Abstract:
PURPOSE OF REVIEW:This review discusses the immunology of chronic beryllium disease. It addresses the importance of the interaction between class II molecules and the T cells that recognize beryllium, along with the subsequent immune response that results in sensitization and disease, and genetic factors leading to variation in this response. RECENT FINDINGS:HLA-DPB1 with a glutamic acid at amino acid position 69 (Glu69) confers increased risk of beryllium sensitization and is not specific for chronic beryllium disease. The degree of negative surface charge of the molecule may increase risk of chronic beryllium disease but not sensitization. In the absence of Glu69, HLA-DRB1 alleles may function in beryllium presentation, increasing the risk of chronic beryllium disease. The T-cell response as assessed by the beryllium lymphocyte proliferation test is dependent on central memory T-cells, while Th1 cytokine secretion leading to granulomatous inflammation and chronic beryllium disease is dependent on the activity of effector memory T cells. Polymorphisms in cytokine genes, such as the TGF-beta1 gene, also affect the risk of chronic beryllium disease and more severe disease. SUMMARY:The current diagnostic criteria for sensitization and chronic beryllium disease rely on the beryllium lymphocyte proliferation test. By understanding the novel immunologic mechanisms and genetic factors associated with sensitization and chronic beryllium disease, we may improve our ability to detect beryllium health effects with new diagnostics, and hopefully refine therapies for disease.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Samuel G,Maier LAdoi
10.1097/ACI.0b013e3282f824a4subject
Has Abstractpub_date
2008-04-01 00:00:00pages
126-34issue
2eissn
1528-4050issn
1473-6322pii
00130832-200804000-00006journal_volume
8pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Defining predisposition to allergic drug reactions has largely focussed on HLA associations, but other genetic and nongenetic factors are also likely to be involved. RECENT FINDINGS:Polymorphic genetic variants in cytokine genes, including IL-10, and co-signalling pathways, including CTLA4, have been...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000459
更新日期:2018-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Allergic diseases have only recently gained serious attention in Africa. This review discusses recent studies that have focused on allergy among Africans and people of African ancestry. RECENT FINDINGS:Time trend studies of the prevalence of allergies in Africa show a consistent increase over a perio...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32830ebb70
更新日期:2008-10-01 00:00:00
abstract:PURPOSE OF REVIEW:One strategy to improve asthma control is to identify risk factors for uncontrolled asthma in epidemiologic studies and then consider those risk factors as potential targets for intervention. This article reviews predictors of impairment based on validated tools and predictors of severe asthma exacerb...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32835335ac
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To understand the impact of globalization in the management of anaphylaxis and identify potential strategies to improve patients' care and prevention. RECENT FINDINGS:Developments in the field of anaphylaxis have been consistently following these globalization trends offering possibilities of collabo...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000467
更新日期:2018-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Vernal keratoconjunctivitis (VKC) is a rare chronic self-limiting allergic inflammatory disease of the ocular surface mostly affecting young boys in their first decade of life. In the last few years a new clinical entity of VKC has been described: adult VKC. Two variants have been identified according...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000672
更新日期:2020-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to provide a brief discussion on the differential diagnosis for peripheral eosinophilia. We will then focus on targeted immunotherapies for atopic disease, their effects on absolute peripheral eosinophil counts, and use of peripheral eosinophils as a predictor of treatmen...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,收录出版
doi:10.1097/ACI.0000000000000617
更新日期:2020-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this article is to evaluate developments in the knowledge of suppressor of cytokine signaling (SOCS) protein ocular allergy and the potential of SOCS proteins as targets for therapeutic strategies. RECENT FINDINGS:The family of proteins designated SOCS proteins plays an important role in ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000244797.48981.6d
更新日期:2006-10-01 00:00:00
abstract::Ants belong to the order Hymenoptera, along with bees, wasps, yellow jackets, etc., they are the most successful animal genera in this world. It is their selfless social structure which accounts for their huge impact. Their effect on man ranges from the parasol ant, which makes plant cultivation untenable in certain p...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000011036.74215.95
更新日期:2001-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Mast cells and eosinophils are the main effector cells in allergic inflammation, but there is now compelling evidence that fibroblasts are also important players in the inflammatory response. In fact, they respond to different stimuli and release several mediators that modulate mast-cell and eosinophi...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200310000-00012
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the results from recent studies that assessed the burden of allergic diseases on the patients' every-day life, or contributed to new advances in monitoring quality-of-life in allergic disorders. This review will not report the numerous clinical trials that included quality-of-life as an outc...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200306000-00005
更新日期:2003-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma/chronic obstructive pulmonary disease overlap (ACO) continues to be a poorly understood condition. This review discusses newly proposed criteria and potential biomarkers in ACO, to aid in diagnosis and research studies, and prudent therapeutic approaches. RECENT FINDINGS:A global expert panel ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000596
更新日期:2020-02-01 00:00:00
abstract:PURPOSE OF REVIEW:To present the most recent evidence on beta-lactam hypersensitivity reactions in children. RECENT FINDINGS:Drug provocation tests (DPTs) are the gold standard when investigating beta-lactam allergy in children and evidence is increasingly supporting DPTs without skin tests as a safe approach when eva...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000453
更新日期:2018-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Biological agents have been a treatment option for many chronic immune-mediated diseases as well as oncological conditions. The issue of infusion reactions is of particular importance and at least in some cases related to the immunogenicity of these drugs with the production of antidrug antibodies. In...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000315
更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Component-resolved diagnosis (CRD) is an advanced tool capable of aiding the clinician in fine tuning the diagnosis of the causal allergens of a reaction with the added value of providing information of severity risk, potential cross-reactivity, and subsequently, guiding management measures. This revi...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000261
更新日期:2016-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Complementary medicines, including acupuncture and Chinese herbal medicine, are being used increasingly for the management of allergies such as allergic rhinitis. Until relatively recently, however, evidence for the efficacy and safety of these therapies in allergic conditions has been lacking. RECEN...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000225156.29780.36
更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma and rhinitis are commonly associated and they influence their respective control. New observations have contributed to better understand how to assess those conditions and how they influence each other. RECENT FINDINGS:Recent studies found that not only the intensity, but also the duration of ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328357cc32
更新日期:2012-10-01 00:00:00
abstract::The complex relationship between allergen exposure, atopic sensitization and asthma in individuals and in populations has recently been a subject of controversy. A number of studies have demonstrated that allergen exposure in sensitized asthmatic individuals increases the severity of disease. A simple dose-response re...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000010997.12990.aa
更新日期:2001-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review will cover advances over the past year in defining airway endotypes in asthma by gene expression and the relationship between these endotypes and clinical traits. RECENT FINDINGS:Expression profiling studies of asthmatic airway samples continue to reveal significant heterogeneity in airwa...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000148
更新日期:2015-04-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review, we summarize the latest publications on the genetic and environmental determinants of allergic rhinitis. RECENT FINDINGS:Recent advances in genetic technology and bioinformatics have enabled simultaneous unbiased analysis of the entire genome regarding DNA sequence variants, epigeneti...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000207
更新日期:2015-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Evidence suggests that some structural changes caused by mucosal remodeling may be primarily irreversible, which theoretically challenges the current management model of chronic rhinosinusitis (CRS). The relationship between inflammation and remodeling in the mucosa remains complex, yet better underst...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32835ad09e
更新日期:2013-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent application of advanced culture-independent molecular techniques for the identification of microorganisms has contributed to our knowledge on the role of early-life microbial exposure and colonization in health and disease. The purpose of this review is to present the current perspectives regar...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000036
更新日期:2014-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight recent advances in gene-expression profiling of nasal polyps in patients with chronic rhinosinusitis and aspirin-sensitive asthma. RECENT FINDINGS:Gene-expression profiling has allowed simultaneous interrogation of thousands of genes, including the entire ge...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32831d8170
更新日期:2009-02-01 00:00:00
abstract:PURPOSE OF REVIEW:New biological agents, in addition to the well-established omalizumab, have been nowadays introduced into clinical practice for severe asthma. This suggested the possibility of an at-home self-administration, as currently happening for other biological agents for immune-mediated diseases. RECENT FIND...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000656
更新日期:2020-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS:The aggregated evidence indicates a consistent detrimental effect of...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000342
更新日期:2017-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Anaphylactic cardiovascular collapse can be resistant to treatment with epinephrine (adrenaline) and, in some cases, diagnostic uncertainty compromises follow-up care. The purpose of this review is to examine recent studies relevant to the management and diagnosis of this condition. RECENT FINDINGS:N...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000174158.78626.35
更新日期:2005-08-01 00:00:00
abstract::Ocular allergy presents unsolved mysteries in molecular and cellular mechanisms, and at the same time continues to challenge ophthalmologists daily in a wide array of disease forms. The recent understanding of the key role of the T helper type 2 cytokines, adhesion molecules and chemokines may provide future avenues f...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000011063.28808.cc
更新日期:2001-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Irreversible airflow limitation develops in some patients with asthma and is related to poorer prognosis. This paper reviews recent literature on natural course, risk factors, and potential mechanisms of persistent airflow limitation in asthma. RECENT FINDINGS:The natural course of persistent airflow...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3282f3b5b5
更新日期:2008-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The key features of aspirin-exacerbated respiratory diseases (AERDs) include chronic, severe asthma and a high prevalence (60-80%) of chronic rhinosinusitis with nasal polyps, all of which are exacerbated by exposure to aspirin and other NSAIDs. Although the pathogenic mechanisms of AERD are not compl...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000021
更新日期:2014-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Secondhand smoke (SHS) exposure in the workplace remains common and has important acute and chronic health effects. The present study reviews the recent evidence linking workplace SHS exposure with poor health and the benefits of smoke-free workplace legislation. RECENT FINDINGS:Workplace SHS exposur...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32833649b3
更新日期:2010-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Key aspects and outcomes from the recently published guidance on the regulation of allergen products are summarized. RECENT FINDINGS:A new regulatory guideline has been published to enhance harmonized national approaches on the regulation of allergen products and thereby strengthen the availability o...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000687
更新日期:2020-12-01 00:00:00