Abstract:
PURPOSE OF REVIEW:To describe recent insight into the efficacy of intranasal corticosteroids in treating ocular signs and symptoms of allergic rhinoconjunctivitis. RECENT FINDINGS:The efficacy of intranasal corticosteroids in treating allergic nasal symptoms is well established, and recent evidence indicates that this class of medication may be effective at alleviating ocular symptoms as well. The present review reveals that the method of scoring ocular symptoms in a clinical trial may influence whether statistically significant improvements are detected among patients using intranasal corticosteroids. Improvement is more likely to be detected if symptoms are scored individually rather than pooled into a single ocular symptom score. Furthermore, the practice of allowing rescue medications likewise may preclude the ability to detect statistically significant differences in allergic eye symptoms between intranasal corticosteroids and controls. SUMMARY:Recent data show a promising effect of intranasal corticosteroids on ocular symptoms of allergic rhinoconjunctivitis. Additional trials should be conducted that require individuals to score ocular symptoms individually and forbid the use of rescue medications.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Origlieri C,Bielory Ldoi
10.1097/ACI.0b013e32830d8501subject
Has Abstractpub_date
2008-10-01 00:00:00pages
450-6issue
5eissn
1528-4050issn
1473-6322pii
00130832-200810000-00016journal_volume
8pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:In the US anterior ocular inflammatory disease (AOID) composed of the spectrum of ocular allergies, different forms of infectious conjunctivitis, and dry eye diseases, affects over 40% of the population. This review evaluates the current economic costs for AOID associated pharmacotherapies. RECENT FI...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000562
更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Evidence for adverse respiratory effects of occupational exposure to disinfectants and cleaning products (DCPs) has grown in the last two decades. The relationship between DCPs and asthma is well documented but questions remain regarding specific causal agents. Beyond asthma, associations between DCPs...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000710
更新日期:2020-12-05 00:00:00
abstract:PURPOSE OF REVIEW:Ocular allergy is often encountered by allergists, ophthalmologists, pediatricians, and primary care physicians. An understanding of the immunologic mechanisms, the differential diagnosis, the clinical features, and the treatment of ocular allergy will be useful to all physicians who encounter these p...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32834a9652
更新日期:2011-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Biological hypersensitivity to environmental stimuli is a fundamental feature of atopy predisposing to a number of clinically expressed disorders including allergic rhinitis, atopic dermatitis or eczema, and allergic asthma. There is provocative evidence that psychological stress constitutes an increa...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200502000-00006
更新日期:2005-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to provide a brief discussion on the differential diagnosis for peripheral eosinophilia. We will then focus on targeted immunotherapies for atopic disease, their effects on absolute peripheral eosinophil counts, and use of peripheral eosinophils as a predictor of treatmen...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,收录出版
doi:10.1097/ACI.0000000000000617
更新日期:2020-04-01 00:00:00
abstract:PURPOSE OF REVIEW:We provide an overview on the latest developments in primary immunodeficiency registries worldwide, on the basis of the recent literature amended by some older references to achieve completeness. RECENT FINDINGS:New primary immunodeficiency registries are emerging worldwide, although existing databas...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000113
更新日期:2014-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To analyse the most recently published studies on the prevalence of allergic conjunctivitis alone or in association with allergic rhinitis, and the clinical and demographic aspects of the disease. RECENT FINDINGS:Allergic conjunctivitis or conjunctival symptoms are present in 30-71% of patients with ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000204
更新日期:2015-10-01 00:00:00
abstract::The role of indoor allergen exposure in the development of sensitization and asthma remains a subject of controversy. From a number of cross-sectional and longitudinal studies we can conclude that there is a very close association between allergen exposure and the sensitization of an individual. The dose-response rela...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000011053.76412.14
更新日期:2001-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize the recent evidence on the effect of cleaning jobs on asthma, based on case reports and series of occupational asthma among cleaners, and epidemiological studies on the relationship between different characteristics of cleaning and asthma risk, as well as to ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000216849.64828.55
更新日期:2006-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses the immunology of chronic beryllium disease. It addresses the importance of the interaction between class II molecules and the T cells that recognize beryllium, along with the subsequent immune response that results in sensitization and disease, and genetic factors leading to var...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3282f824a4
更新日期:2008-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an overview of the pathogenic mechanisms underlying the correlation between ocular allergy and dry eye disease (DED), highlighting how the first condition may be a risk factor for the second one. RECENT FINDINGS:Recent advances in our comprehension of the pathogenesis of ocular allergy and...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000471
更新日期:2018-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma is the most common, potentially serious medical problem to complicate pregnancy. Women with asthma have been shown to be at increased risk of complications during pregnancy. Managing asthma during pregnancy is unique because the effect of both the illness and the treatment on the developing fet...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000168786.59335.c3
更新日期:2005-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Omalizumab has been proposed for controlling adverse reactions during drug desensitization. Our aim is to know the current evidence involving the use of omalizumab in drug-allergy desensitization. RECENT FINDINGS:Drug-allergy desensitization is not risk free, but it is a useful procedure and has been...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000648
更新日期:2020-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an update on the syndrome X-linked hypogammaglobulinemia with isolated growth hormone deficiency, focusing on the pedigree described originally. RECENT FINDINGS:An additional case of X-linked hypogammaglobulinemia with isolated growth hormone deficiency and an unaffected male have been bor...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000191235.35879.29
更新日期:2005-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The increase in asthma prevalence over the past 50 years suggests that exposures to environmental risk factors have also increased during this time. Environmental tobacco smoke is one of the most common indoor air pollutants and has been associated in epidemiologic studies with airway and allergic phe...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200410000-00002
更新日期:2004-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the results from recent studies that assessed the burden of allergic diseases on the patients' every-day life, or contributed to new advances in monitoring quality-of-life in allergic disorders. This review will not report the numerous clinical trials that included quality-of-life as an outc...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200306000-00005
更新日期:2003-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to compare and contrast the newer inhaled corticosteroid (ICS) ciclesonide with older ICSs in terms of pharmacodynamic and pharmacokinetic properties and how these affect comparative efficacy. In addition, clinical dosing strategies for ICSs including as-needed use will b...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328348a813
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Anaphylaxis due to ant sting is increasingly being recognized as a significant problem. Severe allergic reactions to ants are well described in the south-eastern United States, but have only been recognized in recent years as being important in other parts of the world. There are many different ant sp...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000136761.51195.01
更新日期:2004-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Umbilical cord haematopoietic stem cell transplantation for primary immunodeficiencies is examined with other developments in treatment. Cord blood biology is reviewed, and advantages and disadvantages of umbilical cord blood stem cell transplantation for primary immunodeficiencies discussed. Clinical...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3282f1d6b6
更新日期:2007-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma features a high degree of heterogeneity in both pathophysiology and therapeutic response, resulting in many asthma patients being treated inadequately. Biomarkers indicative of underlying pathological processes could be used to identify disease subtypes, determine prognosis and to predict or mo...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000426
更新日期:2018-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To recognize the relevance of serum tryptase measurement as a useful tool for the diagnosis of allergic diseases and mast cell disorders. RECENT FINDINGS:Recent data on the role of mast cells and tryptase in allergic and other diseases provide new understanding into the mechanisms and causes of anaph...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000569
更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This review describes how plasma is sourced for fractionation into plasma-derived medicinal products (PDMPs), such as immunoglobulin (Ig) together with differences between plasma from whole blood (recovered plasma) and from plasmapheresis (source plasma) in terms of global plasma supply. Specific area...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000696
更新日期:2020-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Children living in US inner cities experience disparate burdens of asthma, especially in severity, impairment, exacerbations, and morbidity. Investigations seeking to better understand the factors and mechanisms underlying asthma prevalence, severity, and exacerbation in children living in these commu...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000423
更新日期:2018-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS:The aggregated evidence indicates a consistent detrimental effect of...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000342
更新日期:2017-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Dental professionals and their physicians frequently do not recognize, accurately diagnose or appropriately manage occupational allergies. Dental allergen identification, diagnostics and practical avoidance strategies are summarized in this review. RECENT FINDINGS:Methacrylates, natural rubber latex ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200410000-00012
更新日期:2004-10-01 00:00:00
abstract::Conventional immunotherapy may be associated with the development of adverse reactions, including anaphylaxis, due to the use of increasing doses of allergen. Standardization of extracts is necessary in order to assess the correct amount of allergen administered. In recent years, increased knowledge on the molecular s...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200112000-00010
更新日期:2001-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Selective immediate reactions to NSAIDs imply that patients develop a urticarial/anaphylactic response to a single drug with good tolerance to other compounds. No systematic review of these reactions has yet been made. RECENT FINDINGS:With the increase in consumption of NSAIDs, these have become one ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32832db943
更新日期:2009-08-01 00:00:00
abstract:PURPOSE OF REVIEW:In this article we consider the characteristics that are associated with chemical respiratory allergens, and that may be essential for effective sensitization of the respiratory tract. RECENT FINDINGS:Chemical respiratory allergens share some characteristics with other chemical allergens, specificall...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000162302.82233.93
更新日期:2005-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Children with asthma require care that is seamlessly coordinated so that asthma symptoms are recognized and managed at home and at school. The purpose of this review is to discuss recent consensus recommendations in school-based asthma care. RECENT FINDINGS:The School-based Asthma Management Program ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000347
更新日期:2017-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews recent findings on the skin microbiome. It provides an update on the current understanding of the role of microbiota in healthy skin and in inflammatory and allergic skin diseases. RECENT FINDINGS:Advances in computing and high-throughput sequencing technology have enabled in-dep...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328364ebeb
更新日期:2013-10-01 00:00:00