Abstract:
PURPOSE OF REVIEW:Mast cells and eosinophils are the main effector cells in allergic inflammation, but there is now compelling evidence that fibroblasts are also important players in the inflammatory response. In fact, they respond to different stimuli and release several mediators that modulate mast-cell and eosinophil functionality. In several allergic conditions such as vernal keratoconjunctivitis, asthma and atopic dermatitis the chronic presence of the inflammatory process has been associated with fibrosis and tissue remodeling, which in turn could cause irreversible alterations in the organ anatomy and functions. This review will discuss current advances in mast cell, eosinophil and fibroblast interactions in terms of their importance in the perpetuation of allergic inflammation and in contributing to the fibrosis and/or remodeling process in ocular allergy. As a main example of allergic ocular diseases associated with fibrosis, vernal keratoconjunctivitis is discussed in the light of recent findings. RECENT FINDINGS:Several studies have recently shown that fibroblasts can modulate the functions of mast cells and eosinophils through the membrane form of stem cell factor and granulocyte-macrophage colony-stimulating factor, respectively. On the other hand, fibroblasts can be affected by inflammatory mediators derived from mast cells and eosinophils, such as transforming growth factor beta and nerve growth factor and by the T helper type 2 cytokines, IL-4 and IL-13, and vernal keratoconjunctivitis-derived fibroblasts display altered functions. SUMMARY:Considerable useful information has been gained about the role of mast cells, eosinophils and fibroblasts in the perpetuation of allergic inflammation and tissue fibrosis and/or remodeling in general, and specifically in ocular allergy.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Solomon A,Puxeddu I,Levi-Schaffer Fdoi
10.1097/00130832-200310000-00012keywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
389-93issue
5eissn
1528-4050issn
1473-6322journal_volume
3pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Food allergy has emerged as a significant health problem. Peanut allergy is a major cause of food-induced fatal and near fatal anaphylactic reactions, and the incidence in children is increasing. Attempts to manage peanut allergy by strict avoidance are often unsuccessful. The purpose of this review i...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000168796.20324.bd
更新日期:2005-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of the present review is to describe recent approaches aimed at improving the treatment of allergic diseases through allergen-specific immunotherapy (SIT). Special emphasis will be given to the approach based on specific targeting of the major histocompatibility complex (MHC) class-II anti...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283310fdf
更新日期:2009-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283445921
更新日期:2011-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000254
更新日期:2016-04-01 00:00:00
abstract::It is clear that airway smooth muscle plays an important role in the hyperresponsiveness and remodelling that occur in the asthmatic airway. This is by virtue of its roles as a contractile cell, a cell that undergoes proliferation as part of the inflammatory response, a cell that actively participates in the inflammat...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200202000-00008
更新日期:2002-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Secondhand smoke (SHS) exposure in the workplace remains common and has important acute and chronic health effects. The present study reviews the recent evidence linking workplace SHS exposure with poor health and the benefits of smoke-free workplace legislation. RECENT FINDINGS:Workplace SHS exposur...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32833649b3
更新日期:2010-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Although today's cornerstone therapies for asthma (inhaled bronchodilators and corticosteroids) target airway narrowing and lung inflammation, about half of treated asthmatic patients do not achieve good disease control. There is a clear need for new therapeutic approaches and novel drug targets. Rece...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000137
更新日期:2015-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Biological hypersensitivity to environmental stimuli is a fundamental feature of atopy predisposing to a number of clinically expressed disorders including allergic rhinitis, atopic dermatitis or eczema, and allergic asthma. There is provocative evidence that psychological stress constitutes an increa...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200502000-00006
更新日期:2005-02-01 00:00:00
abstract:PURPOSE OF REVIEW:To familiarize the reader with the recent developments in the identification of food protein allergens by proteomics mass spectrometry-based methods, named allergenomics. RECENT FINDINGS:The proteomic analysis of food protein allergens has became a hot topic in the food safety field in recent years. ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000160
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Component-resolved diagnosis (CRD) is an advanced tool capable of aiding the clinician in fine tuning the diagnosis of the causal allergens of a reaction with the added value of providing information of severity risk, potential cross-reactivity, and subsequently, guiding management measures. This revi...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000261
更新日期:2016-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening severe adverse drug reactions. Once thought to be idiosyncratic and unpredictable, there has been significant progress made in the understanding of the pathomechanism and pharmacogenetics of such reactions. These ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283630cc2
更新日期:2013-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma affects more than 25 million people worldwide and continues to grow in prevalence. According to a center for disease control and prevention (CDC) report, the total annual cost of asthma in the United States between 2008 and 2013, including medical care, absenteeism, and mortality, was $81.9 bil...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000518
更新日期:2019-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes current knowledge regarding the control of human mast cell and basophil signaling and recent developments using a new therapeutic platform consisting of a human bifunctional gamma and epsilon heavy chain (Fc gamma-Fc epsilon) protein to inhibit allergic reactivity. RECENT FINDI...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200412000-00015
更新日期:2004-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update on the syndrome X-linked hypogammaglobulinemia with isolated growth hormone deficiency, focusing on the pedigree described originally. RECENT FINDINGS:An additional case of X-linked hypogammaglobulinemia with isolated growth hormone deficiency and an unaffected male have been bor...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000191235.35879.29
更新日期:2005-12-01 00:00:00
abstract:PURPOSE:The aim of this review is to highlight the prevalence of allergic rhinitis in athletes and the impact this condition may have on their athletic performance. Furthermore, the optimal management of medical conditions in the elite athlete forms an important part of protecting the health of the athlete. RECENT FIN...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283445852
更新日期:2011-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Anaphylactic cardiovascular collapse can be resistant to treatment with epinephrine (adrenaline) and, in some cases, diagnostic uncertainty compromises follow-up care. The purpose of this review is to examine recent studies relevant to the management and diagnosis of this condition. RECENT FINDINGS:N...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000174158.78626.35
更新日期:2005-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The current EAACI/GA²LEN/EDF/WAO treatment guidelines for the management of urticaria recommend omalizumab as fourth-line therapy. Within the last year, many reports of omalizumab treatment in chronic urticaria have been published. RECENT FINDINGS:Two multicenter, randomized, placebo-controlled trial...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328355365a
更新日期:2012-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Children with asthma require care that is seamlessly coordinated so that asthma symptoms are recognized and managed at home and at school. The purpose of this review is to discuss recent consensus recommendations in school-based asthma care. RECENT FINDINGS:The School-based Asthma Management Program ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000347
更新日期:2017-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes how plasma is sourced for fractionation into plasma-derived medicinal products (PDMPs), such as immunoglobulin (Ig) together with differences between plasma from whole blood (recovered plasma) and from plasmapheresis (source plasma) in terms of global plasma supply. Specific area...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000696
更新日期:2020-12-01 00:00:00
abstract::The role of indoor allergen exposure in the development of sensitization and asthma remains a subject of controversy. From a number of cross-sectional and longitudinal studies we can conclude that there is a very close association between allergen exposure and the sensitization of an individual. The dose-response rela...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000011053.76412.14
更新日期:2001-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to describe the impact of asthma treatment non-adherence on patients and the healthcare system, and to outline areas of responsibility towards improved adherence. RECENT FINDINGS:The average cost of healthcare expenses for each person in the United States in 2002 was 544...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200406000-00009
更新日期:2004-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an overview on the role of gut mucosal immunity in the development of tolerance against allergy to food. RECENT FINDINGS:The gastrointestinal tract, through innate and specific immunologic factors, acts as a defense against ingested antigens. In addition to the mucous membrane integrity an...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32833982ab
更新日期:2010-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the results from recent studies that assessed the burden of allergic diseases on the patients' every-day life, or contributed to new advances in monitoring quality-of-life in allergic disorders. This review will not report the numerous clinical trials that included quality-of-life as an outc...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200306000-00005
更新日期:2003-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To understand the impact of globalization in the management of anaphylaxis and identify potential strategies to improve patients' care and prevention. RECENT FINDINGS:Developments in the field of anaphylaxis have been consistently following these globalization trends offering possibilities of collabo...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000467
更新日期:2018-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to describe the role of precision medicine in the diagnosis, treatment, and monitoring of cow's milk allergy. RECENT FINDINGS:The development of 'omics' sciences in the field of food allergy has led to a better understanding of the allergenicity of cow's milk proteins and si...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000640
更新日期:2020-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This article provides an overview of novel nanoscale structures potentially applicable to the field of allergy, and to discuss the required properties, advantages, and disadvantages of those nanostructures for clinical application focusing on diagnosis of drug hypersensitivity reactions. RECENT FINDI...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000282
更新日期:2016-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Although cough is one of the defining symptoms of asthma, wheeze, chest tightness and breathlessness have generally received more attention. The impact of coughing for patients may be more important than currently appreciated and has been rated more troublesome than wheeze, chest tightness or disturba...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328334e75f
更新日期:2010-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Increasing understanding of mechanisms and influencing factors in the development of uncontrolled inflammatory responses in atopy and asthma should serve for the introduction of new preventive measures. This review tries to present the current state of the art and resumes that until now, no really eff...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32835eb7b1
更新日期:2013-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Umbilical cord haematopoietic stem cell transplantation for primary immunodeficiencies is examined with other developments in treatment. Cord blood biology is reviewed, and advantages and disadvantages of umbilical cord blood stem cell transplantation for primary immunodeficiencies discussed. Clinical...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3282f1d6b6
更新日期:2007-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Technological innovations, including text messaging, smart phone applications, and electronic monitoring devices, aimed at improving asthma controller adherence are being rapidly introduced both into clinical care and directly marketed to patients. This review analyzes recent clinical trials implement...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000343
更新日期:2017-04-01 00:00:00