Abstract:
PURPOSE OF REVIEW:Asthma affects more than 25 million people worldwide and continues to grow in prevalence. According to a center for disease control and prevention (CDC) report, the total annual cost of asthma in the United States between 2008 and 2013, including medical care, absenteeism, and mortality, was $81.9 billion. Although the National Institute of Health guidelines recommend fixed inhaled corticosteroid (ICS) dosing, the 2008-2010 Medical Expenditure Panel Survey showed that asthma is still poorly controlled. Single inhaler maintenance and reliever therapy (SMART) offers a possible alternative management plan. This is a review of SMART vs. current treatment guidelines. RECENT FINDINGS:SMART addresses variable inflammation with symptom-driven dosing of ICS. It relies on a combination inhaler that has a long-acting β-agonist, which has an immediate onset of action to provide quick relief, in combination with an ICS. Recent studies show that SMART decreases the frequency and severity of asthma exacerbations when compared to fixed ICS dosing. In addition, intermittent use of ICS gave a reduced effect on growth and permitted a lower total amount of ICS to be delivered. SUMMARY:SMART appears to outperform treatment that is based on current guidelines in the United States. As inhalers capable of being used for SMART are already approved, what is needed is Food and Drug Administration approval of the SMART strategy.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Nalin U,Stout S,Portnoy JMdoi
10.1097/ACI.0000000000000518subject
Has Abstractpub_date
2019-04-01 00:00:00pages
111-117issue
2eissn
1528-4050issn
1473-6322journal_volume
19pub_type
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3282f3f42f
更新日期:2008-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32835ad09e
更新日期:2013-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32833aa54d
更新日期:2010-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2005-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2021-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000246617.41871.40
更新日期:2006-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The key features of aspirin-exacerbated respiratory diseases (AERDs) include chronic, severe asthma and a high prevalence (60-80%) of chronic rhinosinusitis with nasal polyps, all of which are exacerbated by exposure to aspirin and other NSAIDs. Although the pathogenic mechanisms of AERD are not compl...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000021
更新日期:2014-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000307
更新日期:2016-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the role of metropolitan endotoxin exposure in asthma and allergy, emphasizing recently published articles (i.e. April 2002-June 2003). RECENT FINDINGS:In infants and toddlers in metropolitan communities, higher endotoxin levels in house dust are associated with less atopy and increased whe...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200310000-00002
更新日期:2003-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000191235.35879.29
更新日期:2005-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to describe the role of precision medicine in the diagnosis, treatment, and monitoring of cow's milk allergy. RECENT FINDINGS:The development of 'omics' sciences in the field of food allergy has led to a better understanding of the allergenicity of cow's milk proteins and si...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000640
更新日期:2020-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200412000-00015
更新日期:2004-12-01 00:00:00
abstract::The role of indoor allergen exposure in the development of sensitization and asthma remains a subject of controversy. From a number of cross-sectional and longitudinal studies we can conclude that there is a very close association between allergen exposure and the sensitization of an individual. The dose-response rela...
journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200412000-00005
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3280118a32
更新日期:2007-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2019-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200310000-00012
更新日期:2003-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2018-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32825ea543
更新日期:2007-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283445921
更新日期:2011-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000168796.20324.bd
更新日期:2005-06-01 00:00:00