Recent advances in understanding the neural bases of autism spectrum disorder.

Abstract:

PURPOSE OF REVIEW:This article reviews current work investigating the neural bases of autism spectrum disorder (ASD) within the discipline of electrophysiological brain research. The manuscript focuses primarily on advances in understanding related to social information processing and interconnectivity among brain systems in ASD. RECENT FINDINGS:Recent research indicates anomalous function of social brain regions in ASD and highlights the specificity of processing problems to these systems. Atypical activity in this circuitry may reflect genetic susceptibility for ASD, with increased activity in compensatory areas marking the distinction between developing and not developing the disorder. Advances in understanding connectivity in ASD are highlighted by novel work providing initial evidence of atypical interconnectivity in infancy. SUMMARY:Emerging understanding of neural dysfunction in ASD indicates consistent but heterogeneous dysfunction across brain systems in ASD. Key objectives for the immediate future include the use of multimethod approaches that encompass temporal and spatial imaging; behavioral phenotyping carried out in developmental context to reveal subgroups defined uniquely by trajectories; and individual-specific profiles of behavioral performance and brain function.

journal_name

Curr Opin Pediatr

authors

McPartland JC,Coffman M,Pelphrey KA

doi

10.1097/MOP.0b013e32834cb9c9

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

628-32

issue

6

eissn

1040-8703

issn

1531-698X

journal_volume

23

pub_type

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