Abstract:
PURPOSE OF REVIEW:The purpose of the present review is to introduce recent findings on the pathomechanisms of toxic epidermal necrolysis (TEN), which is characterized by widespread epidermal detachment due to keratinocyte apoptosis. RECENT FINDINGS:In the mechanism of epidermal damage, the roles of drug metabolites, cytotoxic lymphocytes, and apoptosis-inducing factors have been noted. In addition, recent studies have focused on monocytes/macrophages, which may participate in epidermal damage through the production of apoptosis-inducing factors and the expression of costimulatory factors with the ability to activate CD8 T cells. SUMMARY:Epidermal keratinocyte death is a hallmark of TEN. In a very high proportion of cases, drugs are responsible for TEN. It has been suggested that toxic drug metabolites produced by keratinocytes act like electrophilic agents to induce apoptosis and inflammation. Next, cytotoxic lymphocytes and monocytes function in the development of widespread epidermal damage through direct or indirect cytotoxic pathways. In addition, T-cell activation may be strengthened by the impairment of regulatory T-cell function and activated monocytes. The development of epidermal damage in TEN may require the coordinated action of these factors.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Tohyama M,Hashimoto Kdoi
10.1097/ACI.0b013e328355b865subject
Has Abstractpub_date
2012-08-01 00:00:00pages
376-82issue
4eissn
1528-4050issn
1473-6322journal_volume
12pub_type
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2015-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32825ea543
更新日期:2007-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2010-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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