Proteomic applications in food allergy: food allergenomics.

abstract：PURPOSE OF REVIEW:Anaphylactic cardiovascular collapse can be resistant to treatment with epinephrine (adrenaline) and, in some cases, diagnostic uncertainty compromises follow-up care. The purpose of this review is to examine recent studies relevant to the management and diagnosis of this condition. RECENT FINDINGS:N...

journal_title：Current opinion in allergy and clinical immunology

authors： Brown SG

更新日期：2005-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes current knowledge regarding the control of human mast cell and basophil signaling and recent developments using a new therapeutic platform consisting of a human bifunctional gamma and epsilon heavy chain (Fc gamma-Fc epsilon) protein to inhibit allergic reactivity. RECENT FINDI...

journal_title：Current opinion in allergy and clinical immunology

authors： Saxon A,Zhu D,Zhang K,Allen LC,Kepley CL

更新日期：2004-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Innate lymphoid type 2 cells (ILC2) have a critical role in the initiation and regulation of type 2 immune responses and are recognized as an important source of type-2 cytokines. Here, we present recent findings of the role of ILC2 in the integration, processing, and coordination of innate and adapti...

journal_title：Current opinion in allergy and clinical immunology

authors： Vreugde S,Wormald PJ

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the recent insights into the definition, causes, natural outcome, and key elements of irritant-induced asthma (IIA) management. RECENT FINDINGS:IIA is a subtype of occupational asthma without immunologic sensitization and includes the typical reactive airway dysfunction syndrome (RADS) an...

journal_title：Current opinion in allergy and clinical immunology

authors： Labrecque M

更新日期：2012-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Allergen-specific immunotherapy is the only curative treatment for allergic diseases. In spite of the great progress in both vaccine development and the methods of allergen immunotherapy (AIT) in recent years, several key problems related to limited efficacy, side-effects, low patient adherence and th...

journal_title：Current opinion in allergy and clinical immunology

authors： Jutel M,Akdis CA

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review updates current findings on long-term clinical and immunological outcomes after cessation of allergen immunotherapy for allergic respiratory disease. RECENT FINDINGS:Recent studies have shown that allergen immunotherapy has sustained disease-modifying effects that persist for years...

journal_title：Current opinion in allergy and clinical immunology

authors： Eifan AO,Shamji MH,Durham SR

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To analyse the most recently published studies on the prevalence of allergic conjunctivitis alone or in association with allergic rhinitis, and the clinical and demographic aspects of the disease. RECENT FINDINGS:Allergic conjunctivitis or conjunctival symptoms are present in 30-71% of patients with ...

journal_title：Current opinion in allergy and clinical immunology

authors： Leonardi A,Castegnaro A,Valerio AL,Lazzarini D

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Subcutaneous IgG (SCIG) is becoming more popular, but there is still uncertainty about efficacy and optimal dosing. This review discusses recent pharmacokinetic studies and applications of SCIG therapy, and its efficacy in the context of emerging understanding of the relationship between dosing and ef...

journal_title：Current opinion in allergy and clinical immunology

authors： Berger M

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The increase in asthma prevalence over the past 50 years suggests that exposures to environmental risk factors have also increased during this time. Environmental tobacco smoke is one of the most common indoor air pollutants and has been associated in epidemiologic studies with airway and allergic phe...

journal_title：Current opinion in allergy and clinical immunology

authors： Kurz T,Ober C

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the present review is to introduce recent findings on the pathomechanisms of toxic epidermal necrolysis (TEN), which is characterized by widespread epidermal detachment due to keratinocyte apoptosis. RECENT FINDINGS:In the mechanism of epidermal damage, the roles of drug metabolites, c...

journal_title：Current opinion in allergy and clinical immunology

authors： Tohyama M,Hashimoto K

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes the diverse clinical manifestations of IgE-mediated allergy to ingested wheat and summarizes recent advances in characterization of clinically significant allergens and diagnostic workup. RECENT FINDINGS:Recent population-based studies have shown the prevalence of wheat allergy ...

journal_title：Current opinion in allergy and clinical immunology

authors： Inomata N

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:During the past decade, easy access to sequence analyses has allowed us to increase our understanding of the pathogenesis of severe combined immunodeficiencies. Here, we describe the expanding clinical and immunological spectrum associated with Omenn syndrome phenotype. In particular, we review the ce...

journal_title：Current opinion in allergy and clinical immunology

authors： Marrella V,Maina V,Villa A

更新日期：2011-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite asthma being widely regarded as a heterogeneous disease, a consensus for an accurate system of classification has not been agreed. Recent studies have suggested that the recognition of subphenotypes of asthma based on the pattern of airway inflammation may be particularly useful in increasing ...

journal_title：Current opinion in allergy and clinical immunology

authors： Green RH,Brightling CE,Bradding P

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Biological hypersensitivity to environmental stimuli is a fundamental feature of atopy predisposing to a number of clinically expressed disorders including allergic rhinitis, atopic dermatitis or eczema, and allergic asthma. There is provocative evidence that psychological stress constitutes an increa...

journal_title：Current opinion in allergy and clinical immunology

authors： Wright RJ,Cohen RT,Cohen S

更新日期：2005-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Modern food animal production is a major contributor to the global economy, owing to advanced intensive indoor production facilities aimed at increasing market readiness and profit. Consequences of these advances are accumulation of dusts, gases, and microbial products that diminish air quality within...

journal_title：Current opinion in allergy and clinical immunology

authors： McClendon CJ,Gerald CL,Waterman JT

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we herein describe the progress in management of severe asthma, evolving from a 'blockbuster approach' to a more personalized approach targeted to the utilization of endotype-driven therapies. RECENT FINDINGS:Severe asthma characterization in phenotypes and endotypes, by means of spec...

journal_title：Current opinion in allergy and clinical immunology

authors： Canonica GW,Ferrando M,Baiardini I,Puggioni F,Racca F,Passalacqua G,Heffler E

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:An exposition of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to recommendations. RECENT FINDINGS:In this review, we outline the process whereby the strength of evidence from the literature undergoes a systematic reappraisal. The GRADE system allows four grad...

journal_title：Current opinion in allergy and clinical immunology

authors： Terracciano L,Brozek J,Compalati E,Schünemann H

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Allergen immunotherapy (AIT) is still the only causal treatment for allergic rhinitis and asthma. However, conventional subcutaneous AIT administration schedules are time-consuming and safety issues still play a role; for sublingual AIT, the best efficacy is still investigated and for food allergy the...

journal_title：Current opinion in allergy and clinical immunology

authors： Larenas-Linnemann D

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Knowledge of the epidemiology, natural history and risk factors of insect-venom allergy is crucial for improving the clinical management of allergic patients. This review focuses on the recent research on these aspects of Hymenoptera-sting anaphylactic reactions. RECENT FINDINGS:The latest data from ...

journal_title：Current opinion in allergy and clinical immunology

authors： Bilò BM,Bonifazi F

更新日期：2008-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To present and discuss key design concepts for optimizing the impact of observational studies in the field of allergy and to highlight recent findings from NIAID-funded research networks. RECENT FINDINGS:We discuss three concepts. First, the benefit of prospective, longitudinal observational studies ...

journal_title：Current opinion in allergy and clinical immunology

authors： Rudman Spergel AK,Togias A

更新日期：2020-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Children with asthma require care that is seamlessly coordinated so that asthma symptoms are recognized and managed at home and at school. The purpose of this review is to discuss recent consensus recommendations in school-based asthma care. RECENT FINDINGS:The School-based Asthma Management Program ...

journal_title：Current opinion in allergy and clinical immunology

authors： Kakumanu S,Antos N,Szefler SJ,Lemanske RF Jr

更新日期：2017-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Dry eye disease (DED) is a complex, multifactorial condition that is challenging to diagnose and monitor clinically. To date, diagnosis has consisted largely of self-reported symptom questionnaires and a collection of clinical tests including vital dye staining, estimation of tear breakup time and Sch...

journal_title：Current opinion in allergy and clinical immunology

authors： Dohlman TH,Ciralsky JB,Lai EC

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitates a better understanding, accurate diagnosis, and proper management of asthmatic reactions provoked at the workplace. RECENT FINDINGS:Increased recruitment and infiltration of ne...

journal_title：Current opinion in allergy and clinical immunology

authors： Choi Y,Lee Y,Park HS

更新日期：2019-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent investigation has resulted in significant advances toward definitive therapeutic options for food allergy. In this review, we will explore novel immunotherapeutic interventions for the active treatment of food allergy. RECENT FINDINGS:Because the injection route for allergen immunotherapy to f...

journal_title：Current opinion in allergy and clinical immunology

authors： Scurlock AM,Jones SM

更新日期：2010-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Mastocytosis is a rare disease characterized by increased mast cells in skin and/or internal organs. We evaluate the impact of mastocytosis on diagnosis and treatment of Hymenoptera venom allergy. RECENT FINDINGS:Patients with Hymenoptera venom allergy who suffer from mastocytosis develop life-threat...

journal_title：Current opinion in allergy and clinical immunology

authors： Ruëff F,Placzek M,Przybilla B

更新日期：2006-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In adults with eosinophilic esophagitis (EoE), a chronic, inflammatory immune-mediated condition of the esophagus, both inflammation and fibrosis are likely associated with symptom generation. Therefore, assessing symptom-based patient-reported outcomes (PROs), defined by US Food and Drug Administrati...

journal_title：Current opinion in allergy and clinical immunology

authors： Safroneeva E,Schoepfer AM

更新日期：2019-04-01 00:00:00

abstract：:Allergic diseases such as atopic dermatitis, rhinitis and asthma are thought to result from a dysregulated immune response to commonly encountered antigens in genetically predisposed individuals. This response leads to chronic eosinophil-rich allergic inflammation and is controlled by Th2 lymphocytes. The first step i...

journal_title：Current opinion in allergy and clinical immunology

authors： Lambrecht BN

更新日期：2001-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Contact lens-induced papillary conjunctivitis (CLPC) is a common ocular allergic disease in contact lens wearers. In its more severe form, it can cause giant papillary conjunctivitis, resulting in contact lens intolerance and the need to discontinue the use of contact lenses. This review presents the ...

journal_title：Current opinion in allergy and clinical immunology

authors： Solomon A

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the strengths and challenges of using whole genome sequencing (WGS)/whole exome sequencing (WES) for identifying novel genetic causes of primary immunodeficiencies. RECENT FINDINGS:WGS permits comprehensive sequencing of introns and exons, whereas WES allows deeper sequencing of...

journal_title：Current opinion in allergy and clinical immunology

authors： Chou J,Ohsumi TK,Geha RS

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Anaphylaxis due to ant sting is increasingly being recognized as a significant problem. Severe allergic reactions to ants are well described in the south-eastern United States, but have only been recognized in recent years as being important in other parts of the world. There are many different ant sp...

journal_title：Current opinion in allergy and clinical immunology

authors： Shek LP,Ngiam NS,Lee BW

更新日期：2004-08-01 00:00:00