Abstract:
PURPOSE OF REVIEW:Atopic dermatitis is typified by itchy, inflamed skin. It is increasingly common in the developed world and is a major cause of morbidity in infants and young children. Most children with the disease have high levels of immunoglobulin E and many have concomitant asthma. The cause of the disease is unknown, but it is highly heritable. Identification of the genes and genetic variants underlying atopic dermatitis may lead to new treatments and better classification of children with the disease. RECENT FINDINGS:Preliminary genetic studies have identified genes or clusters of genes that are expressed in the outermost layer of the skin to be just as important as genes that may modify the atopic process. These genes may influence other diseases, including psoriasis. Genome screens in mouse models seem to indicate involvement of some of the equivalent chromosomal regions as for human disease. SUMMARY:The findings suggest that atopy in atopic dermatitis may be a secondary process, rather than the cause of the disease. The barrier function of the skin is seen not to be merely passive. Identification of the genes underlying atopic dermatitis is feasible and likely within a few years.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Cookson WO,Moffatt MFdoi
10.1097/00130832-200210000-00003keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
383-7issue
5eissn
1528-4050issn
1473-6322journal_volume
2pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The current EAACI/GA²LEN/EDF/WAO treatment guidelines for the management of urticaria recommend omalizumab as fourth-line therapy. Within the last year, many reports of omalizumab treatment in chronic urticaria have been published. RECENT FINDINGS:Two multicenter, randomized, placebo-controlled trial...
journal_title:Current opinion in allergy and clinical immunology
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更新日期:2012-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2002-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,收录出版
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2018-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2019-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2009-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2010-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2002-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To understand the impact of globalization in the management of anaphylaxis and identify potential strategies to improve patients' care and prevention. RECENT FINDINGS:Developments in the field of anaphylaxis have been consistently following these globalization trends offering possibilities of collabo...
journal_title:Current opinion in allergy and clinical immunology
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更新日期:2018-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Food allergy has emerged as a significant health problem. Peanut allergy is a major cause of food-induced fatal and near fatal anaphylactic reactions, and the incidence in children is increasing. Attempts to manage peanut allergy by strict avoidance are often unsuccessful. The purpose of this review i...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000168796.20324.bd
更新日期:2005-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32834c311a
更新日期:2011-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Many interventions have been undertaken in managing asthma in a population-based framework. The identification of successful interventions would guide policy implementation to improve outcomes in patient morbidity and mortality and healthcare costs. RECENT FINDINGS:Several studies have focussed on em...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32814a5583
更新日期:2007-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Baker's allergy and asthma continue to represent an important contributor of occupational asthma globally. This review identified recent studies related to the prevention of baker's allergy and asthma. RECENT FINDINGS:Studies with respect to regulatory exposure standards, workplace control measures a...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000612
更新日期:2020-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an overview of the pathogenic mechanisms underlying the correlation between ocular allergy and dry eye disease (DED), highlighting how the first condition may be a risk factor for the second one. RECENT FINDINGS:Recent advances in our comprehension of the pathogenesis of ocular allergy and...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000471
更新日期:2018-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Current understanding of the role of oxidative stress in airway inflammation suggests that antioxidant therapy may be important to optimize the treatment. This review summarizes recent investigations of novel antioxidant agents for upper airway inflammation, with selected studies focused on lower airw...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328334f613
更新日期:2010-02-01 00:00:00
abstract:PURPOSE OF REVIEW:In adults with eosinophilic esophagitis (EoE), a chronic, inflammatory immune-mediated condition of the esophagus, both inflammation and fibrosis are likely associated with symptom generation. Therefore, assessing symptom-based patient-reported outcomes (PROs), defined by US Food and Drug Administrati...
journal_title:Current opinion in allergy and clinical immunology
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更新日期:2019-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2016-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2014-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2006-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2007-08-01 00:00:00
abstract::This review summarizes recent advances and findings in the area of 'hidden' food allergens, i.e. allergenic foods that can either contaminate other foods, or be 'disguised' as part of a food, and cause allergic reactions. Newly emerging allergenic foods of increasing importance, recently developed methods for the dete...
journal_title:Current opinion in allergy and clinical immunology
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更新日期:2001-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The main feature of allergen-specific immunotherapy is its capacity to modify the natural history of the disease, reducing the development of asthma and new sensitizations after 3-4 years of treatment. For this reason, adherence to the therapy is mandatory, as happens for all chronic medical treatment...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2009-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2004-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Cow's milk allergy affects 2-3% of young children, the economic impact of which necessitates search for simple diagnostic tools and affordable milk substitutes. This review examines recent studies on the diagnosis of cow's milk allergy as well as on the allergenicity of milk from other mammalian speci...
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更新日期:2009-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This article provides an overview of novel nanoscale structures potentially applicable to the field of allergy, and to discuss the required properties, advantages, and disadvantages of those nanostructures for clinical application focusing on diagnosis of drug hypersensitivity reactions. RECENT FINDI...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2016-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Anaphylaxis due to ant sting is increasingly being recognized as a significant problem. Severe allergic reactions to ants are well described in the south-eastern United States, but have only been recognized in recent years as being important in other parts of the world. There are many different ant sp...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00