Abstract:
PURPOSE OF REVIEW:In this review, we summarize the latest publications on the genetic and environmental determinants of allergic rhinitis. RECENT FINDINGS:Recent advances in genetic technology and bioinformatics have enabled simultaneous unbiased analysis of the entire genome regarding DNA sequence variants, epigenetic modifications and gene expression, providing functional correlates for DNA variants and phenotypes. As a result, new genes of mitochondrial and B-lymphocyte metabolism have been associated with allergic rhinitis phenotypes. Epidemiological studies recently showed an increased risk to develop allergic rhinitis in all age groups with reduction in farm exposure and in children with few older siblings. Climate changes seem to have also influenced pollen exposure and pollen-induced allergic disease. Lastly, occupational rhinitis has been increasingly recognized as a large burden to society. SUMMARY:In summary, new high throughput genetics research technologies have pointed to new previously unsuspected pathways that may modulate the risk of developing allergic rhinitis such as mitochondrial metabolism. In addition, recent environmental factors found to influence the risk of developing allergic rhinitis include exposure to farm, pollution, occupational agents, and changes in climate.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Chiarella SE,Fernandez R,Avila PCdoi
10.1097/ACI.0000000000000207subject
Has Abstractpub_date
2015-10-01 00:00:00pages
440-5issue
5eissn
1528-4050issn
1473-6322pii
00130832-201510000-00008journal_volume
15pub_type
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