Abstract:
PURPOSE OF REVIEW:Allergen-specific immunotherapy is the only curative treatment for allergic diseases. In spite of the great progress in both vaccine development and the methods of allergen immunotherapy (AIT) in recent years, several key problems related to limited efficacy, side-effects, low patient adherence and the relatively high costs due to the long duration (3-5 years) remain to be solved. The current approaches aiming at optimization of AIT are reviewed, including both conceptual studies in experimental models and proof-of-concept - as well as large, multicenter clinical studies. RECENT FINDINGS:The most promising approaches to improve efficacy and safety of vaccine-based AIT include bypassing IgE binding and targeting allergen-specific T cells using hypoallergenic recombinant allergen derivatives and immunogenic peptides, the use of new adjuvants and stimulators of the innate immune response, the fusion of allergens to immune modifiers and peptide carrier proteins and new routes of vaccine administration. SUMMARY:The cloning of allergen proteins and genetic engineering enabled the production of vaccines that have well defined molecular, immunologic and biologic characteristics as well as modified molecular structure. These new compounds along with new immunization protocols can bring us closer to the ultimate goal of AIT, that is, complete cure of a large number of allergic patients.
journal_name
Curr Opin Allergy Clin Immunoljournal_title
Current opinion in allergy and clinical immunologyauthors
Jutel M,Akdis CAdoi
10.1097/ACI.0000000000000121subject
Has Abstractpub_date
2014-12-01 00:00:00pages
557-63issue
6eissn
1528-4050issn
1473-6322journal_volume
14pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Allergic rhinitis due its high prevalence and burden needs to be properly treated. The disease's clinical features impose well tolerated drugs usable for long-term treatment. Nowadays, second-generation antihistamines and inhaled steroids represent the milestone of rhinitis therapy. The aim of the pre...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000043
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journal_title:Current opinion in allergy and clinical immunology
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abstract:PURPOSE OF REVIEW:The incidence of food allergy is increasing. Correct diagnosis is dependent on food challenges, which are not always performed, but more often based on history, skin prick test and specific IgE, leading to possible misdiagnoses. Mucosal provocation tests have been proposed as possible new diagnostic t...
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2016-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3283387fae
更新日期:2010-06-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2009-08-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000204
更新日期:2015-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000220
更新日期:2015-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Contact lens-induced papillary conjunctivitis (CLPC) is a common ocular allergic disease in contact lens wearers. In its more severe form, it can cause giant papillary conjunctivitis, resulting in contact lens intolerance and the need to discontinue the use of contact lenses. This review presents the ...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000137
更新日期:2015-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0000000000000572
更新日期:2019-10-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight recent advances in gene-expression profiling of nasal polyps in patients with chronic rhinosinusitis and aspirin-sensitive asthma. RECENT FINDINGS:Gene-expression profiling has allowed simultaneous interrogation of thousands of genes, including the entire ge...
journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32831d8170
更新日期:2009-02-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e32835eb7b1
更新日期:2013-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
doi:10.1097/ACI.0b013e3282a64241
更新日期:2007-10-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,收录出版
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更新日期:2020-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2018-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
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更新日期:2008-12-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
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journal_title:Current opinion in allergy and clinical immunology
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00