Abstract:
PURPOSE OF REVIEW:The purpose of this review is to compare and contrast the newer inhaled corticosteroid (ICS) ciclesonide with older ICSs in terms of pharmacodynamic and pharmacokinetic properties and how these affect comparative efficacy. In addition, clinical dosing strategies for ICSs including as-needed use will be explored. RECENT FINDINGS:Ciclesonide has demonstrated similar efficacy to that of fluticasone propionate and mometasone furoate in equipotent doses with a potentially improved therapeutic index. Once-daily administration of ICSs is generally not as effective as twice-daily. Continuous administration of ICSs does not change the natural history of asthma in either children or adults. Long-term administration of medium dose ICSs does not increase the risk of cataracts or osteopenia in children and young adults. Studies of as-needed ICSs in mild persistent asthma in adults and children have demonstrated mixed results, with some showing equal efficacy to continuous therapy and others showing superiority of continuous therapy. SUMMARY:Ciclesonide provides a newer ICS with favorable pharmacokinetics that may improve the therapeutic index, but assessment of its systemic effects such as growth await further studies. Continuous administration of ICSs in low to medium dose over many years is well tolerated. The use of as-needed ICSs in patients with mild persistent asthma is promising as a potential step-down therapy but awaits further studies.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Stoloff SW,Kelly HWdoi
10.1097/ACI.0b013e328348a813subject
Has Abstractpub_date
2011-08-01 00:00:00pages
337-44issue
4eissn
1528-4050issn
1473-6322pii
00130832-201108000-00012journal_volume
11pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Unverified penicillin allergy is being increasingly recognized as a public health concern. The ideal protocol for verifying true clinically significant IgE-mediated penicillin allergy needs to use only commercially available materials, be well tolerated and easy to perform in both the inpatient and ou...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000173
更新日期:2015-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Evidence suggests that some structural changes caused by mucosal remodeling may be primarily irreversible, which theoretically challenges the current management model of chronic rhinosinusitis (CRS). The relationship between inflammation and remodeling in the mucosa remains complex, yet better underst...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32835ad09e
更新日期:2013-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Drug allergy is an adverse drug reaction that is immune-mediated. Immune activation can occur when drugs or haptens bind covalently to proteins and then act as antigens. The purpose of this review is to summarize the recent data on the formation of hapten-protein complexes and to assess the importance...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000078
更新日期:2014-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Omalizumab has been proposed for controlling adverse reactions during drug desensitization. Our aim is to know the current evidence involving the use of omalizumab in drug-allergy desensitization. RECENT FINDINGS:Drug-allergy desensitization is not risk free, but it is a useful procedure and has been...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000648
更新日期:2020-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The current EAACI/GA²LEN/EDF/WAO treatment guidelines for the management of urticaria recommend omalizumab as fourth-line therapy. Within the last year, many reports of omalizumab treatment in chronic urticaria have been published. RECENT FINDINGS:Two multicenter, randomized, placebo-controlled trial...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e328355365a
更新日期:2012-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Many interventions have been undertaken in managing asthma in a population-based framework. The identification of successful interventions would guide policy implementation to improve outcomes in patient morbidity and mortality and healthcare costs. RECENT FINDINGS:Several studies have focussed on em...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32814a5583
更新日期:2007-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitates a better understanding, accurate diagnosis, and proper management of asthmatic reactions provoked at the workplace. RECENT FINDINGS:Increased recruitment and infiltration of ne...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000507
更新日期:2019-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To present the most recent evidence on beta-lactam hypersensitivity reactions in children. RECENT FINDINGS:Drug provocation tests (DPTs) are the gold standard when investigating beta-lactam allergy in children and evidence is increasingly supporting DPTs without skin tests as a safe approach when eva...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000453
更新日期:2018-08-01 00:00:00
abstract:PURPOSE OF REVIEW:There is considerable evidence that implicates eosinophils as important effector cells in the inflammation characteristic of eosinophilic asthma. IL-5 is central to eosinophil maturation and release from the bone marrow, their subsequent accumulation, activation and persistence in the tissues. IL-5 th...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000183
更新日期:2015-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome is a fatal syndrome of overwhelming autoimmunity. Recent identification of FOXP3 as the causative gene and realization that this same gene defect occurs in the mutant mouse Scurfy has yielded new insights and hopes of unraveling ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200212000-00002
更新日期:2002-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma is the most common, potentially serious medical problem to complicate pregnancy. Women with asthma have been shown to be at increased risk of complications during pregnancy. Managing asthma during pregnancy is unique because the effect of both the illness and the treatment on the developing fet...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000168786.59335.c3
更新日期:2005-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma affects more than 25 million people worldwide and continues to grow in prevalence. According to a center for disease control and prevention (CDC) report, the total annual cost of asthma in the United States between 2008 and 2013, including medical care, absenteeism, and mortality, was $81.9 bil...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000518
更新日期:2019-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Most asthma patients are easily managed with a standard combination of therapies consisting of inhaled controller and reliever drugs, but there remains a large unmet need at the severe end of the disease spectrum. For these patients, development of safer and more effective therapies for asthmatic pati...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000012
更新日期:2013-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Dry eye disease (DED) is a complex, multifactorial condition that is challenging to diagnose and monitor clinically. To date, diagnosis has consisted largely of self-reported symptom questionnaires and a collection of clinical tests including vital dye staining, estimation of tear breakup time and Sch...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000307
更新日期:2016-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to examine in detail the new advances in the pathomechanisms and diagnosis of immediate and nonimmediate hypersensitivity reactions to quinolones, as well as analyze cross-reactivity among different quinolones. RECENT FINDINGS:Hypersensitivity reactions to quinolones, es...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283489bc3
更新日期:2011-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS:The aggregated evidence indicates a consistent detrimental effect of...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000342
更新日期:2017-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Personalized medicine encompasses the use of biological information such as genomics to provide tailored interventions for patients. The review explores the ethical, legal, and social issues that have emerged with personalized medicine and must be considered because of the complex nature of providing ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000091
更新日期:2014-10-01 00:00:00
abstract:PURPOSE OF REVIEW:In the US anterior ocular inflammatory disease (AOID) composed of the spectrum of ocular allergies, different forms of infectious conjunctivitis, and dry eye diseases, affects over 40% of the population. This review evaluates the current economic costs for AOID associated pharmacotherapies. RECENT FI...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000562
更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Allergic conjunctivitis is common and may be the most prominent or the only feature of allergies. Immunotherapy has been used as a primary treatment for allergies since the early 1900s. Currently the use of immunotherapy for allergic rhinoconjunctivitis is well established and has been shown to decrea...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200210000-00013
更新日期:2002-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent investigation has resulted in significant advances toward definitive therapeutic options for food allergy. In this review, we will explore novel immunotherapeutic interventions for the active treatment of food allergy. RECENT FINDINGS:Because the injection route for allergen immunotherapy to f...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32833fd5eb
更新日期:2010-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Asthma features a high degree of heterogeneity in both pathophysiology and therapeutic response, resulting in many asthma patients being treated inadequately. Biomarkers indicative of underlying pathological processes could be used to identify disease subtypes, determine prognosis and to predict or mo...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000426
更新日期:2018-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Increasing understanding of mechanisms and influencing factors in the development of uncontrolled inflammatory responses in atopy and asthma should serve for the introduction of new preventive measures. This review tries to present the current state of the art and resumes that until now, no really eff...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32835eb7b1
更新日期:2013-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Dental professionals and their physicians frequently do not recognize, accurately diagnose or appropriately manage occupational allergies. Dental allergen identification, diagnostics and practical avoidance strategies are summarized in this review. RECENT FINDINGS:Methacrylates, natural rubber latex ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200410000-00012
更新日期:2004-10-01 00:00:00
abstract::Ocular allergy presents unsolved mysteries in molecular and cellular mechanisms, and at the same time continues to challenge ophthalmologists daily in a wide array of disease forms. The recent understanding of the key role of the T helper type 2 cytokines, adhesion molecules and chemokines may provide future avenues f...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000011063.28808.cc
更新日期:2001-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite increased clinician awareness, nonadherence to inhaled corticosteroid treatment presents a major challenge to successful asthma management and risks inappropriate treatment escalation, particularly in severe disease. In patients with Type-2 mediated biology, fractional exhaled nitric oxide (Fe...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000704
更新日期:2021-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Due to the continuously changing environmental conditions, it is necessary to regularly monitor and update the spectrum of contact allergens that elicit contact dermatitis. New contact allergens and known contact allergens with currently increasing importance need to be identified for diagnostic and p...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3282a64241
更新日期:2007-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Biological hypersensitivity to environmental stimuli is a fundamental feature of atopy predisposing to a number of clinically expressed disorders including allergic rhinitis, atopic dermatitis or eczema, and allergic asthma. There is provocative evidence that psychological stress constitutes an increa...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/00130832-200502000-00006
更新日期:2005-02-01 00:00:00
abstract:PURPOSE OF REVIEW:Complementary medicines, including acupuncture and Chinese herbal medicine, are being used increasingly for the management of allergies such as allergic rhinitis. Until relatively recently, however, evidence for the efficacy and safety of these therapies in allergic conditions has been lacking. RECEN...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/01.all.0000225156.29780.36
更新日期:2006-06-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the association between the common dominantly inherited genetic trait hereditary alpha-tryptasemia (HαT) and hymenoptera venom-induced anaphylaxis (HVA). RECENT FINDINGS:Elevated BST has been correlated with more severe systemic anaphylaxis in humans in a number of settings - most notably ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
doi:10.1097/ACI.0000000000000678
更新日期:2020-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the recent advancements in common variable immune deficiency (CVID), specifically CVID genetics, clinical discoveries and treatment implications. RECENT FINDINGS:Large genomic studies have implicated new genes in the pathogenesis of CVID, and basic science studies have contributed to our...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32835914b9
更新日期:2012-12-01 00:00:00