Secondhand smoke at work.

abstract：PURPOSE OF REVIEW:Unverified penicillin allergy is being increasingly recognized as a public health concern. The ideal protocol for verifying true clinically significant IgE-mediated penicillin allergy needs to use only commercially available materials, be well tolerated and easy to perform in both the inpatient and ou...

journal_title：Current opinion in allergy and clinical immunology

authors： Macy E

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Asthma affects more than 25 million people worldwide and continues to grow in prevalence. According to a center for disease control and prevention (CDC) report, the total annual cost of asthma in the United States between 2008 and 2013, including medical care, absenteeism, and mortality, was $81.9 bil...

journal_title：Current opinion in allergy and clinical immunology

authors： Nalin U,Stout S,Portnoy JM

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence for adverse respiratory effects of occupational exposure to disinfectants and cleaning products (DCPs) has grown in the last two decades. The relationship between DCPs and asthma is well documented but questions remain regarding specific causal agents. Beyond asthma, associations between DCPs...

journal_title：Current opinion in allergy and clinical immunology

authors： Dumas O

更新日期：2020-12-05 00:00:00

abstract：PURPOSE OF REVIEW:Defining predisposition to allergic drug reactions has largely focussed on HLA associations, but other genetic and nongenetic factors are also likely to be involved. RECENT FINDINGS:Polymorphic genetic variants in cytokine genes, including IL-10, and co-signalling pathways, including CTLA4, have been...

journal_title：Current opinion in allergy and clinical immunology

authors： Gibson A,Ogese M,Pirmohamed M

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to recap recent published data on immunological mechanisms underlying sublingual immunotherapy (SLIT). RECENT FINDINGS:Although several alternative noninvasive allergen application strategies have been investigated in allergen-specific immunotherapy, local intraoral allergen applicat...

journal_title：Current opinion in allergy and clinical immunology

authors： Allam JP,Novak N

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Personalized medicine encompasses the use of biological information such as genomics to provide tailored interventions for patients. The review explores the ethical, legal, and social issues that have emerged with personalized medicine and must be considered because of the complex nature of providing ...

journal_title：Current opinion in allergy and clinical immunology

authors： Joly Y,Saulnier KM,Osien G,Knoppers BM

更新日期：2014-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence suggests that some structural changes caused by mucosal remodeling may be primarily irreversible, which theoretically challenges the current management model of chronic rhinosinusitis (CRS). The relationship between inflammation and remodeling in the mucosa remains complex, yet better underst...

journal_title：Current opinion in allergy and clinical immunology

authors： Bassiouni A,Chen PG,Wormald PJ

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:As drug allergy research aims to inform clinical practice, implementation of best practices may be influenced by financial resources required to incorporate new interventions and the resulting clinical and economic returns on those resource investments. The present review summarizes new insights into ...

journal_title：Current opinion in allergy and clinical immunology

authors： Mattingly TJ 2nd

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we herein describe the progress in management of severe asthma, evolving from a 'blockbuster approach' to a more personalized approach targeted to the utilization of endotype-driven therapies. RECENT FINDINGS:Severe asthma characterization in phenotypes and endotypes, by means of spec...

journal_title：Current opinion in allergy and clinical immunology

authors： Canonica GW,Ferrando M,Baiardini I,Puggioni F,Racca F,Passalacqua G,Heffler E

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the theoretical background and current evidence regarding parent-initiated oral corticosteroid (PIOCS) therapy in preschool wheeze and asthma in school-aged children. RECENT FINDINGS:In school-aged children with asthma PIOCS, given during acute episodes, has been associated with a modest re...

journal_title：Current opinion in allergy and clinical immunology

authors： Vuillermin PJ,Robertson CF,South M

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Allergen immunotherapy (AIT) is still the only causal treatment for allergic rhinitis and asthma. However, conventional subcutaneous AIT administration schedules are time-consuming and safety issues still play a role; for sublingual AIT, the best efficacy is still investigated and for food allergy the...

journal_title：Current opinion in allergy and clinical immunology

authors： Larenas-Linnemann D

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In 2000, inhalation of butter flavoring vapors was first associated with clinical bronchiolitis obliterans among workers in microwave popcorn production. Toxicologic and epidemiologic studies in the succeeding 5 years have intervention and research implications. RECENT FINDINGS:Irreversible obstructi...

journal_title：Current opinion in allergy and clinical immunology

authors： Kreiss K

更新日期：2007-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Atopic dermatitis is typified by itchy, inflamed skin. It is increasingly common in the developed world and is a major cause of morbidity in infants and young children. Most children with the disease have high levels of immunoglobulin E and many have concomitant asthma. The cause of the disease is unk...

journal_title：Current opinion in allergy and clinical immunology

authors： Cookson WO,Moffatt MF

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Asthma and rhinitis are commonly associated and they influence their respective control. New observations have contributed to better understand how to assess those conditions and how they influence each other. RECENT FINDINGS:Recent studies found that not only the intensity, but also the duration of ...

journal_title：Current opinion in allergy and clinical immunology

authors： Boulay ME,Morin A,Laprise C,Boulet LP

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Allergic conjunctivitis is common and may be the most prominent or the only feature of allergies. Immunotherapy has been used as a primary treatment for allergies since the early 1900s. Currently the use of immunotherapy for allergic rhinoconjunctivitis is well established and has been shown to decrea...

journal_title：Current opinion in allergy and clinical immunology

authors： Bielory L,Mongia A

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Although today's cornerstone therapies for asthma (inhaled bronchodilators and corticosteroids) target airway narrowing and lung inflammation, about half of treated asthmatic patients do not achieve good disease control. There is a clear need for new therapeutic approaches and novel drug targets. Rece...

journal_title：Current opinion in allergy and clinical immunology

authors： Grassin-Delyle S,Naline E,Devillier P

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To recognize the relevance of serum tryptase measurement as a useful tool for the diagnosis of allergic diseases and mast cell disorders. RECENT FINDINGS:Recent data on the role of mast cells and tryptase in allergic and other diseases provide new understanding into the mechanisms and causes of anaph...

journal_title：Current opinion in allergy and clinical immunology

authors： Bonadonna P,Scaffidi L,Boni E

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Irreversible airflow limitation develops in some patients with asthma and is related to poorer prognosis. This paper reviews recent literature on natural course, risk factors, and potential mechanisms of persistent airflow limitation in asthma. RECENT FINDINGS:The natural course of persistent airflow...

journal_title：Current opinion in allergy and clinical immunology

authors： ten Brinke A

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes how plasma is sourced for fractionation into plasma-derived medicinal products (PDMPs), such as immunoglobulin (Ig) together with differences between plasma from whole blood (recovered plasma) and from plasmapheresis (source plasma) in terms of global plasma supply. Specific area...

journal_title：Current opinion in allergy and clinical immunology

authors： Prevot J,Jolles S

更新日期：2020-12-01 00:00:00

abstract：PURPOSE OF REVIEW:During the past decade, easy access to sequence analyses has allowed us to increase our understanding of the pathogenesis of severe combined immunodeficiencies. Here, we describe the expanding clinical and immunological spectrum associated with Omenn syndrome phenotype. In particular, we review the ce...

journal_title：Current opinion in allergy and clinical immunology

authors： Marrella V,Maina V,Villa A

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the present review is to describe recent approaches aimed at improving the treatment of allergic diseases through allergen-specific immunotherapy (SIT). Special emphasis will be given to the approach based on specific targeting of the major histocompatibility complex (MHC) class-II anti...

journal_title：Current opinion in allergy and clinical immunology

authors： Crameri R,Kündig TM,Akdis CA

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to describe the impact of asthma treatment non-adherence on patients and the healthcare system, and to outline areas of responsibility towards improved adherence. RECENT FINDINGS:The average cost of healthcare expenses for each person in the United States in 2002 was 544...

journal_title：Current opinion in allergy and clinical immunology

authors： Bender BG,Rand C

更新日期：2004-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this paper is to review and discuss recent studies on component-resolved diagnostics in food allergy, involving panels of pure allergen molecules or arrays of peptides derived from allergen sequences, and to summarize the reporting of new food allergens during the past 2 years. RECENT ...

journal_title：Current opinion in allergy and clinical immunology

authors： Lidholm J,Ballmer-Weber BK,Mari A,Vieths S

更新日期：2006-06-01 00:00:00

abstract：:It is clear that airway smooth muscle plays an important role in the hyperresponsiveness and remodelling that occur in the asthmatic airway. This is by virtue of its roles as a contractile cell, a cell that undergoes proliferation as part of the inflammatory response, a cell that actively participates in the inflammat...

journal_title：Current opinion in allergy and clinical immunology

authors： Black JL,Johnson PR

更新日期：2002-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The prevalence of allergic disorders has more than doubled in the last two decades leading to increased community concern and anxiety, and unprecedented demand for allergy-specialist services. However, although allergic reactions are common, anaphylaxis is uncommon and fatal anaphylaxis is rare. This ...

journal_title：Current opinion in allergy and clinical immunology

authors： Tang ML,Osborne N,Allen K

更新日期：2009-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Exhaled nitric oxide has been proposed as a useful noninvasive marker of airway inflammation in asthma. Great efforts have been made to standardize the methodology for exhaled nitric oxide measurement in both children and adults. As a consequence there is now an opportunity to establish the precise re...

journal_title：Current opinion in allergy and clinical immunology

authors： Payne DN

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Most asthma patients are easily managed with a standard combination of therapies consisting of inhaled controller and reliever drugs, but there remains a large unmet need at the severe end of the disease spectrum. For these patients, development of safer and more effective therapies for asthmatic pati...

journal_title：Current opinion in allergy and clinical immunology

authors： Caruso M,Crisafulli E,Lizzio R,Polosa R

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF THE REVIEW:Recent studies on the pathogenesis of allergy in both man and experimental animals continue to show the importance of commensal bacteria in the gastrointestinal tract in stimulating and directing the immune system. The interest in modulating commensal bacterial flora with prebiotics and probiotics...

journal_title：Current opinion in allergy and clinical immunology

authors： Savilahti E,Kuitunen M,Vaarala O

更新日期：2008-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to examine in detail the new advances in the pathomechanisms and diagnosis of immediate and nonimmediate hypersensitivity reactions to quinolones, as well as analyze cross-reactivity among different quinolones. RECENT FINDINGS:Hypersensitivity reactions to quinolones, es...

journal_title：Current opinion in allergy and clinical immunology

authors： Blanca-López N,Andreu I,Torres Jaén MJ

更新日期：2011-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitates a better understanding, accurate diagnosis, and proper management of asthmatic reactions provoked at the workplace. RECENT FINDINGS:Increased recruitment and infiltration of ne...

journal_title：Current opinion in allergy and clinical immunology

authors： Choi Y,Lee Y,Park HS

更新日期：2019-04-01 00:00:00