Sublingual immunotherapy: update 2006.

abstract：PURPOSE OF REVIEW:Asthma is the most common, potentially serious medical problem to complicate pregnancy. Women with asthma have been shown to be at increased risk of complications during pregnancy. Managing asthma during pregnancy is unique because the effect of both the illness and the treatment on the developing fet...

journal_title：Current opinion in allergy and clinical immunology

authors： Namazy JA,Schatz M

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Component-resolved diagnosis (CRD) is an advanced tool capable of aiding the clinician in fine tuning the diagnosis of the causal allergens of a reaction with the added value of providing information of severity risk, potential cross-reactivity, and subsequently, guiding management measures. This revi...

journal_title：Current opinion in allergy and clinical immunology

authors： Cardona V,Ansotegui IJ

更新日期：2016-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Allergen immunotherapy (AIT) is still the only causal treatment for allergic rhinitis and asthma. However, conventional subcutaneous AIT administration schedules are time-consuming and safety issues still play a role; for sublingual AIT, the best efficacy is still investigated and for food allergy the...

journal_title：Current opinion in allergy and clinical immunology

authors： Larenas-Linnemann D

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin D deficiency has been rediscovered as a public-health problem worldwide. It has been postulated that vitamin D deficiency may explain a portion of the asthma epidemic. The purpose of this review is to present the evidence for a role of vitamin D in asthma. RECENT FINDINGS:Both animal models a...

journal_title：Current opinion in allergy and clinical immunology

authors： Litonjua AA

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The increase in asthma prevalence over the past 50 years suggests that exposures to environmental risk factors have also increased during this time. Environmental tobacco smoke is one of the most common indoor air pollutants and has been associated in epidemiologic studies with airway and allergic phe...

journal_title：Current opinion in allergy and clinical immunology

authors： Kurz T,Ober C

更新日期：2004-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We provide an overview on the latest developments in primary immunodeficiency registries worldwide, on the basis of the recent literature amended by some older references to achieve completeness. RECENT FINDINGS:New primary immunodeficiency registries are emerging worldwide, although existing databas...

journal_title：Current opinion in allergy and clinical immunology

authors： Kindle G,Gathmann B,Grimbacher B

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Unverified penicillin allergy is being increasingly recognized as a public health concern. The ideal protocol for verifying true clinically significant IgE-mediated penicillin allergy needs to use only commercially available materials, be well tolerated and easy to perform in both the inpatient and ou...

journal_title：Current opinion in allergy and clinical immunology

authors： Macy E

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the data of both preclinical studies and initial clinical trials of a novel allergoid for allergen specific immunotherapy. This allergoid consists of allergen covalently coupled to immunostimulatory oligodeoxynucleotide DNA sequences. RECENT FINDINGS:Recently, immunostimulatory oligodeox...

journal_title：Current opinion in allergy and clinical immunology

authors： Spiegelberg HL,Horner AA,Takabayashi K,Raz E

更新日期：2002-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the present review is to introduce recent findings on the pathomechanisms of toxic epidermal necrolysis (TEN), which is characterized by widespread epidermal detachment due to keratinocyte apoptosis. RECENT FINDINGS:In the mechanism of epidermal damage, the roles of drug metabolites, c...

journal_title：Current opinion in allergy and clinical immunology

authors： Tohyama M,Hashimoto K

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Dendritic cells are essential for the generation of innate and adaptive immune responses, which makes them stay on center stage when studying the immuno pathogenesis of atopic dermatitis. This review will discuss recent findings on the role of dendritic cells subsets in atopic dermatitis and will repo...

journal_title：Current opinion in allergy and clinical immunology

authors： Schäkel K,Hänsel A

更新日期：2011-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy has emerged as a significant health problem. Peanut allergy is a major cause of food-induced fatal and near fatal anaphylactic reactions, and the incidence in children is increasing. Attempts to manage peanut allergy by strict avoidance are often unsuccessful. The purpose of this review i...

journal_title：Current opinion in allergy and clinical immunology

authors： Li XM

更新日期：2005-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Personalized medicine encompasses the use of biological information such as genomics to provide tailored interventions for patients. The review explores the ethical, legal, and social issues that have emerged with personalized medicine and must be considered because of the complex nature of providing ...

journal_title：Current opinion in allergy and clinical immunology

authors： Joly Y,Saulnier KM,Osien G,Knoppers BM

更新日期：2014-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Knowledge of the epidemiology, natural history and risk factors of insect-venom allergy is crucial for improving the clinical management of allergic patients. This review focuses on the recent research on these aspects of Hymenoptera-sting anaphylactic reactions. RECENT FINDINGS:The latest data from ...

journal_title：Current opinion in allergy and clinical immunology

authors： Bilò BM,Bonifazi F

更新日期：2008-08-01 00:00:00

abstract：:Asthma is a disease that is, in large part, defined by abnormalities of pulmonary function. Failure of any new treatment modality to improve objective measures of lung function suggests a limited usefulness of such new therapies. The clear dissociation between inflammation and airways responsiveness indicates the latt...

journal_title：Current opinion in allergy and clinical immunology

authors： Kaminsky DA,Irvin CG

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews recent findings on the skin microbiome. It provides an update on the current understanding of the role of microbiota in healthy skin and in inflammatory and allergic skin diseases. RECENT FINDINGS:Advances in computing and high-throughput sequencing technology have enabled in-dep...

journal_title：Current opinion in allergy and clinical immunology

authors： Zeeuwen PL,Kleerebezem M,Timmerman HM,Schalkwijk J

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the results from recent studies that assessed the burden of allergic diseases on the patients' every-day life, or contributed to new advances in monitoring quality-of-life in allergic disorders. This review will not report the numerous clinical trials that included quality-of-life as an outc...

journal_title：Current opinion in allergy and clinical immunology

authors： Leynaert B,Soussan D

更新日期：2003-06-01 00:00:00

abstract：:Ants belong to the order Hymenoptera, along with bees, wasps, yellow jackets, etc., they are the most successful animal genera in this world. It is their selfless social structure which accounts for their huge impact. Their effect on man ranges from the parasol ant, which makes plant cultivation untenable in certain p...

journal_title：Current opinion in allergy and clinical immunology

authors： Rhoades R

更新日期：2001-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Drug allergy is an adverse drug reaction that is immune-mediated. Immune activation can occur when drugs or haptens bind covalently to proteins and then act as antigens. The purpose of this review is to summarize the recent data on the formation of hapten-protein complexes and to assess the importance...

journal_title：Current opinion in allergy and clinical immunology

authors： Faulkner L,Meng X,Park BK,Naisbitt DJ

更新日期：2014-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will cover advances over the past year in defining airway endotypes in asthma by gene expression and the relationship between these endotypes and clinical traits. RECENT FINDINGS:Expression profiling studies of asthmatic airway samples continue to reveal significant heterogeneity in airwa...

journal_title：Current opinion in allergy and clinical immunology

authors： Wesolowska-Andersen A,Seibold MA

更新日期：2015-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent developments on the inter-relationship between food allergy and atopic eczema, with a particular focus on understanding the role of filaggrin gene defects. RECENT FINDINGS:Filaggrin gene defects have recently been identified as a major risk factor for the development of atopic eczema...

journal_title：Current opinion in allergy and clinical immunology

authors： Worth A,Sheikh A

更新日期：2010-06-01 00:00:00

abstract：:The role of indoor allergen exposure in the development of sensitization and asthma remains a subject of controversy. From a number of cross-sectional and longitudinal studies we can conclude that there is a very close association between allergen exposure and the sensitization of an individual. The dose-response rela...

journal_title：Current opinion in allergy and clinical immunology

authors： Murray CS,Woodcock A,Custovic A

更新日期：2001-10-01 00:00:00

abstract：:It is clear that airway smooth muscle plays an important role in the hyperresponsiveness and remodelling that occur in the asthmatic airway. This is by virtue of its roles as a contractile cell, a cell that undergoes proliferation as part of the inflammatory response, a cell that actively participates in the inflammat...

journal_title：Current opinion in allergy and clinical immunology

authors： Black JL,Johnson PR

更新日期：2002-02-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we summarize the latest publications on the genetic and environmental determinants of allergic rhinitis. RECENT FINDINGS:Recent advances in genetic technology and bioinformatics have enabled simultaneous unbiased analysis of the entire genome regarding DNA sequence variants, epigeneti...

journal_title：Current opinion in allergy and clinical immunology

authors： Chiarella SE,Fernandez R,Avila PC

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Cow's milk allergy affects 2-3% of young children, the economic impact of which necessitates search for simple diagnostic tools and affordable milk substitutes. This review examines recent studies on the diagnosis of cow's milk allergy as well as on the allergenicity of milk from other mammalian speci...

journal_title：Current opinion in allergy and clinical immunology

authors： Järvinen KM,Chatchatee P

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Atopic dermatitis is typified by itchy, inflamed skin. It is increasingly common in the developed world and is a major cause of morbidity in infants and young children. Most children with the disease have high levels of immunoglobulin E and many have concomitant asthma. The cause of the disease is unk...

journal_title：Current opinion in allergy and clinical immunology

authors： Cookson WO,Moffatt MF

更新日期：2002-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To present the most recent evidence on beta-lactam hypersensitivity reactions in children. RECENT FINDINGS:Drug provocation tests (DPTs) are the gold standard when investigating beta-lactam allergy in children and evidence is increasingly supporting DPTs without skin tests as a safe approach when eva...

journal_title：Current opinion in allergy and clinical immunology

authors： Graham F,Tsabouri S,Caubet JC

更新日期：2018-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Gene therapy for severe combined immunodeficiency due to adenosine deaminase deficiency has moved from the early trials of safety and feasibility to recent studies demonstrating efficacy and clinical benefit. This review describes the latest advances in gene therapy trials for this condition using per...

journal_title：Current opinion in allergy and clinical immunology

authors： Aiuti A,Ficara F,Cattaneo F,Bordignon C,Roncarolo MG

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:An exposition of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to recommendations. RECENT FINDINGS:In this review, we outline the process whereby the strength of evidence from the literature undergoes a systematic reappraisal. The GRADE system allows four grad...

journal_title：Current opinion in allergy and clinical immunology

authors： Terracciano L,Brozek J,Compalati E,Schünemann H

更新日期：2010-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing understanding of mechanisms and influencing factors in the development of uncontrolled inflammatory responses in atopy and asthma should serve for the introduction of new preventive measures. This review tries to present the current state of the art and resumes that until now, no really eff...

journal_title：Current opinion in allergy and clinical immunology

authors： Lau S

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To analyze recent findings on antibiotic hypersensitivity reactions in children focusing on betalactams, with regard to clinical entities, antibiotics involved and diagnostic methods. RECENT FINDINGS:Betalactams are the most frequent cause of antibiotic hypersensitivity, more specifically amoxicillin...

journal_title：Current opinion in allergy and clinical immunology

authors： Fernandez TD,Mayorga C,Ariza A,Corzo JL,Torres MJ

更新日期：2014-08-01 00:00:00