Intravenous immunoglobulins in the treatment of severe drug eruptions.

abstract：PURPOSE OF REVIEW:The purpose of this review is to describe the impact of asthma treatment non-adherence on patients and the healthcare system, and to outline areas of responsibility towards improved adherence. RECENT FINDINGS:The average cost of healthcare expenses for each person in the United States in 2002 was 544...

journal_title：Current opinion in allergy and clinical immunology

authors： Bender BG,Rand C

更新日期：2004-06-01 00:00:00

abstract：:The role of indoor allergen exposure in the development of sensitization and asthma remains a subject of controversy. From a number of cross-sectional and longitudinal studies we can conclude that there is a very close association between allergen exposure and the sensitization of an individual. The dose-response rela...

journal_title：Current opinion in allergy and clinical immunology

authors： Murray CS,Woodcock A,Custovic A

更新日期：2001-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Gene therapy for severe combined immunodeficiency due to adenosine deaminase deficiency has moved from the early trials of safety and feasibility to recent studies demonstrating efficacy and clinical benefit. This review describes the latest advances in gene therapy trials for this condition using per...

journal_title：Current opinion in allergy and clinical immunology

authors： Aiuti A,Ficara F,Cattaneo F,Bordignon C,Roncarolo MG

更新日期：2003-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the strengths and challenges of using whole genome sequencing (WGS)/whole exome sequencing (WES) for identifying novel genetic causes of primary immunodeficiencies. RECENT FINDINGS:WGS permits comprehensive sequencing of introns and exons, whereas WES allows deeper sequencing of...

journal_title：Current opinion in allergy and clinical immunology

authors： Chou J,Ohsumi TK,Geha RS

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the theoretical background and current evidence regarding parent-initiated oral corticosteroid (PIOCS) therapy in preschool wheeze and asthma in school-aged children. RECENT FINDINGS:In school-aged children with asthma PIOCS, given during acute episodes, has been associated with a modest re...

journal_title：Current opinion in allergy and clinical immunology

authors： Vuillermin PJ,Robertson CF,South M

更新日期：2011-06-01 00:00:00

abstract：PURPOSE OF REVIEW:An inverse relationship between resistance to certain parasitic diseases and measures of atopy and asthma has long been observed. A possible explanation is that genetic determinants which confer protection against detrimental worm burdens are the same determinants involved in atopic asthma. The focus ...

journal_title：Current opinion in allergy and clinical immunology

authors： Barnes KC,Grant AV,Gao P

更新日期：2005-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Innate lymphoid type 2 cells (ILC2) have a critical role in the initiation and regulation of type 2 immune responses and are recognized as an important source of type-2 cytokines. Here, we present recent findings of the role of ILC2 in the integration, processing, and coordination of innate and adapti...

journal_title：Current opinion in allergy and clinical immunology

authors： Vreugde S,Wormald PJ

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to recap recent published data on immunological mechanisms underlying sublingual immunotherapy (SLIT). RECENT FINDINGS:Although several alternative noninvasive allergen application strategies have been investigated in allergen-specific immunotherapy, local intraoral allergen applicat...

journal_title：Current opinion in allergy and clinical immunology

authors： Allam JP,Novak N

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The current EAACI/GA²LEN/EDF/WAO treatment guidelines for the management of urticaria recommend omalizumab as fourth-line therapy. Within the last year, many reports of omalizumab treatment in chronic urticaria have been published. RECENT FINDINGS:Two multicenter, randomized, placebo-controlled trial...

journal_title：Current opinion in allergy and clinical immunology

authors： Metz M,Maurer M

更新日期：2012-08-01 00:00:00

abstract：:This review summarizes recent advances and findings in the area of 'hidden' food allergens, i.e. allergenic foods that can either contaminate other foods, or be 'disguised' as part of a food, and cause allergic reactions. Newly emerging allergenic foods of increasing importance, recently developed methods for the dete...

journal_title：Current opinion in allergy and clinical immunology

authors： Hefle SL

更新日期：2001-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Biological hypersensitivity to environmental stimuli is a fundamental feature of atopy predisposing to a number of clinically expressed disorders including allergic rhinitis, atopic dermatitis or eczema, and allergic asthma. There is provocative evidence that psychological stress constitutes an increa...

journal_title：Current opinion in allergy and clinical immunology

authors： Wright RJ,Cohen RT,Cohen S

更新日期：2005-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Allergic rhinitis due its high prevalence and burden needs to be properly treated. The disease's clinical features impose well tolerated drugs usable for long-term treatment. Nowadays, second-generation antihistamines and inhaled steroids represent the milestone of rhinitis therapy. The aim of the pre...

journal_title：Current opinion in allergy and clinical immunology

authors： Braido F,Arcadipane F,Marugo F,Hayashi M,Pawankar R

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The review critically assesses the different phenotypes of angioedemas associated with NSAIDs. Angioedemas exacerbated or induced by NSAIDs have high morbidity and, when they affect the larynx, can lead to death by asphyxiation. RECENT FINDINGS:Angioedema can present as a manifestation of a syndrome ...

journal_title：Current opinion in allergy and clinical immunology

authors： Giavina-Bianchi P,Aun MV,Jares EJ,Kalil J

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In the US anterior ocular inflammatory disease (AOID) composed of the spectrum of ocular allergies, different forms of infectious conjunctivitis, and dry eye diseases, affects over 40% of the population. This review evaluates the current economic costs for AOID associated pharmacotherapies. RECENT FI...

journal_title：Current opinion in allergy and clinical immunology

authors： Khan RS,Rizvi S,Syed BA,Bielory L

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Although today's cornerstone therapies for asthma (inhaled bronchodilators and corticosteroids) target airway narrowing and lung inflammation, about half of treated asthmatic patients do not achieve good disease control. There is a clear need for new therapeutic approaches and novel drug targets. Rece...

journal_title：Current opinion in allergy and clinical immunology

authors： Grassin-Delyle S,Naline E,Devillier P

更新日期：2015-02-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent advancements in common variable immune deficiency (CVID), specifically CVID genetics, clinical discoveries and treatment implications. RECENT FINDINGS:Large genomic studies have implicated new genes in the pathogenesis of CVID, and basic science studies have contributed to our...

journal_title：Current opinion in allergy and clinical immunology

authors： Resnick ES,Cunningham-Rundles C

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this article is to review recent primary research and developments in the area of probiotics and pediatric atopic disease. RECENT FINDINGS:Research developments in probiotics summarized in this article include the following: (1) the role of probiotics in primary prevention of atopic disea...

journal_title：Current opinion in allergy and clinical immunology

authors： Ogden NS,Bielory L

更新日期：2005-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Cow's milk allergy affects 2-3% of young children, the economic impact of which necessitates search for simple diagnostic tools and affordable milk substitutes. This review examines recent studies on the diagnosis of cow's milk allergy as well as on the allergenicity of milk from other mammalian speci...

journal_title：Current opinion in allergy and clinical immunology

authors： Järvinen KM,Chatchatee P

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To present an update on the recent advances in the understanding of the mechanisms and practical management of oral mite anaphylaxis (OMA, pancake syndrome). RECENT FINDINGS:Among novel observations regarding OMA, this review highlights the increased prevalence of aspirin/NSAID hypersensitivity inpat...

journal_title：Current opinion in allergy and clinical immunology

authors： Sánchez-Borges M,Capriles-Hulett A,Fernandez-Caldas E

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Targeting allergens to surface receptors on antigen presenting cells may provide a therapeutic strategy for allergic disease. This article discusses the immunomodulatory capacity of a molecule (H22-Fel d 1), which targets the major cat allergen, Fel d 1, to the high affinity IgG receptor, Fc gammaRI, ...

journal_title：Current opinion in allergy and clinical immunology

authors： Hulse KE,Woodfolk JA

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To recognize the relevance of serum tryptase measurement as a useful tool for the diagnosis of allergic diseases and mast cell disorders. RECENT FINDINGS:Recent data on the role of mast cells and tryptase in allergic and other diseases provide new understanding into the mechanisms and causes of anaph...

journal_title：Current opinion in allergy and clinical immunology

authors： Bonadonna P,Scaffidi L,Boni E

更新日期：2019-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the present review is to describe recent approaches aimed at improving the treatment of allergic diseases through allergen-specific immunotherapy (SIT). Special emphasis will be given to the approach based on specific targeting of the major histocompatibility complex (MHC) class-II anti...

journal_title：Current opinion in allergy and clinical immunology

authors： Crameri R,Kündig TM,Akdis CA

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Sublingual immunotherapy is currently accepted as a viable therapeutic option, and is widely used in many European countries. In the past 2 years, new data concerning clinical, immunological and practical aspects of sublingual immunotherapy have been published, and many critical points have been addre...

journal_title：Current opinion in allergy and clinical immunology

authors： Passalacqua G,Canonica GW

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Allergic diseases have only recently gained serious attention in Africa. This review discusses recent studies that have focused on allergy among Africans and people of African ancestry. RECENT FINDINGS:Time trend studies of the prevalence of allergies in Africa show a consistent increase over a perio...

journal_title：Current opinion in allergy and clinical immunology

authors： Obeng BB,Hartgers F,Boakye D,Yazdanbakhsh M

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Most asthma patients are easily managed with a standard combination of therapies consisting of inhaled controller and reliever drugs, but there remains a large unmet need at the severe end of the disease spectrum. For these patients, development of safer and more effective therapies for asthmatic pati...

journal_title：Current opinion in allergy and clinical immunology

authors： Caruso M,Crisafulli E,Lizzio R,Polosa R

更新日期：2013-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to describe the role of precision medicine in the diagnosis, treatment, and monitoring of cow's milk allergy. RECENT FINDINGS:The development of 'omics' sciences in the field of food allergy has led to a better understanding of the allergenicity of cow's milk proteins and si...

journal_title：Current opinion in allergy and clinical immunology

authors： D'Auria E,Venter C

更新日期：2020-06-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we herein describe the progress in management of severe asthma, evolving from a 'blockbuster approach' to a more personalized approach targeted to the utilization of endotype-driven therapies. RECENT FINDINGS:Severe asthma characterization in phenotypes and endotypes, by means of spec...

journal_title：Current opinion in allergy and clinical immunology

authors： Canonica GW,Ferrando M,Baiardini I,Puggioni F,Racca F,Passalacqua G,Heffler E

更新日期：2018-02-01 00:00:00

abstract：PURPOSE OF REVIEW:We provide an overview on the latest developments in primary immunodeficiency registries worldwide, on the basis of the recent literature amended by some older references to achieve completeness. RECENT FINDINGS:New primary immunodeficiency registries are emerging worldwide, although existing databas...

journal_title：Current opinion in allergy and clinical immunology

authors： Kindle G,Gathmann B,Grimbacher B

更新日期：2014-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes current knowledge regarding the control of human mast cell and basophil signaling and recent developments using a new therapeutic platform consisting of a human bifunctional gamma and epsilon heavy chain (Fc gamma-Fc epsilon) protein to inhibit allergic reactivity. RECENT FINDI...

journal_title：Current opinion in allergy and clinical immunology

authors： Saxon A,Zhu D,Zhang K,Allen LC,Kepley CL

更新日期：2004-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews recent findings on the skin microbiome. It provides an update on the current understanding of the role of microbiota in healthy skin and in inflammatory and allergic skin diseases. RECENT FINDINGS:Advances in computing and high-throughput sequencing technology have enabled in-dep...

journal_title：Current opinion in allergy and clinical immunology

authors： Zeeuwen PL,Kleerebezem M,Timmerman HM,Schalkwijk J

更新日期：2013-10-01 00:00:00