treatment guidelines for the management of urticaria recommend omalizumab as fourth-line therapy. Within the last year, many reports of omalizumab treatment in chronic urticaria have been published. RECENT FINDINGS:Two multicenter, randomized, placebo-controlled trial...

journal_title：Current opinion in allergy and clinical immunology

authors： Metz M,Maurer M

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Eosinophil granulocyte myeloid cells are increased in atopic and nonatopic rhinitis, chronic rhinosinusitis (CRS) and atopic keratoconjunctivitis, diseases of the upper respiratory tract. Eosinophils contain several basic granule proteins, the best known being the eosinophil cationic protein (ECP). EC...

journal_title：Current opinion in allergy and clinical immunology

authors： Bystrom J,Patel SY,Amin K,Bishop-Bailey D

更新日期：2012-02-01 00:00:00

abstract：:Asthma is a disease that is, in large part, defined by abnormalities of pulmonary function. Failure of any new treatment modality to improve objective measures of lung function suggests a limited usefulness of such new therapies. The clear dissociation between inflammation and airways responsiveness indicates the latt...

journal_title：Current opinion in allergy and clinical immunology

authors： Kaminsky DA,Irvin CG

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to compare and contrast the newer inhaled corticosteroid (ICS) ciclesonide with older ICSs in terms of pharmacodynamic and pharmacokinetic properties and how these affect comparative efficacy. In addition, clinical dosing strategies for ICSs including as-needed use will b...

journal_title：Current opinion in allergy and clinical immunology

authors： Stoloff SW,Kelly HW

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Technological innovations, including text messaging, smart phone applications, and electronic monitoring devices, aimed at improving asthma controller adherence are being rapidly introduced both into clinical care and directly marketed to patients. This review analyzes recent clinical trials implement...

journal_title：Current opinion in allergy and clinical immunology

authors： Anderson WC 3rd

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing understanding of mechanisms and influencing factors in the development of uncontrolled inflammatory responses in atopy and asthma should serve for the introduction of new preventive measures. This review tries to present the current state of the art and resumes that until now, no really eff...

journal_title：Current opinion in allergy and clinical immunology

authors： Lau S

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews recent findings on the skin microbiome. It provides an update on the current understanding of the role of microbiota in healthy skin and in inflammatory and allergic skin diseases. RECENT FINDINGS:Advances in computing and high-throughput sequencing technology have enabled in-dep...

journal_title：Current opinion in allergy and clinical immunology

authors： Zeeuwen PL,Kleerebezem M,Timmerman HM,Schalkwijk J

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Dental professionals and their physicians frequently do not recognize, accurately diagnose or appropriately manage occupational allergies. Dental allergen identification, diagnostics and practical avoidance strategies are summarized in this review. RECENT FINDINGS:Methacrylates, natural rubber latex ...

journal_title：Current opinion in allergy and clinical immunology

authors： Hamann CP,Rodgers PA,Sullivan KM

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes how plasma is sourced for fractionation into plasma-derived medicinal products (PDMPs), such as immunoglobulin (Ig) together with differences between plasma from whole blood (recovered plasma) and from plasmapheresis (source plasma) in terms of global plasma supply. Specific area...

journal_title：Current opinion in allergy and clinical immunology

authors： Prevot J,Jolles S

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:There is an unmet need for better immunological tests in cases of suspected occupational asthma to many workplace chemicals; here we consider the basophil activation test (BAT), a potential alternative to the detection of specific IgE antibodies. RECENT FINDINGS:BAT is fairly widely used in general a...

journal_title：Current opinion in allergy and clinical immunology

authors： Vera-Berrios RN,Feary J,Cullinan P

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Contact lens-induced papillary conjunctivitis (CLPC) is a common ocular allergic disease in contact lens wearers. In its more severe form, it can cause giant papillary conjunctivitis, resulting in contact lens intolerance and the need to discontinue the use of contact lenses. This review presents the ...

journal_title：Current opinion in allergy and clinical immunology

authors： Solomon A

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:An exposition of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to recommendations. RECENT FINDINGS:In this review, we outline the process whereby the strength of evidence from the literature undergoes a systematic reappraisal. The GRADE system allows four grad...

journal_title：Current opinion in allergy and clinical immunology

authors： Terracciano L,Brozek J,Compalati E,Schünemann H

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the current knowledge on remodeling in chronic sinus disease. RECENT FINDINGS:Chronic sinus disease is characterized by persistent inflammation of the nasal and paranasal mucosa and is currently classified into two major subgroups on the basis of the absence (CRSsNP) or presence (CRSwNP)...

journal_title：Current opinion in allergy and clinical immunology

authors： Van Bruaene N,Bachert C

更新日期：2011-02-01 00:00:00

abstract：:Conventional immunotherapy may be associated with the development of adverse reactions, including anaphylaxis, due to the use of increasing doses of allergen. Standardization of extracts is necessary in order to assess the correct amount of allergen administered. In recent years, increased knowledge on the molecular s...

journal_title：Current opinion in allergy and clinical immunology

authors： Pomés A,Chapman MD

更新日期：2001-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Gene therapy for severe combined immunodeficiency due to adenosine deaminase deficiency has moved from the early trials of safety and feasibility to recent studies demonstrating efficacy and clinical benefit. This review describes the latest advances in gene therapy trials for this condition using per...

journal_title：Current opinion in allergy and clinical immunology

authors： Aiuti A,Ficara F,Cattaneo F,Bordignon C,Roncarolo MG

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Dry eye disease (DED) is a complex, multifactorial condition that is challenging to diagnose and monitor clinically. To date, diagnosis has consisted largely of self-reported symptom questionnaires and a collection of clinical tests including vital dye staining, estimation of tear breakup time and Sch...

journal_title：Current opinion in allergy and clinical immunology

authors： Dohlman TH,Ciralsky JB,Lai EC

更新日期：2016-10-01 00:00:00